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Augmentation of Macular Pigment Following Supplementation with all Three Macular Carotenoids: an Exploratory Study
Connolly, Eithne; Beatty, Stephen; Thurnham, David; Loughman, James; Howard, Alan; Stack, Jim; Nolan, John
Purpose:At the macula, the carotenoids meso-zeaxanthin (MZ), lutein (L), and zeaxanthin (Z) are collectively referred to as macular pigment (MP). This study was designed to measure serum and macular responses to a macular carotenoid formulation. Materials and Methods:Ten subjects were recruited into this study (five normal and five with early age-related macular degeneration [AMD]). Subjects were instructed to consume a formulation containing 7.3mg of MZ, 3.7mg of L, and 0.8mg of Z everyday over an eight-week period. The spatial profile of MP optical density (i.e., MPOD at 0.25°, 0.5°, 1°, and 1.75°) was measured using customized heterochromatic flicker photometry, and a blood sample was collected at each study visit in order to analyze serum concentrations of MZ, L, and Z. Results:There was a significant increase in serum concentrations of MZ and L after two weeks of supplementation (p
Keyword(s): age-related macular degeneration; Lutein; macular pigment; meso-zeaxanthin; supplementation; Optometry
Publication Date:
Type: Journal article
Peer-Reviewed: Unknown
Contributor(s): Howard Foundation, Cambridge, United Kingdom
Institution: Dublin Institute of Technology
Citation(s): Articles
Publisher(s): Dublin Institute of Technology
File Format(s): application/pdf
First Indexed: 2010-07-21 05:36:19 Last Updated: 2017-12-14 07:08:21