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Synthesis and characterisation of novel ferrocenyl thienyl and thiazolyl systems
Alley, Steven; Gallagher, John F.; Hooper, Vincent M.; Kenny, Peter T.M.; Lough, Alan J.
Ferrocenyl derivatives are currently under investigation by our group and several series containing both amidothienyl and amidothiazolyl systems have been synthesised and characterised. The incorporation of thienyl/thiazolyl groups into a ferrocenyl- or ferrocenylphenyl system greatly enhances the number of potential donor atoms for coordination with metal fragments e.g. PtII, PdII with a view to platinum anti-cancer studies and/or interaction with guest molecules through suitable hydrogen bonding interactions. In nature, thiazole has been found to be vital in certain natural products: examples include the antibiotic bacitracin and the siderophore yersiniabactin. In therapeutic studies the antitumour compound epothilone A and myxothiazole (inhibitor) have been extensively studied.
Keyword(s): Inorganic chemistry; Chemistry; Crystallography; Ferrocenyl derivatives
Publication Date:
2005
Type: Other
Peer-Reviewed: Unknown
Language(s): English
Institution: Dublin City University
Citation(s): Alley, Steven, Gallagher, John F. ORCID: 0000-0003-4130-4556 <https://orcid.org/0000-0003-4130-4556>, Hooper, Vincent M., Kenny, Peter T.M. and Lough, Alan J. (2005) Synthesis and characterisation of novel ferrocenyl thienyl and thiazolyl systems. In: ACA meeting, 17-22 Jul 2005, Chicago, USA.
File Format(s): application/pdf
Related Link(s): http://doras.dcu.ie/17915/1/Chicago_Poster_2005.pdf
First Indexed: 2013-03-29 05:25:08 Last Updated: 2019-02-09 06:37:49