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Design, Synthesis and biochemical evaluation of novel anthracenes, ethanoanthracenes and related compounds to target Burkitt's Lymphoma |
Byrne, Andrew J.
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THESIS 11064 Burkitt's lymphoma is an aggressive non-Hodgkin lymphoma occurring with high
incidence in developing areas such as equatorial Africa and Papua New Guinea. Within these
tropical regions of high incidence (40-50 per 10 6), Burkitt's lymphoma accounts for
approximately 50% of childhood cancers and up to 90% of childhood lymphomas diagnosed.
The treatment of Burkitt's lymphoma in these regions is insufficient and the development of
new, safe and cost effective therapeutics are of current interest. Previous work within the
Meegan and Williams groups in Trinity College Dublin identified a potent apoptotic effect
induced by the (E)-1,3-bis(aryl)-2-nitro-1-propenes and the tetracyclic antidepressant
maprotiline in Burkitt's lymphoma cell lines (MUTU-I and DG-75).
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Keyword(s):
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Pharmacy and Pharmaceutical Sciences, Ph.D.; Ph.D. Trinity College Dublin. |
Publication Date:
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2015 |
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Type:
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Doctoral thesis |
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Peer-Reviewed:
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Unknown |
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Language(s):
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English |
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Institution:
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Trinity College Dublin |
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Citation(s):
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Andrew J. Byrne, 'Design, Synthesis and biochemical evaluation of novel anthracenes, ethanoanthracenes and related compounds to target Burkitt's Lymphoma', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015, pp 466 |
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Publisher(s):
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Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences |
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Supervisor(s):
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Meegan, Mary |
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First Indexed:
2019-10-19 06:58:16 Last Updated:
2019-10-19 06:58:16 |
