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Role of Genomics and RNA-seq in Studies of Fungal Virulence
Riccombeni, Alessandro; Butler, Geraldine
Since its introduction in the last decade, massive parallel sequencing, or “next-generation sequencing”, has revolutionized our access to genomic information, providing accurate data with increasingly higher yields and lower costs with respect to first-generation technology. Massive parallel sequencing of cDNA, or RNA-seq, is progressively replacing array-based technology as the method of choice for transcriptomics. This review describes some of the most recent applications of next-generation sequencing technology to the study of pathogenic fungi, including Candida, Aspergillus and Cryptococcus species. Several integrated approaches illustrate the power and accuracy of RNA-seq for studying the biology of human fungal pathogens. In addition, the lack of consistency in data analysis is discussed. Author has checked copyright DG - 10/10/2012 Item not published yet and only available online as part of "Online First" feature. I'm not sure when it's due to published so i've set the check date to Jan 2013. Also, there is a 12 month publishing embargo - DG 10/10/12
Keyword(s): Aspergillus; Bioinformatics; Candida; ChIP-seq; Cryptococcus; Dermatophytes; Genomics; Next-generation sequencing; RNA-seq; Nucleotide sequence
Publication Date:
2012
Type: Journal article
Peer-Reviewed: Unknown
Language(s): English
Institution: University College Dublin
Publisher(s): Springer
First Indexed: 2012-10-16 05:15:20 Last Updated: 2018-10-11 15:51:37