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Analysing chem/bio-Markers in saliva using a portable optical detection platform
Coleman, Simon; Kavanagh, Andrew; Orpen, Dylan; Kim, Jung Ho; Lau, King-Tong; Diamond, Dermot
Bipolar Disorder is commonly regulated using a varying dosage of Lithium carbonate and monitored by blood analysis. The proximity of the upper dosage level in blood (1.2mmol), to that of toxicity (>1.5mmol), presents a risk for patient wellbeing from overdose. The infrequency of blood testing creates a potential for overdose to occur between sampling and remain undetected. Additionally, the invasive and often painful nature of frequent blood draws has resulted in the search for alternative non-invasive techniques. One such medium is saliva and we describe the use of simple, well established, optical techniques integrated into a portable wireless device to analyze Chemical and Bio-markers present in this medium. This novel device allows for frequent, real-time monitoring of drug levels (Lithium) and patient psychological state (alpha-amylase) as well as supplementing patient assessments with their Physician and giving the patient a more personalised monitoring of their health during Lithium treatment.
Keyword(s): Photochemistry; Electronic circuits; Optoelectronics; Chemical detectors; Biology; Detectors; Photonics; Biosensors; Chemistry
Publication Date:
2012
Type: Other
Peer-Reviewed: Unknown
Language(s): English
Institution: Dublin City University
File Format(s): application/pdf
Related Link(s): http://doras.dcu.ie/17115/
First Indexed: 2012-07-10 05:06:17 Last Updated: 2018-10-27 06:51:11