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The Impact of Formulation on Lutein, Zeaxanthin, and meso-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study
Green-Gomez, Marina; Prado-Cabrero, Alfonso; Moran, Rachel; Power, Tommy; Gómez Gómez-Mascaraque, Laura; Stack, Jim; Nolan, John N.
Lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) have been the focus of research and commercial interest for their applications in human health. Research into formulations to enhance their bioavailability is merited. This 6 month randomised placebo-controlled trial involving 81 healthy volunteers compared the bioavailability of different formulations of free L, Z, and MZ in sunflower or omega-3 oil versus L, Z, and MZ diacetates (Ld, Zd, and MZd) in a micromicellar formulation. Fasting serum carotenoids, macular pigment, and skin carotenoid score were analysed at baseline and 6 months. Serum L, Z, and MZ concentrations increased in all active interventions compared to placebo (p < 0.001 to p = 0.008). The diacetate micromicelle formulation exhibited a significantly higher mean response in serum concentrations of Z and MZ compared to the other active interventions (p = 0.002 to 0.019). A micromicellar formulation with solubilised Z and MZ diacetates is a promising technology advancement that enhances the bioavailability of these carotenoids when compared to traditional carotenoid formulations (ISRCTN clinical trial registration number: ISRCTN18206561)
Keyword(s): meso-zeaxanthin; Zeaxanthin; Lutein; carotenoid diacetates; bioavailability; micromicelles
Publication Date:
2020
Type: Other
Peer-Reviewed: Yes
Language(s): English
Contributor(s): Howard Foundation UK; Waterford Institute of Technology (WIT) President’s scholarship program
Institution: Teagasc
Citation(s): 9
8
767
Antioxidants
Publisher(s): MDPI AG
First Indexed: 2020-11-04 07:09:35 Last Updated: 2020-11-04 07:09:35