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The development of a new class of C-5' substituted cinchona alkaloid derivatives as efficient organocatalysts
Palacio, Carole
THESIS 10151 Over the past three decades, the synthesis of enantiomerically pure products became a major concern in modem research. In this context, organocatalysis has emerged as a viable method and interest in this field has intensified rapidly. In particular, cinchona alkaloids - incorporating two functionalities capable of the synergestic activation of two components of a reaction in a close and chiral environment - appeared as a valuable material in new organocatalysts design. Various cinchona alkaloid derivatives have been demonstrated to be capable of the bifunctional catalysis of a number of asymmetric reactions involving the addition of an acidic pronucleophile to an electrophile incorporating hydrogen-bond accepting functionality.
Keyword(s): Chemistry, Ph.D.; Ph.D. Trinity College Dublin.
Publication Date:
2013
Type: Doctoral thesis
Peer-Reviewed: Unknown
Language(s): English
Institution: Trinity College Dublin
Citation(s): Carole Palacio, 'The development of a new class of C-5' substituted cinchona alkaloid derivatives as efficient organocatalysts', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2013, pp 343
Publisher(s): Trinity College (Dublin, Ireland). School of Chemistry
Supervisor(s): Connon, Stephen
First Indexed: 2019-11-16 06:58:47 Last Updated: 2019-11-16 06:58:47