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Gastric T lymphocyte responses to Helicobacter pylori in patients with H pylori colonisation
peer-reviewed Helicobacter pylori has been identified as a dominant factor in the pathogenesis of duodenal ulcer. The aim of this study was to examine peripheral blood and gastric lymphocyte proliferation and cytokine production in patients with H pylori colonisation. Sixty five dyspeptic patients attending for endoscopy were studied; 35 of these were H pylori positive and 30 H pylori negative as assessed by culture, histology, and rapid urease test. H pylori antigen was capable of stimulating peripheral blood lymphocyte proliferative responses even in H pylori negative patients. Peripheral blood lymphocyte proliferative responses to H pylori (but not to purified protein derivative or phythaemagglutinin) were significantly lower in H pylori positive than H pylori negative patients. Similarly, antigen specific proliferative responses and interferon gamma production by gastric lamina propria lymphocytes were also depressed in H pylori positive patients compared with H pylori negative patients. CD8 and CD22 positive lamina propria lymphocytes were increased in H pylori positive patients. These data show that antigen specific responses to H pylori are significantly lower in H pylori positive patients and could indicate activation of antigen specific suppression.
Keyword(s): Clinical Medicine
Publication Date:
Type: Journal article
Peer-Reviewed: Yes
Language(s): English
Institution: Trinity College Dublin
Citation(s): X. J. Fan, A. Chua, C. N. Shahi, J. McDevitt, P. W. Keeling and D. Kelleher `Gastric T lymphocyte responses to Helicobacter pylori in patients with H pylori colonisation? in Gut, 35, (10), 1994, pp 1379-1384
Publisher(s): BMJ
File Format(s): application/pdf
First Indexed: 2014-05-13 05:27:16 Last Updated: 2015-04-10 05:21:52