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3D Printed Sugar-Sensing Hydrogels
Florea, Larisa; Bruen, Danielle; Delaney, Colm; Chung, Johnson; Ruberu, Kalani; Wallace, Gordon G.; Diamond, Dermot
The ability of boronic acids to reversibly bind diols, such as sugars, has been widely studied in recent years. In solution, through the incorporation of additional fluorophores, this boronic acid-sugar interaction can be monitored by changes in fluorescence. Ultimately, a practical realization of this technology requires a transition from solution-based methodologies. Herein we present the first example of 3D printed sugar-sensing hydrogels, achieved through the incorporation of a boronic acid-fluorophore pair in a gelatin methacrylamide-based matrix. Through optimization of monomeric cocktails, it was possible to use extrusion printing to generate structured porous hydrogels which show a measurable and reproducible linear fluorescence response to glucose and fructose up to 100 mM.
Keyword(s): Hydrogels; Boronic acid; 3D printing; Fluorescence; Nanoscience & Materials; Next Generation Medical Devices; Biopolymeric Materials; HYDROGEL; PHOTO-POLYMERISATION; POLYMER; Polymer Chemistry; SENSING; sugar sensing
Publication Date:
2020
Type: Journal article
Peer-Reviewed: Yes
Language(s): English
Institution: Trinity College Dublin
Citation(s): Bruen, D., Delaney, C., Chung, J., Ruberu, K., Wallace, G.G. & Florea, L., 3D Printed Sugar-Sensing Hydrogels, 2020, Macromolecular Rapid Communications
Related Link(s): https://onlinelibrary.wiley.com/doi/abs/10.1002/marc.201900610
First Indexed: 2020-04-19 07:22:16 Last Updated: 2020-04-19 07:22:16