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Designing sensitive and selective polymer/enzyme composite biosensors for brain monitoring in vivo
O'Neill, Robert D.; Rocchitta, Gaia; McMahon, Colm P.; Serra, Pier A.; Lowry, John P.
Amperometric polymer/enzyme composite (PEC) biosensors, incorporating a poly(o-phenylenediamine) ultra-thin permselective barrier, possess a variety of characteristics that make them suitable for monitoring brain energy and neurotransmitter dynamics in vivo. This review highlights PEC sensitivity and selectivity parameters, which allow development of the basic design in a systematic way in order to improve their performance and to diversify the analyte range of these novel probes of brain function.
Keyword(s): Ascorbic acid interference; Brain monitoring; Electropolymerization; Glucose; Glutamate; H2O2 permeability; Polymer-modified electrode
Publication Date:
2008
Type: Journal article
Peer-Reviewed: Yes
Institution: Maynooth University
Citation(s): O'Neill, Robert D. and Rocchitta, Gaia and McMahon, Colm P. and Serra, Pier A. and Lowry, John P. (2008) Designing sensitive and selective polymer/enzyme composite biosensors for brain monitoring in vivo. TrAC Trends in Analytical Chemistry, 27 (1). pp. 78-88. ISSN 0165-9936
Publisher(s): Elsevier
File Format(s): other
Related Link(s): https://mural.maynoothuniversity.ie/8034/1/JL-Designing-2008.pdf
First Indexed: 2020-04-02 06:33:03 Last Updated: 2021-07-31 08:01:24