Institutions | About Us | Help | Gaeilge
rian logo


Mark
Go Back
Increased immune cell infiltration in patient-derived tumor explants treated with Traniplatin: an original Pt(iv) pro-drug based on Cisplatin and Tranilast
Lo Re, Daniele; Montagner, Diego; Tolan, Dina; Di Sanza, Claudio; Iglesias, Mar; Calon, Alexandre; Giralt, Ernest
Elevated intra-tumoral immune infiltrate is associated with an improved prognosis in cancer of distinct origins. Traniplatin (TPT) is a novel platinum(IV) pro-drug based on Cisplatin (CDDP) and the marketed drug Tranilast. When compared in vitro to Cisplatin, TPT showed increased cytotoxic activity against colon and lung cancer cells but decreased activity against immune cells. In addition, TPT efficiency was evaluated in tumor explants derived from colorectal cancer samples from patients subjected to intended curative surgery. TPT induced strong intra-tumoral cytotoxic activity yet was associated with an elevated presence of immune cell infiltrate, suggesting a reduced cytotoxic activity against immune cells in colorectal cancer.
Keyword(s): Cancer Cells; Stage II; Platinum; Complexes; Satraplatin; Survival; Localization; Mechanisms; Expression; Resistance
Publication Date:
2018
Type: Journal article
Peer-Reviewed: Yes
Institution: Maynooth University
Citation(s): Lo Re, Daniele and Montagner, Diego and Tolan, Dina and Di Sanza, Claudio and Iglesias, Mar and Calon, Alexandre and Giralt, Ernest (2018) Increased immune cell infiltration in patient-derived tumor explants treated with Traniplatin: an original Pt(iv) pro-drug based on Cisplatin and Tranilast. Chemical Communications, 54 (60). pp. 8324-8327. ISSN 1359-7345
Publisher(s): Royal Society of Chemstry
File Format(s): other
Related Link(s): http://mural.maynoothuniversity.ie/12579/1/Montagner_Traniplatin_2018.pdf
First Indexed: 2020-04-02 06:00:26 Last Updated: 2020-04-02 06:00:26