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Increased immune cell infiltration in patient-derived tumor explants treated with Traniplatin: an original Pt(iv) pro-drug based on Cisplatin and Tranilast |
Lo Re, Daniele; Montagner, Diego; Tolan, Dina; Di Sanza, Claudio; Iglesias, Mar; Calon, Alexandre; Giralt, Ernest
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Elevated intra-tumoral immune infiltrate is associated with an improved prognosis in cancer of distinct origins. Traniplatin (TPT) is a novel platinum(IV) pro-drug based on Cisplatin (CDDP) and the marketed drug Tranilast. When compared in vitro to Cisplatin, TPT showed increased cytotoxic activity against colon and lung cancer cells but decreased activity against immune cells. In addition, TPT efficiency was evaluated in tumor explants derived from colorectal cancer samples from patients subjected to intended curative surgery. TPT induced strong intra-tumoral cytotoxic activity yet was associated with an elevated presence of immune cell infiltrate, suggesting a reduced cytotoxic activity against immune cells in colorectal cancer.
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Keyword(s):
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Cancer Cells; Stage II; Platinum; Complexes; Satraplatin; Survival; Localization; Mechanisms; Expression; Resistance |
Publication Date:
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2018 |
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Type:
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Journal article |
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Peer-Reviewed:
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Yes |
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Institution:
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Maynooth University |
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Citation(s):
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Lo Re, Daniele and Montagner, Diego and Tolan, Dina and Di Sanza, Claudio and Iglesias, Mar and Calon, Alexandre and Giralt, Ernest (2018) Increased immune cell infiltration in patient-derived tumor explants treated with Traniplatin: an original Pt(iv) pro-drug based on Cisplatin and Tranilast. Chemical Communications, 54 (60). pp. 8324-8327. ISSN 1359-7345 |
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Publisher(s):
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Royal Society of Chemstry |
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File Format(s):
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other |
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Related Link(s):
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http://mural.maynoothuniversity.ie/12579/1/Montagner_Traniplatin_2018.pdf |
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First Indexed:
2020-04-02 06:00:26 Last Updated:
2020-04-02 06:00:26 |
