Institutions | About Us | Help | Gaeilge
rian logo


Mark
Go Back
Cervico-vaginal mucus (CVM) – an accessible source of immunologically informative biomolecules
Adnane, Mounir; Meade, Kieran G; O’Farrelly, Cliona
Cervico-vaginal mucus (CVM), the product of epithelial cells lining the uterus, cervix and vagina, is secreted to facilitate uterine lubrication and microbial clearance. Predominantly composed of water and mucins, CVM also contains high levels of immuno-active proteins such as immunoglobulin A (IgA), lactoferrin and lysozyme which protect against infection by blocking adhesion and mediating microbial killing. The repertoire of cytokines, chemokines and antimicrobial peptides is predominantly generated by the secretions of endometrial epithelial cells into the uterine lumen and concentrated in the CVM. The quantity and relative proportions of these inflammatory biomarkers are affected by diverse factors including the estrus cycle and health status of the animal and therefore potentially provide important diagnostic and prognostic indicators. We propose that measuring molecular signatures in bovine CVM could be a useful approach to identifying and monitoring genital tract pathologies in beef and dairy cows.
Keyword(s): Cervico-vaginal mucus; Diagnosis; Biomarkers; Inflammation
Publication Date:
2020
Type: Other
Peer-Reviewed: Yes
Language(s): English
Contributor(s): Science Foundation Ireland; Health Research Board; Department of Agriculture, Food and the Marine; 12/Ia/1667; HRA_POR/2012/37; FIRM/ RSF/CoFoRD 2013–2016: ENRICH; FIRM/RSF/CoFoRD 2011-2015
Institution: Teagasc
Citation(s): 42
4
255-263
Publisher(s): Springer Science and Business Media LLC
First Indexed: 2020-08-21 07:14:11 Last Updated: 2020-08-25 07:21:58