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Composite scaffold development and bioreactor culture for bone tissue engineering
Plunkett, Niamh
THESIS 9254 Bone tissue engineering involves seeding bone cells onto a scaffold, culturing this construct so that mineralisation occurs (by using signalling mechanisms such as growth factors or bioreactors) and then implanting it into a defect site in the body. This is called the tissue engineering triad: combining cells, scaffold and signalling to engineer tissue in vitro. In this work, the focus was on two aspects of the triad: scaffold development and signalling using a bioreactor. The general aim in this work was to develop a tissue engineered construct with enhanced osteogenic capabilities due to its structural and material properties, populated by a homogeneous distribution of stimulated cells.
Keyword(s): Mechanical and Manufacturing Engineering, Ph.D.; Ph.D. Trinity College Dublin.
Publication Date:
2009
Type: Doctoral thesis
Peer-Reviewed: Unknown
Language(s): English
Institution: Trinity College Dublin
Citation(s): Niamh Plunkett, 'Composite scaffold development and bioreactor culture for bone tissue engineering', [thesis], Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009, pp 262
Publisher(s): Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering
Supervisor(s): O'Brien, Fergal J.
First Indexed: 2019-11-16 06:58:27 Last Updated: 2019-11-16 06:58:27