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Understanding the p-toluenesulfonamide / triphenylphosphine oxide crystal chemistry: a new 1:1 cocrystal and ternary phase diagram |
Croker, Denise M.; Foreman, Michael E.; Hogan, Bridget N.; Maguire, Nuala M.; Elcoate, Curtis J.; Hodnett, Benjamin K.; Maguire, Anita R.; Rasmuson, Åke C.; Lawrence, Simon E.
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A novel 1:1 cocrystal between p-toluenesulfonamide and triphenylphosphine oxide has been prepared and structurally characterized. This 1:1 cocrystal was observed to form during solid state grinding experiments, with subsequent formation of a known 3:2 cocrystal in the presence of excess sulfonamide. Both cocrystals are stable in the solid state. The ternary phase diagram for the two coformers was constructed in two different solvents: acetonitrile and dichloromethane. Examination of these diagrams clarified solution crystallization of both the newly discovered 1:1 cocrystal and the previously reported 3:2 cocrystal, and identified regions of stability for each cocrystal in each solvent. The choice of solvent was found to have a significant effect on the position of the solid state regions within a cocrystal system.
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Keyword(s):
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cocrystal system; crystallography; chemistry |
Publication Date:
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2012 |
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Type:
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Journal article |
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Peer-Reviewed:
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Yes |
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Language(s):
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English |
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Institution:
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University of Limerick |
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Funder(s):
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Science Foundation Ireland |
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Citation(s):
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Crystal Growth and Design;12(2), pp. 869-875
http://dx.doi.org/10.1021/cg201300e
07/SRC/B1158
05/PICA/B808/EC07 |
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Publisher(s):
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American Chemical Society |
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First Indexed:
2013-05-01 05:33:06 Last Updated:
2018-08-09 06:43:08 |
