Institutions | About Us | Help | Gaeilge
rian logo


Mark
Go Back
Combined fMRI and metabolic voltammetry in vivo: understanding the neurochemical basis of functional imaging signals
Sibson, Nicola R.; McHugh, S.; Lowry, John P.
Objectives:The use of functional magnetic resonance imaging (fMRI) in both basic and clinical neuroscience is rapidly expanding. However, although advance shave been made in correlating fMRI responses with the underlying neuronal activity, the fact remains that this technique does not directly measure neuronal activity but associated haemodynamic (and metabolic)events. Moreover, a constant relationship between neuronal, haemodynamic and metabolic processes across different brain regions is frequently assumed,despite substantial differences in neuronal architecture.Only by fully understanding the relationship between these parameters will we be able to fully utilise functional neuroimaging. Therefore, we must find away of correlating fMRI data, which largely reflects the haemodynamic component,with neural and/or meta-bolic information. Long-term in-vivo electrochemistry(LIVE) enables real-time measurement of brain metabolites.1In this study we have developed methods for simultaneous fMRI and tissue oxygen measurements via LIVE for direct correlation of metabolic and haemodynamic factors...
Keyword(s): Brain Imaging; MRI/fMRI
Publication Date:
2009
Type: Journal article
Peer-Reviewed: Yes
Institution: Maynooth University
Citation(s): Sibson, Nicola R. and McHugh, S. and Lowry, John P. (2009) Combined fMRI and metabolic voltammetry in vivo: understanding the neurochemical basis of functional imaging signals. Journal of Cerebral Blood Flow & Metabolism, 29 (1_Supp). pp. 613-614. ISSN 0271-678X
Publisher(s): SAGE Publications
File Format(s): other
Related Link(s): https://mural.maynoothuniversity.ie/12549/1/Lowry_CombinedfMRI_2009.pdf
First Indexed: 2020-04-02 06:00:44 Last Updated: 2021-07-31 06:54:57