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Genetic channel capacity revisited
Balado, Félix
Bionetics 2011, 6th International ICST Conference on Bio-Inspired Models of Network, Information, and Computing Systems, 5-6 December 2011, York, England We revisit previous analyses on the computation of the maximum mutual information between a genetic sequence and its mutated versions down the generations, taking into account the protein translation mechanism of the genetic machinery. This amounts to the application of Shannon's capacity to the study of the transmission of genetic information. Studies on this subject were started by Yockey and then followed by a number of researchers. Here we refine prior analyses employing the Kimura model of base substitution mutations, which is more realistic than the Jukes-Cantor model used by all previous research on this topic. Furthermore we undertake exact computations where prior works just used approximations, and we propose two practical applications of genetic capacity. Science Foundation Ireland Conference details http://www.bionetics.org/ Check if published then EMBARGO for 12 months - OR 16/12/11 12M embargo - NYP, should appear in LNICST http://icst.org/lnicst-guidelines-for-authors/ - AV 15/11/2011 ti - kpw2/12/11
Keyword(s): Information theory; Genetic channel capacity; Molecular genetics; Mutation (Biology)
Publication Date:
2011
Type: Other
Peer-Reviewed: Unknown
Language(s): English
Institution: University College Dublin
Publisher(s): Springer
File Format(s): other; application/pdf
First Indexed: 2012-08-25 05:16:22 Last Updated: 2018-10-11 16:07:19