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A Cu(II) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights
Montagner, Diego; Fresch, B.; Browne, K.; Gandin, Valentina; Erxleben, Andrea
A new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr2(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods.
Keyword(s): Cu(II) complex; translocator protein; antitumor potential
Publication Date:
2017
Type: Journal article
Peer-Reviewed: Yes
Institution: Maynooth University
Citation(s): Montagner, Diego and Fresch, B. and Browne, K. and Gandin, Valentina and Erxleben, Andrea (2017) A Cu(II) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights. Chemical Communications, 53 (1). pp. 134-137. ISSN 1364-548X
Publisher(s): Royal Society of Chemistry
File Format(s): other
Related Link(s): http://mural.maynoothuniversity.ie/10753/1/DM-Translocator-Protein-2017.pdf
First Indexed: 2020-04-02 06:13:17 Last Updated: 2020-04-02 06:13:17