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Displaying Results 26 - 50 of 301 on page 2 of 13

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Release of HMGB1 in response to pro-apoptotic glioma killing strategies: efficacy and neurotoxicity (2010)

Candolfi, Marianela; Yagiz, Kader; Foulad, David; Alzadeh, Gabrielle E; Tesarfreund, Ma...

Release of HMGB1 in response to pro-apoptotic glioma killing strategies: efficacy and neurotoxicity (2010)

Candolfi, Marianela; Yagiz, Kader; Foulad, David; Alzadeh, Gabrielle E; Tesarfreund, Matthew; Muhammad, AKM Ghulam; Puntel, Mariana; Kroeger, Kurt M; Liu, Chunyan; Lee, Sharon; Curtin, James; King, Gwendalyn D; Lerner, Jonathan; Sato, Katsuaki; Mineharu, Yohei; Xiong, Weidong; Lowenstein, Pedro R; Castro, Maria G

Abstract:

Purpose In preparation for a Phase I clinical trial utilizing a combined cytotoxic/immunotherapeutic strategy using adenoviruses expressing Flt3L (Ad-Flt3L) and thymidine kinase (Ad-TK) to treat glioblastoma (GBM), we tested the hypothesis that Ad-TK+GCV would be the optimal tumor killing agent in relation to efficacy and safety when compared to other pro-apoptotic approaches. Experimental Design and Results The efficacy and neurotoxicity of Ad-TK+GCV was compared with Ads encoding the pro-apoptotic cytokines (TNF-α, TRAIL, FasL), alone or in combination with Ad-Flt3L. In rats bearing small GBMs (day 4), only Ad-TK+GCV or Ad-FasL improved survival. In rats bearing large GBMs (day 9), the combination of Ad-Flt3L with Ad-FasL did not improve survival over FasL alone, while Ad-Flt3L combined with Ad-TK+GCV led to 70% long-term survival. Expression of FasL and TRAIL caused severe neuropathology, which was not encountered when we utilized Ad-TK+/−Ad-Flt3L. In vitro, all treatments elicit...

Full-text link

http://arrow.dit.ie/scschbioart/54

Dublin Institute of Technology

Journal article

peer-reviewed

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Regulatable Gene Expression Systems for Gene Therapy Applications: Progress and Future Challenges (2005)

Goverdhana, Shyam; Puntel, Mariana; Xiong, Weidong; Zirger, Jeffrey; Barcia, Carlos; Cu...

Dublin Institute of Technology

Review

peer-reviewed

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Fish primary cultures for toxicity and pathological studies (1997)

Lyons Alcantara, Maria, (Thesis)

Dublin Institute of Technology

Doctoral thesis

peer-reviewed

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Development of an In Vitro Assay to predict patient response to radiotheraphy (1995)

Sheridan, Mary, (Thesis)

Dublin Institute of Technology

Doctoral thesis

peer-reviewed

Mark

Identification of fatty acid oxidation disorder patients with lowered acyl-CoA thioesterase activity in human skin fibroblasts (2005)

Hunt, Mary; Ruiter, Jos; Mooyer, Petra; van Roermond, Carlo W T; Ofman, Rob; Ijlst, Lod...

Dublin Institute of Technology

Journal article

peer-reviewed

Mark

The Peroxisome Proliferator-Activated Receptor Alpha (PPAR ) regulates Bile Acid Biosynthesis. (2000)

Hunt, Mary; Yang, Yi-Zeng; Eggertsen, Gosta; Carneheim, Claes; Gafvels, Mats; Einarsson...

Dublin Institute of Technology

Journal article

peer-reviewed

Mark

A peroxisomal acyltransferase in mouse identifies a novel pathway for taurine conjugation of fatty acids. (2007)

Reilly, Sarah-Jayne; O'Shea, Eithne; James, O'Byrne; Alexson, Stefan; Hunt, Mary

Dublin Institute of Technology

Journal article

peer-reviewed

Mark

Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARa) regulated peroxisomal acyl-CoA thioesterases. (2004)

Westin, Maria; Hunt, Mary; Alexson, Stefan

Dublin Institute of Technology

Journal article

peer-reviewed

Mark

Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (2006)

Hunt, Mary; Rautanen, Anna; Westin, Maria; Svensson, Thomas; Alexson, Stefan

Dublin Institute of Technology

Journal article

peer-reviewed

Mark

Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials. (2008)

Curtin, James; Candolfi, Marianela; Fakhouri, Tamer; Liu, Chunyan; Alden, Anderson; Edw...

Dublin Institute of Technology

Journal article

peer-reviewed

Mark

Anisomycin activates JNK and sensitises DU 145 prostate carcinoma cells to Fas mediated apoptosis (2002)

Curtin, James; Cotter, Thomas

Dublin Institute of Technology

Journal article

peer-reviewed

Mark

Regulation and measurement of oxidative stress in apoptosis (2002)

Curtin, James; Donovan, Maryanne; Cotter, Thomas

Dublin Institute of Technology

Review

peer-reviewed

Mark

Regulated Expression of Adenoviral Vectors-Based Gene Therapies: Therapeutic Expression of Toxins and Immune-Modulators (2008)

Curtin, James; Candolfi, Marianela; Puntel, Mariana; Xiong, Weidong; Muhammad, AKM Ghul...

Dublin Institute of Technology

Journal article

peer-reviewed

Mark

Historical perspectives (Apoptosis) (2003)

Curtin, James; Cotter, Thomas

Dublin Institute of Technology

Journal article

peer-reviewed

Mark

Turning the gene tap off; implications of regulating gene expression for cancer therapeutics (2008)

Curtin, James; Candolfi, Marianela; Xiong, Weidong; Lowenstein, Pedro; Castro, Maria

Dublin Institute of Technology

Review

peer-reviewed

Mark

Live and let die: regulatory mechanisms in Fas-mediated apoptosis (2003)

Curtin, James; Cotter, Thomas

Dublin Institute of Technology

Journal article

peer-reviewed

Mark

Isolation of cancer stem cells from adult glioblastoma multiforme (2004)

Yuan, Xianpeng; Curtin, James; Xiong, Yizhi; Liu, Gentao; Waschsmann-Hogiu, Sebastian; ...

Dublin Institute of Technology

Journal article

peer-reviewed

Mark

Transcriptional regulation of cholesterol 24-hydroxylase by histone deacetylase inhibitors. (2009)

Shafaati, Marjan; O'Driscoll, Riona; Bjorkhem, Ingemar; Meaney, Steve

Dublin Institute of Technology

Journal article

peer-reviewed

Mark

Peroxisomes Contain a Specific Phytanoly-CoA/Pristanoyl-CoA Thioesterase Acting as a Novel Auxiliary Enzyme in Alpha-and Beta-Oxidation of Methyl-Branched Fatty Acids in Mouse (2007)

Westin, Maria; Hunt, Mary; Alexson, Stefan

Dublin Institute of Technology

Journal article

peer-reviewed

Mark

Transcriptional regulation of cholesterol 24-hydroxylase by histone deacetylase inhibitors. (2009)

Shafaati, Marjan; O'Driscoll, Riona; Bjorkhem, Ingemar; Meaney, Steve

Dublin Institute of Technology

Journal article

peer-reviewed

Mark

JNK Regulates HIPK3 Expression and Promotes Resistance to Fas-mediated Apoptosis in DU 145 Prostate Carcinoma Cells (2004)

Curtin, James; Cotter, Thomas

Dublin Institute of Technology

Journal article

peer-reviewed

Mark

Genetic connections between neurological disorders and cholesterol metabolism (2010)

Bjorkhem, Ingemar; Leoni, Valerio; Meaney, Steve

Dublin Institute of Technology

Journal article

peer-reviewed

Mark

Defects in death-inducing signalling complex formation prevent JNK activation and Fas-mediated apoptosis in DU 145 prostate carcinoma cells (2003)

Curtin, James; Cotter, Thomas

Dublin Institute of Technology

Journal article

peer-reviewed

Mark

Novel functions of acyl-CoA thioesterases and acyltransferases as auxiliary enzymes in peroxisomal lipid metabolism. (2008)

Hunt, Mary; Alexson, Stefan

Dublin Institute of Technology

Review

peer-reviewed

Mark

The nudix hydrolase 7 is an acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis. (2008)

Reilly, Sarah-Jayne; Tillander, Veronica; Ofman, Rob; Alexson, Stefan E H; Hunt, Mary C

Dublin Institute of Technology

Journal article

peer-reviewed

Displaying Results 26 - 50 of 301 on page 2 of 13

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