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Measuring the solubility of a quickly transforming metastable polymorph of carbamazepine
O'Mahony, Marcus A; Croker, Denise M.; Rasmuson, Åke C.; Vesler, Stéphane; Hodnett, Benjamin K.
The solubility of the stable FIII polymorph of the pharmaceutical compound carbamazepine was measured by determining its solubility gravimetrically in ethanol and methanol. Where the metastable FI polymorph was suspended in a solution of ethanol, the stable FIII polymorph nucleated immediately initiating a solution mediated transformation from FI to FIII. This meant that the FI polymorph was not in thermodynamic equilibrium with the solution as FI was continually dissolving while FIII was growing. We show that the solubility of FI can be accurately measured by in situ microscopy using an adaption of the bracketing method and the results show that the solubility is close to but higher than the maximum solution concentration reached during the solution mediated transformation from FI to FIII carbamazepine in both solvents. The technique demonstrates a relatively simple and robust method for determining the solubility of a metastable crystalline phase which transforms quickly in solution.
Keyword(s): carbamazepine; pharmaceuticals
Publication Date:
2012
Type: Journal article
Peer-Reviewed: Yes
Language(s): English
Institution: University of Limerick
Funder(s): Science Foundation Ireland
Citation(s): Organic Process Research & Development;17(3), pp. 512-518
http://dx.doi.org/10.1021/op300228g
07/SRC/B1158
Publisher(s): American Chemical Society
First Indexed: 2013-05-02 05:33:28 Last Updated: 2018-02-25 06:36:02