Cancer, a class of diseases, characterized by abnormal cell growth, has demonstrably high impact on human life: complex lifestyle changes, caused by malignancy, affect not only patients, but also family and friends. Cancer development has been linked to genetic and epigenetic abnormalities that affect the regulation of key genes that control cellular mechanisms. These alterations, which target stem cells, may be different or less immediately adverse from one person to another, as various risk factors are cumulative and variable in effect. However, a major issue in cancer research is the lack of precise information on tumour pathways; therefore the delineation of these and of the processes underlying disease proliferation is an important area of investigation.
Here, we present a hybrid computational model following a multi-scale approach, which has been developed for colorectal cancer dynamics by linking information from micromolecular to cellular and tissue levels, (e.g. epigenetic ...