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NF-κB regulation: The nuclear response |
GRAY, STEVEN; LAWLESS, MATTHEW; KELLEHER, DERMOT; MANKAN, ARUN KUMAR; MCMANUS, ROSS
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Nuclear factor ?B (NF-?B) is an inducible transcription factor that tightly regulates the expression of a large cohort of genes. As a key component of the cellular machinery NF-?B is involved in a wide range of biological processes including innate and adaptive immunity, inflammation, cellular stress responses, cell adhesion, apoptosis and proliferation. Appropriate regulation of NF-?B is critical for the proper function and survival of the cell. Aberrant NF-?B activity has now been implicated in the pathogenesis of several diseases ranging from inflammatory bowel disease to autoimmune conditions such as rheumatoid arthritis. Systems governing NF-?B activity are complex and there is an increased understanding of the importance of nuclear events in regulating NF-?B's activities as a transcription factor. A number of novel nuclear regulators of NF-?B such asI?B-? and PDZ and LIM domain 2 (PDLIM2) have now been identified, adding another layer to the mechanics of NF-?B regulation. Further insight into the functions of these molecules raises the prospect for better understanding and rational design of therapeutics for several important diseases.
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Keyword(s):
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Oncology; Immunology; NF-kappa B; Nuclear Regulation |
Publication Date:
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2009 |
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Type:
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Journal article |
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Peer-Reviewed:
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Yes |
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Language(s):
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English |
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Institution:
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Trinity College Dublin |
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Citation(s):
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Mankan, A.K., Lawless, M.W., Gray, S.G., Kelleher, D., McManus, R., NF-κB regulation: The nuclear response , Journal of Cellular and Molecular Medicine, 13, 4, 2009, 631-643 |
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First Indexed:
2014-05-13 05:53:23 Last Updated:
2017-04-26 11:01:08 |
