Institutions | About Us | Help | Gaeilge
rian logo


Mark
Go Back
Optimal metabolic regulation by temporal variation of enzyme activities: a control theoretic approach
Oyarzun, Diego; Ingalls, Brian; Kalamatianos, Dimitrios
In this paper we use an optimal control approach to analyze time dependent enzyme concentrations that minimize the transition time of a metabolic pathway while respecting the natural constraints imposed by a limited biosynthetical capacity. Our main result states that, under appropriate assumptions, at each time instant all the available enzyme production capacity is allocated to a single reaction, a finding reminiscent of bang-bang control laws typical in classical time-optimal control.
Keyword(s): Hamilton Institute; Metabolic pathways; metabolic regulation; optimal control
Publication Date:
2007
Type: Journal article
Peer-Reviewed: Yes
Institution: Maynooth University
Citation(s): Oyarzun, Diego and Ingalls, Brian and Kalamatianos, Dimitrios (2007) Optimal metabolic regulation by temporal variation of enzyme activities: a control theoretic approach. Proceedings of the Foundations of Systems Biology in Engineering Conference, Stuttgart, Germany. FOSBE 2007 . pp. 491-496.
File Format(s): application/pdf
Related Link(s): http://mural.maynoothuniversity.ie/2119/1/DK_oyarzun_etal07c.pdf
First Indexed: 2020-01-31 06:02:03 Last Updated: 2020-04-02 07:38:53