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A Slow Axon Antidromic Blockade Hypothesis for Tremor Reduction via Deep Brain Stimulation
García, Míriam R.; Pearlmutter, Barak A.; Wellstead, Peter E.; Middleton, Richard H.
Parkinsonian and essential tremor can often be effectively treated by deep brain stimulation. We propose a novel explanation for the mechanism by which this technique ameliorates tremor: a reduction of the delay in the relevant motor control loops via preferential antidromic blockade of slow axons. The antidromic blockade is preferential because the pulses more rapidly clear fast axons, and the distribution of axonal diameters, and therefore velocities, in the involved tracts, is sufficiently long-tailed to make this effect quite significant. The preferential blockade of slow axons, combined with gain adaptation, results in a reduction of the mean delay in the motor control loop, which serves to stabilize the feedback system, thus ameliorating tremor. This theory, without any tuning, accounts for several previously perplexing phenomena, and makes a variety of novel predictions.
Keyword(s): Slow Axon Antidromic Blockade Hypothesis; Tremor Reduction; Deep Brain Stimulation
Publication Date:
Type: Journal article
Peer-Reviewed: Yes
Institution: Maynooth University
Citation(s): García, Míriam R. and Pearlmutter, Barak A. and Wellstead, Peter E. and Middleton, Richard H. (2013) A Slow Axon Antidromic Blockade Hypothesis for Tremor Reduction via Deep Brain Stimulation. PLoS ONE, 8 (9). e73456. ISSN 1932-6203
Publisher(s): Public Library of Science
File Format(s): other
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First Indexed: 2020-04-02 06:43:20 Last Updated: 2020-04-02 06:43:20