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Evaluation of in vitro and in vivo antibacterial activity of novel
Cu(II)-steroid complexes |
Barrett, Stephen; Delaney, Stephen; Kavanagh, Kevin; Montagner, Diego
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A pioneer series of copper(II) complexes bearing planar phenanthroline-modified aromatic ligands and
steroid (ethynylestradiol and ethisterone) with generic formula [Cu(N \ N)(steroid)](NO3)2 where
N \ N is DPQ, DPPZ and DPPN and steroid is estradiol or testosterone, were synthetized, characterised
and screened in vitro and in vivo as antimicrobial agents against Staphylococcus aureus and methicillin
resistant Staphylococcus aureus (MRSA). Toxicity studies revealed notable antibacterial activity of the
copper – based compounds, which is significantly increased in vivo by the presence of the steroid moiety.
Toxicity profiling was estimated in vitro versus Gram-positive (Staphylococcus aureus) and MRSA and
in vivo in Galleria mellonella larvae infected with S. aureus. Results showed the complexes to be active
against S. aureus and MRSA in vitro (MIC50 average value of 2.46 and 97 lM in S. aureus and MRSA,
respectively) and to be active when larvae infected with S. aureus were administered the agents.
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Keyword(s):
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Copper(II); Phenanthroline; Steroids; Antimicrobial; In vivo |
Publication Date:
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2018 |
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Type:
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Journal article |
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Peer-Reviewed:
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Yes |
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Institution:
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Maynooth University |
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Citation(s):
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Barrett, Stephen and Delaney, Stephen and Kavanagh, Kevin and Montagner, Diego (2018) Evaluation of in vitro and in vivo antibacterial activity of novel Cu(II)-steroid complexes. Inorganica Chimica Acta, 479. pp. 261-265. ISSN 0020-1693 |
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Publisher(s):
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Elsevier |
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File Format(s):
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other |
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Related Link(s):
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http://mural.maynoothuniversity.ie/12439/1/KK_Evaluation%20of%20in%20vitro.pdf |
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First Indexed:
2020-04-02 06:01:30 Last Updated:
2020-04-02 06:01:30 |
