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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
FEIGHERY, CONLETH FRANCIS; KELLEHER, DERMOT P; MCMANUS, ROSS
peer-reviewed We tested 310,605 single-nucleotide polymorphisms for association in 778 celiac disease cases and 1422 controls. Outside the HLA, the most significant finding (rs13119723, P=2.0 ? 10?7, empirical genome-wide significance P=0.045) was in the KIAA1109/Tenr/IL2/IL21 linkage disequilibrium block. Association was independently confirmed in two further collections (strongest at rs6822844, 24kB 5' of IL21, meta-analysis P=1.3 ? 10?14, OR 0.63), suggesting genetic variation in this region predisposes to celiac disease.
Keyword(s): Clinical Medicine
Publication Date:
2007
Type: Journal article
Peer-Reviewed: Yes
Language(s): English
Institution: Trinity College Dublin
Funder(s): Science Foundation Ireland
Citation(s): van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MC, Bethel G, Holmes GK, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, Walters JR, Sanders DS, Howdle P, Swift J, Playford RJ, McLaren WM, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon LR `A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21? in Nature Genetics, 39, (7), 2007, pp 827 - 829
Publisher(s): Nature
File Format(s): application/pdf
First Indexed: 2014-05-13 05:53:35 Last Updated: 2017-04-26 11:05:01