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A synthetic and photophysical study of ruthenium polypyridyl enantiomers binding to DNA
O'Sullivan, Kyra
THESIS 9737 The luminescent ONA probe [Ru(phen)2dppz]2+, ruthenium (bis-1,10-phenanthroline dipyrido[3,2-a:2',3'-c]phenazine, was the first tris-bidentate ruthenium complex to be shown unequivocally to intercalate to DNA, which it achieves via insertion of the extended dppz ligand. This complex has demonstrated its potential as a DNA probe, courtesy of its luminescent 'light-switch on' effect. Since its discovery and subsequent resolution into its constituent A and ? enantiomers, many analogues of the [Ru(phen)2dppz]2+ complex have been synthesised and scrutinised for any potential attributes. One such analogue is [Ru(TAP)2dppz]2+ ruthenium (bis,-1,4,5,8- tetraazaphenanthrene dipyrido[3,2-a;2',3'-c]phenazine, which demonstrates the 'lightswitch off' effect and is sufficiently oxidising in its 3MLCT excited state to cause photooxidative damage to DNA, leading to strand scission.
Keyword(s): Chemistry, Ph.D.; Ph.D. Trinity College Dublin.
Publication Date:
2012
Type: Doctoral thesis
Peer-Reviewed: Unknown
Language(s): English
Institution: Trinity College Dublin
Citation(s): Kyra O'Sullivan, 'A synthetic and photophysical study of ruthenium polypyridyl enantiomers binding to DNA', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2012, pp 414
Publisher(s): Trinity College (Dublin, Ireland). School of Chemistry
Supervisor(s): Kelly, John
First Indexed: 2019-11-16 06:58:49 Last Updated: 2019-11-29 07:14:09