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'Cancer' in all fields;
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Displaying Results 151 - 175 of 3622 on page 7 of 145
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Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer
(2015)
SHEILS, ORLA; O'LEARY, JOHN; GALLAGHER, MICHAEL; SPILLANE, CATHY
Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer
(2015)
SHEILS, ORLA; O'LEARY, JOHN; GALLAGHER, MICHAEL; SPILLANE, CATHY
Abstract:
Background: Ovarian cancer is associated with poor long-term survival due to late diagnosis and development of chemoresistance. Tumour hypoxia is associated with many features of tumour aggressiveness including increased cellular proliferation, inhibition of apoptosis, increased invasion and metastasis, and chemoresistance, mostly mediated through hypoxia-inducible factor (HIF)-1a?. While HIF-1a? has been associated with platinum resistance in a variety of cancers, including ovarian, relatively little is known about the importance of the duration of hypoxia. Similarly, the gene pathways activated in ovarian cancer which cause chemoresistance as a result of hypoxia are poorly understood. This study aimed to firstly investigate the effect of hypoxia duration on resistance to cisplatin in an ovarian cancer chemoresistance cell line model and to identify genes whose expression was associated with hypoxia-induced chemoresistance. Methods: Cisplatin-sensitive (A2780) and cisplatin-resista...
http://hdl.handle.net/2262/79191
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‘Moving on’ from cancer: the effects of engaging in a 12 week community-based exercise programme on cancer survivors’ physical and psychological well-being
(2016)
Cooney, Mairead; Woods, Catherine; Moyna, Niall; O'Leary, Emer; Furlong, Bróna; Wa...
‘Moving on’ from cancer: the effects of engaging in a 12 week community-based exercise programme on cancer survivors’ physical and psychological well-being
(2016)
Cooney, Mairead; Woods, Catherine; Moyna, Niall; O'Leary, Emer; Furlong, Bróna; Walsh, Deirdre; McCaffrey, Noel
Abstract:
Background: MedEx Wellness is a community-based chronic illness rehabilitation programme located at Dublin City University. It offers exercise classes in a medically supervised environment to patients with a range of chronic illnesses. MedEx ‘Move On’ is the oncology rehabilitation programme that caters for cancer survivors. This study aimed to determine the effect of ‘Move On’ on cancer survivors’ physical and psychological wellbeing. Methods: Adults with an established diagnosis of cancer, who have completed their adjunctive therapy, are referred to ‘Move On’. Participants attend two 60 minute supervised exercise classes per week for 12 weeks. Recruitment to the ‘Move On’ programme occurs every 12 weeks, with approximately 30 participants attending per cycle. Classes are led by exercise specialists and involve a combination of aerobic and resistance training. A single arm pre-test, post-test design was used. At baseline and week 12, assessments of cardiorespiratory fitness (10m sh...
http://doras.dcu.ie/21637/
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A theoretical framework to guide a study exploring cancer related fatigue
(2017)
O'Regan, Patricia; Landers, Margaret; Hegarty, Josephine
A theoretical framework to guide a study exploring cancer related fatigue
(2017)
O'Regan, Patricia; Landers, Margaret; Hegarty, Josephine
Abstract:
This paper explicates how Orem's Self-care Deficit Theory of Nursing (Orem, 1995) was selected to guide a study to explore and measure cancer related fatigue (CRF), and determine the most effective self-care strategies used to combat CRF in a cohort of patients with a diagnosis of cancer (breast cancer, colorectal cancer, Hodgkin's and Non-Hodgkin's lymphoma). The secondary aim was to explore self-care agency and its relationship to CRF.
http://hdl.handle.net/10468/4279
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Bioconjugated gold nanoparticles enhance cellular uptake: a proof of concept study for siRNA delivery in prostate cancer cells
(2016)
Guo, Jianfeng; O'Driscoll, Caitríona M.; Holmes, Justin D.; Rahme, Kamil
Bioconjugated gold nanoparticles enhance cellular uptake: a proof of concept study for siRNA delivery in prostate cancer cells
(2016)
Guo, Jianfeng; O'Driscoll, Caitríona M.; Holmes, Justin D.; Rahme, Kamil
Abstract:
The chemistry of gold nanoparticles (AuNPs) facilitates surface modifications and thus these bioengineered NPs have been investigated as a means of delivering a variety of therapeutic cargos to treat cancer. In this study we have developed AuNPs conjugated with targeting ligands to enhance cell-specific uptake in prostate cancer cells, with a purpose of providing efficient non-viral gene delivery systems in the treatment of prostate cancer. As a consequence, two novel AuNPs were synthesised namely AuNPs-PEG-Tf (negatively charged AuNPs with the transferrin targeting ligands) and AuNPs-PEI-FA (positively charged AuNPs with the folate-receptor targeting ligands). Both bioconjugated AuNPs demonstrated low cytotoxicity in prostate cancer cells. The attachment of the targeting ligand Tf to AuNPs successfully achieved receptor-mediated cellular uptake in PC-3 cells, a prostate cancer cell line highly expressing Tf receptors. The AuNPs-PEI-FA effectively complexed small interfering RNA (si...
http://hdl.handle.net/10468/5335
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Factors driving inequality in prostate cancer survival: a population based study
(2014)
Burns, Richéal M.; Sharp, Linda; Sullivan, Francis J.; Deady, Sandra E.; Drummond, Fran...
Factors driving inequality in prostate cancer survival: a population based study
(2014)
Burns, Richéal M.; Sharp, Linda; Sullivan, Francis J.; Deady, Sandra E.; Drummond, Frances J.; O'Neill, Ciaran
Abstract:
As cancer control strategies have become more successful, issues around survival have become increasingly important to researchers and policy makers. The aim of this study was to examine the role of a range of clinical and socio-demographic variables in explaining variations in survival after a prostate cancer diagnosis, paying particular attention to the role of healthcare provider(s) i.e. private versus public status. Data were extracted from the National Cancer Registry Ireland, for patients diagnosed with prostate cancer from 1998-2009 (N = 26,183). A series of multivariate Cox and logistic regression models were used to examine the role of healthcare provider and socio-economic status (area-based deprivation) on survival, controlling for age, stage, Gleason grade, marital status and region of residence. Survival was based on all-cause mortality. Older individuals who were treated in a private care setting were more likely to have survived than those who had not, when other fact...
http://hdl.handle.net/10468/5537
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Molecular Mechanisms of Advanced Prostate Cancer
(2018)
BRADY, LAUREN MARIE
Molecular Mechanisms of Advanced Prostate Cancer
(2018)
BRADY, LAUREN MARIE
Abstract:
Globally, prostate cancer is the fourth most common cancer type. Five year survival rates for primary localised disease are high, however these figures decrease significantly with the onset of metastasis. Obesity and inflammation have been shown to play significant roles in prostate cancer disease progression, with obesity and a high body mass index associated with increased prostate cancer-specific mortality in patients with metastatic disease. Circulating tumour cells, are cells thought to shed off the primary tumour and extravasate, forming metastatic lesions. The method by which they extravasate undetected is thought to be due in part by ?platelet cloaking? of the circulating tumour cells. A pro-inflammatory microenvironment may also aid metastatic potential and promote angiogenesis. The ExPeCT trial aimed to examine the effectiveness of a structured exercise programme on modulating circulating tumour cells, platelet cloaking, inflammatory mediators and obesity in patients with ...
http://hdl.handle.net/2262/84977
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Multidisciplinary Rehabilitation in Oesophago-gastric Cancer Surviorship
(2018)
O'NEILL, LINDA MARIE
Multidisciplinary Rehabilitation in Oesophago-gastric Cancer Surviorship
(2018)
O'NEILL, LINDA MARIE
Abstract:
As survival rates for oesophageal and gastric cancer slowly improve, there has been an emergence of a unique cohort of cancer survivors who present with multifaceted nutritional and physical needs which are amenable to rehabilitative measures. Multidisciplinary rehabilitation in oesophago-gastric cancer has been under explored and accordingly, this thesis aimed to examine i) the feasibility, ii) the efficacy of multidisciplinary rehabilitation in oesophago-gastric cancer survivorship. Study I of this thesis established the feasibility of a 12 week multidisciplinary rehabilitation consisting of supervised and homebased exercise sessions, 1:1 dietary counselling, and group education sessions. Feasibility was demonstrated by the recruitment rate, adherence rates to exercise sessions, lack of adverse events, and positive improvements in cardiorespiratory fitness (VO2max), physical performance (six minute walk test), and global health related quality of life (HRQOL). Importantly, body...
http://hdl.handle.net/2262/85000
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Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1.
(2018)
Lucantoni, Federico; Düssmann, Heiko; Prehn, Jochen HM
Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1.
(2018)
Lucantoni, Federico; Düssmann, Heiko; Prehn, Jochen HM
Abstract:
<p>The original article is available at<a href="https://www.frontiersin.org"> www.frontiersin.org</a></p>
<p>Breast cancer cells have different requirements on metabolic pathways in order to sustain their growth. Triple negative breast cancer (TNBC), an aggressive breast cancer subtype relies mainly on glycolysis, while estrogen receptor positive (ER+) breast cancer cells possess higher mitochondrial oxidative phosphorylation (OXPHOS) levels. However, breast cancer cells generally employ both pathways to sustain their metabolic needs and to compete with the surrounding environment. In this study, we demonstrate that the mitochondrial fission inhibitor MDIVI-1 alters mitochondrial bioenergetics, at concentrations that do not affect mitochondrial morphology. We show that this effect is accompanied by an increase in glycolysis consumption. Dual targeting of glycolysis with 2-deoxy-D-glucose (2DG) and mitochondrial bioenergetics with MDIVI-1 r...
https://epubs.rcsi.ie/physiolart/151
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Standards for the management of cancer-related pain across Europe. A position paper from the EFIC Task Force on Cancer Pain
(2018)
Bennett, Michael I.; Eisenberg, Elon; Ahmedzai, Sam H.; Bhaskar, Arun; O'Brien, To...
Standards for the management of cancer-related pain across Europe. A position paper from the EFIC Task Force on Cancer Pain
(2018)
Bennett, Michael I.; Eisenberg, Elon; Ahmedzai, Sam H.; Bhaskar, Arun; O'Brien, Tony; Mercadante, Sebastiano; Škvarč, Nevenka Krčevski; Vissers, Kris; Wirz, Stefan; Wells, Chris; Morlion, Bart
Abstract:
Background and Objective: Pain is a common symptom in patients that survive cancer and in those that live with progressive advanced disease. Evidence from meta‐analyses suggests that pain remains poorly controlled for a large proportion of patients; barriers to good management include poor assessment of pain, inadequate support for patient self‐management, and late or inadequate access to strong opioid analgesia in those with advanced disease. Methods: The European Pain Federation (EFIC) established a Task Force in 2017 which convened a European group of experts, drawn from a diverse range of relevant clinical disciplines, to prepare a position paper on appropriate standards for management of cancer‐related pain. The expert panel reviewed the available literature and made recommendations using the GRADE system to combine quality of evidence with strength of recommendation. The panel took into account the desirable and undesirable effects of the management recommendation, including t...
http://hdl.handle.net/10468/7241
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Evaluate the effectiveness and sustainability of OptiMal as a self-management intervention for cancer survivors
(2019)
BOLAND, LAUREN
Evaluate the effectiveness and sustainability of OptiMal as a self-management intervention for cancer survivors
(2019)
BOLAND, LAUREN
Abstract:
Introduction: There are over 150,000 cancer survivors in Ireland and survival rates are continuing to increase. Cancer survivors experience continuing symptoms such as pain, fatigue, cognitive difficulties, anxiety and depression post-treatment resulting in social isolation and decreased activity participation. Self-management interventions are recommended for cancer survivors as they can help individuals identify and manage these continuing symptoms. OptiMal is a six-week, self-management intervention originally designed for individuals with multimorbidity. The aim of this research is to evaluate OptiMal's effectiveness and sustainability as a self-management intervention for cancer survivors. Methodology: Three studies were undertaken as part of this research. Study I included a systematic review undertaken to examine the type, content and the impact of self-management interventions for cancer survivors. Study II included a mixed methods study to determine the effectiveness a...
http://hdl.handle.net/2262/86086
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IL-1 family members in cancer; two sides to every story
(2019)
Baker, Kevin J.; Houston, Aileen M.; Brint, Elizabeth K.
IL-1 family members in cancer; two sides to every story
(2019)
Baker, Kevin J.; Houston, Aileen M.; Brint, Elizabeth K.
Abstract:
The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti-inflammatory activity (IL-37, IL-38). These cytokines are known to play a key role in modulating both the innate and adaptive immunes response, with dysregulation linked to a variety of autoimmune and inflammatory diseases. Given the increasing appreciation of the link between inflammation and cancer, the role of several members of this family in the pathogenesis of cancer has been extensively investigated. In this review, we highlight both the pro- and anti-tumorigenic effects identified for almost all members of this family, and explore potential underlying mechanisms accounting for these divergent effects. Such dual functions need to be carefully assessed when developing therapeutic intervention strategies targeting these cytokines in cancer.
http://hdl.handle.net/10468/8454
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Systemic chemokine levels in breast cancer patients and their relationship with circulating menstrual hormones
(2019)
Potter, Shirley M.; Dwyer, Róisín M.; Curran, Catherine E.; Hennessy, Emer; Harrington,...
Systemic chemokine levels in breast cancer patients and their relationship with circulating menstrual hormones
(2019)
Potter, Shirley M.; Dwyer, Róisín M.; Curran, Catherine E.; Hennessy, Emer; Harrington, Kate A.; Griffin, Damian G.; Kerin, Michael J.
Abstract:
Introduction The chemokines Stromal Cell-Derived Factor-1 alpha (SDF-1 alpha/CXCL12) and Monocyte Chemotactic Protein-1 (MCP-1/CCL2) have been implicated in breast cancer progression. We recently reported elevated systemic MCP-1 in breast cancer patients. This study investigated circulating levels of SDF-1 alpha in breast cancer patients, and addressed potential hormonal regulation of these two potent chemokines. Methods SDF-1 alpha levels were determined by ELISA in 114 breast cancer patients and 85 controls, and correlated with clinical data. Blood samples were collected from 36 healthy premenopausal volunteers weekly for four weeks to measure Luteinising Hormone (LH), Follicular Stimulating Hormone (FSH), Oestradiol and Progesterone using a Bayer ADVIA(A (R)) Centaur Immunoassay system, in parallel with SDF-1 alpha and MCP-1. CXCL12 expression was determined using RQ-PCR in primary tumour stromal cells (n = 16) harvested at surgery. Results Plasma SDF-1 alpha was significantly hi...
http://hdl.handle.net/10379/15388
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Mode of prostate cancer detection is associated with the psychological wellbeing of survivors: results from the PiCTure study
(2015)
Drummond, Frances J.; O'Leary, Eamonn; Gavin, Anna T.; Kinnear, Heather; Linda, Sharp
Mode of prostate cancer detection is associated with the psychological wellbeing of survivors: results from the PiCTure study
(2015)
Drummond, Frances J.; O'Leary, Eamonn; Gavin, Anna T.; Kinnear, Heather; Linda, Sharp
Abstract:
Purpose: Many men with prostate cancer are asymptomatic, diagnosed following prostate specific antigen (PSA) testing. We investigate whether mode of detection, i.e. ‘PSA detected’ or ‘clinically detected’, was associated with psychological wellbeing among prostate cancer survivors. Methods: A cross-sectional postal questionnaire was administered in 2012 to 6559 prostate cancer (ICD10 C61) survivors up to 18 years post-diagnosis, identified through population-based cancer registries in Ireland. Psychological wellbeing was assessed using the Depression Anxiety Stress Scale-21. Logistic regression was used to investigate associations between mode of detection and depression, anxiety and stress, adjusting for socio-demographic and clinical confounders. Results: The response rate was 54 % (3348/6262). Fifty-nine percent of survivors were diagnosed with asymptomatic PSA-tested disease. Prevalence of depression (13.8 vs 20.7 %; p < 0.001), anxiety (13.6 vs 20.9 %; p < 0.001) and stre...
http://hdl.handle.net/10468/8881
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The microbiota of breast tissue and its association with breast cancer
(2016)
Urbaniak, Camilla; Gloor, Gregory B.; Brackstone, Muriel; Scott, Leslie; Tangney, Mark;...
The microbiota of breast tissue and its association with breast cancer
(2016)
Urbaniak, Camilla; Gloor, Gregory B.; Brackstone, Muriel; Scott, Leslie; Tangney, Mark; Reid, Gregor
Abstract:
In the United States, 1 in 8 women will be diagnosed with breast cancer in her lifetime. Along with genetics, the environment contributes to disease development, but what these exact environmental factors are remains unknown. We have previously shown that breast tissue is not sterile but contains a diverse population of bacteria. We thus believe that the host's local microbiome could be modulating the risk of breast cancer development. Using 16S rRNA amplicon sequencing, we show that bacterial profiles differ between normal adjacent tissue from women with breast cancer and tissue from healthy controls. Women with breast cancer had higher relative abundances of Bacillus, Enterobacteriaceae and Staphylococcus. Escherichia coli (a member of the Enterobacteriaceae family) and Staphylococcus epidermidis, isolated from breast cancer patients, were shown to induce DNA double-stranded breaks in HeLa cells using the histone-2AX (H2AX) phosphorylation (γ-H2AX) assay. We also found that m...
http://hdl.handle.net/10468/8949
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Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL.
(2018)
O'Driscoll, Lorraine; Eustace, Alex J.; Conlon, Neil T.; McDermott, Martina S.J.; ...
Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL.
(2018)
O'Driscoll, Lorraine; Eustace, Alex J.; Conlon, Neil T.; McDermott, Martina S.J.; Browne, Brigid C.; O'Leary, Patrick; Holmes, Frankie A.; Espina, Virginia; Liotta, Lance A.; O'Shaughnessy, Joyce; Gallagher, Clair; Rani, Sweta; Madden, Stephen F.; O'Brien, Neil A.; Ginther, Charles; Slamon, Dennis; Walsh, Naomi; Gallagher, William M.; Zagozdzon, Radoslaw; Watson, William R.
Abstract:
Background: Lapatinib has clinical efficacy in the treatment of trastuzumab-refractory HER2-positive breast cancer. However, a significant proportion of patients develop progressive disease due to acquired resistance to the drug. Induction of apoptotic cell death is a key mechanism of action of lapatinib in HER2-positive breast cancer cells. Methods: We examined alterations in regulation of the intrinsic and extrinsic apoptosis pathways in cell line models of acquired lapatinib resistance both in vitro and in patient samples from the NCT01485926 clinical trial, and investigated potential strategies to exploit alterations in apoptosis signalling to overcome lapatinib resistance in HER2-positive breast cancer. Results: In this study, we examined two cell lines models of acquired lapatinib resistance (SKBR3-L and HCC1954-L) and showed that lapatinib does not induce apoptosis in these cells. We identified alterations in members of the BCL-2 family of proteins, in particular MCL-1 and BA...
http://hdl.handle.net/2262/91091
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Cancer in young people in the north of England, 1968-85: analysis by census wards
(1993)
Craft, Alan; Parker, L.; Openshaw, S.; Charlton, Martin; Newell, J.N.; Birch, J.M.
Cancer in young people in the north of England, 1968-85: analysis by census wards
(1993)
Craft, Alan; Parker, L.; Openshaw, S.; Charlton, Martin; Newell, J.N.; Birch, J.M.
Abstract:
To determine whether the seeming excess of childhood leukaemia and lymphoma identified in Seascale, Cumbria, UK, remains unusual when put into a wider context. Analysis of cancer incidence by geographical area. The north of England including the Northern and North Western Regional Health Authority regions and the Southport and South Sefton districts of the Mersey Regional Health Authority. Altogether 6686 cases of malignant disease in people under 25 years old. Cases of cancer diagnosed before their 25th birthday between January 1968 and December 1985 identified from three regional cancer registries were allocated to a census ward on the basis of 'usual place of residence'. Population data were derived from the 1971 and 1981 censuses, and the cancer incidence was calculated for each ward. Of the 6686 cases, there were 1035 cases of acute lymphoblastic leukaemia and 361 of non-Hodgkins lymphoma. Wards were ranked by cancer incidence and Poisson probability, using different ...
http://mural.maynoothuniversity.ie/6105/
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Resistance to HER2-targeted anti-cancer drugs is associated with immune evasion in cancer cells and their derived extracellular vesicles
(2017)
O'Driscoll, Lorraine; Martinez, Vanesa G.; O'Neill, Sadhbh; Salimu, Josephine...
Resistance to HER2-targeted anti-cancer drugs is associated with immune evasion in cancer cells and their derived extracellular vesicles
(2017)
O'Driscoll, Lorraine; Martinez, Vanesa G.; O'Neill, Sadhbh; Salimu, Josephine; Breslin, Susan; Clayton, Aled; Crown, John
Abstract:
Neuromedin U (NmU) -a neuropeptide belonging to the neuromedin family? plays a substantial role in HER2-positive breast cancer, correlating with increased aggressiveness, resistance to HER2-targeted therapies and overall significantly poorer outcome for patients. However, the mechanism through which it exerts these effects remains unclear. To elucidate this, initially we used HER2-positive breast cancer cells stably over-expressing NmU. These cells and their released extracellular vesicles (EVs) had increased amounts of the immunosuppressive cytokine TGF?1 and the lymphocyte activation inhibitor PD-L1. Furthermore, these cells also showed enhanced resistance to antibody-dependent cell cytotoxicity (ADCC) mediated by trastuzumab, indicating a role of NmU in enhancing immune evasion. All these features were also found in HER2-targeted drug-resistant cells which we previously found to express higher levels of NmU than their drug-sensitive counterparts. Interestingly, EVs from drug-resi...
http://hdl.handle.net/2262/91792
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Financial hardship associated with colorectal cancer survivorship: The role of asset depletion and debt accumulation
(2018)
Hanly, Paul; Maguire, Rebecca; O Ceilleachair, Alan; Sharp, Linda
Financial hardship associated with colorectal cancer survivorship: The role of asset depletion and debt accumulation
(2018)
Hanly, Paul; Maguire, Rebecca; O Ceilleachair, Alan; Sharp, Linda
Abstract:
Objective: To estimate the prevalence of financial objective stress and subjective strain among colorectal cancer survivors and assess associated financial coping factors in Ireland, which has a mixed public‐private health care system. Methods: Colorectal cancer survivors were identified from the National Cancer Registry, and a sample of 496 respondents were included in the analysis. A postal survey collected information on survivor demographics, socio‐economic background, medical characteristics, cancer‐related financial hardship, debt accumulation, and asset depletion. Cancer‐related financial objective stress and subjective strain were used as dependent variables in logistic regression analysis. Results: Approximately 2 in 5 survivors experienced objective stress (40.9%) or subjective strain (39.4%). Depletion of savings (49.1%) was the most prevalent form of financial coping strategy. Factors significantly associated with increased objective stress were having a stoma (OR = 2....
http://mural.maynoothuniversity.ie/12624/
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Long non‐coding RNA AGER‐1 functionally upregulates the innate immunity gene AGER and approximates its anti‐tumor effect in lung cancer
(2018)
Pan, Zihua; Nie, Wenjing; Miggin, Sinead; Qiu, Fuman; Cao, Yi; Chen, Jinbin; Yang, Biny...
Long non‐coding RNA AGER‐1 functionally upregulates the innate immunity gene AGER and approximates its anti‐tumor effect in lung cancer
(2018)
Pan, Zihua; Nie, Wenjing; Miggin, Sinead; Qiu, Fuman; Cao, Yi; Chen, Jinbin; Yang, Binyao; Zhou, Yifeng; Lu, Jiachun; Yang, Lei
Abstract:
Little is known about long non‐coding RNA (lncRNA) related to innate immunity in lung cancer. The advanced glycosylation end‐product specific receptor (AGER) belongs to the immunoglobulin superfamily, and currently, is the only innate immune pattern‐recognition receptor whose abnormal expression has been detected in lung cancer. We aimed to explore the lncRNA that is related to AGER and test its effect on lung carcinogenesis. We selected one lncRNA whose chromosome location is in close proximity to AGER namely lnc‐AGER‐1 (defined as lncAGER). The expression of lncAGER was tested in 276 pairs of lung cancer tissues and adjacent lung normal tissues, and its correlation with lung cancer clinical progress was analyzed. A series of assays were further used to assess the biological function of lncAGER on lung cancer development, tumor immunity and autophagy. LncAGER expression was moderately correlated with AGER expression (r = 0.360, P = 2.15 × 10−18) underlying a mechanism that lncAGER ...
http://mural.maynoothuniversity.ie/11668/
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Analysis of acute-phase proteins, AHSG, C3, CLI, HP and SAA, reveals distinctive expression patterns associated with breast, colorectal and lung cancer
(2012)
Dowling, Paul; Clarke, Colin; Hennessy, Kim; Torralbo-Lopez, Beatriz; Ballot, Jo; Crown...
Analysis of acute-phase proteins, AHSG, C3, CLI, HP and SAA, reveals distinctive expression patterns associated with breast, colorectal and lung cancer
(2012)
Dowling, Paul; Clarke, Colin; Hennessy, Kim; Torralbo-Lopez, Beatriz; Ballot, Jo; Crown, John; Kiernan, Ingrid; O'Byrne, Kenneth J.; Kennedy, M. John; Lynch, Vincent; Clynes, Martin
Abstract:
Early detection, clinical management and disease recurrence monitoring are critical areas in cancer treatment in which specific biomarker panels are likely to be very important in each of these key areas. We have previously demonstrated that levels of alpha-2-heremans-schmid-glycoprotein (AHSG), complement component C3 (C3), clusterin (CLI), haptoglobin (HP) and serum amyloid A (SAA) are significantly altered in serum from patients with squamous cell carcinoma of the lung. Here, we report the abundance levels for these proteins in serum samples from patients with advanced breast cancer, colorectal cancer (CRC) and lung cancer compared to healthy controls (age and gender matched) using commercially available enzyme-linked immunosorbent assay kits. Logistic regression (LR) models were fitted to the resulting data, and the classification ability of the proteins was evaluated using receiver-operating characteristic curve and leave-one-out cross-validation (LOOCV). The most accurate indi...
http://mural.maynoothuniversity.ie/6868/
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Applications of Raman micro-spectroscopy for cancer diagnostics
(2016)
Kerr, Laura
Applications of Raman micro-spectroscopy for cancer diagnostics
(2016)
Kerr, Laura
Abstract:
Bladder cancer has the highest recurrence rate of any cancer, and as with most solid organ malignancies, early diagnosis, detection, and treatment are imperative for good clinical outcomes. Cystoscopy is the cornerstone of bladder diagnostics for real-time visualization of the bladder mucosa. However, it is an uncomfortable, invasive procedure, and is not without significant risk and potential complications for the patient. Urine cytology is currently the only non-invasive diagnostic tool available for the diagnosis of bladder cancer; this method is highly sensitive for high grade tumours, but has low sensitivity for low grade tumours, which accounts for the majority of cases. Therefore, there exists a clinical need to develop and integrate a non-invasive, accurate technique to assist in the diagnosis of bladder cancer. The combination of Raman micro-spectroscopy and voided urine cytology may provide an ideal platform to replace cystoscopy for bladder cancer diagnostics. By recordin...
http://mural.maynoothuniversity.ie/7914/
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Investigation into the Pathophysiology and the Objective Neurophysiological Measurement of Cancer-Related Fatigue in a Pre-Treatment Cancer Cohort
(2020)
O'HIGGINS, CIARA MARIE
Investigation into the Pathophysiology and the Objective Neurophysiological Measurement of Cancer-Related Fatigue in a Pre-Treatment Cancer Cohort
(2020)
O'HIGGINS, CIARA MARIE
Abstract:
Cancer-related fatigue (CRF) is one of the most common, debilitating, highly prevalent and unrelenting symptom experienced by patients through all stages of the cancer trajectory and often into survivorship (Berger et al., 2015a; Barsevick et al., 2010). Two factors, central and peripheral, can contribute to fatigue in CRF sufferers. Central fatigue involves difficulty in initiating or sustaining voluntary activities (Davis and Walsh, 2010; Gandevia, 2001), due to challenges with self-motivation, perceived demand and internal biochemical cues, without demonstrable cognitive failure or motor weakness (Davis and Walsh, 2010; Finsterer and Mahjoub, 2014). Peripheral fatigue is caused by failure of either muscle excitation-contraction mechanisms or metabolic changes within the muscle which generally manifest at the affected muscle site and can be described as a progressive loss of power or any exercise induced reduction in the ability to exert muscle force or power. (Davis and Wals...
http://hdl.handle.net/2262/92573
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Serum NETosis expression and recurrence risk after regional or volatile anaesthesia during breast cancer surgery: A pilot, prospective, randomised single-blind clinical trial
(2020)
Aghamelu, Onyinye; Buggy, Padraig; Smith, Genevieve; Inzitari, Rosanna; Wall, Tom P.; B...
Serum NETosis expression and recurrence risk after regional or volatile anaesthesia during breast cancer surgery: A pilot, prospective, randomised single-blind clinical trial
(2020)
Aghamelu, Onyinye; Buggy, Padraig; Smith, Genevieve; Inzitari, Rosanna; Wall, Tom P.; Buggy, Donal P.
Abstract:
Background: Some experimental and retrospective clinical studies signal an association between certain anaesthetic techniques and tumour metastasis following breast cancer surgery. Neutrophil Extracellular Trapping (NETosis) is an immunological process, whereby neutrophils engulf tumour antigen then degranulate, leaving a serologic marker. NETosis expression among breast cancer patients is associated with an increased risk of metastasis. We investigated the effect of two distinct anaesthetic techniques on the expression of NETosis in women who underwent potentially curative breast cancer surgery. Methods: In a parallel-group, randomised controlled trial, a subset of women (n = 40) undergoing breast cancer resection surgery, who were partaking in a larger trial (NCT00418457), were randomly assigned to receive volatile general anaesthesia (GA) or propofol GA combined with paravertebral regional anaesthesia (PPA) for their surgery. Serum was taken and stored before and 24 hours post-op...
http://hdl.handle.net/10468/10842
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The role of eHealth to promote physical activity in people with cancer.
(2020)
HABERLIN, CIARAN
The role of eHealth to promote physical activity in people with cancer.
(2020)
HABERLIN, CIARAN
Abstract:
The role of eHealth to promote physical activity in people with cancer. Ciar?n Haberlin BSc (Physiotherapy), P.Grad. Cert (Clinical Exercise) Background Exercise and physical activity (PA) are established and effective treatment options for various side effects of cancer treatments such as surgery, chemotherapy and radiotherapy. However, PA levels in cancer survivors remain low. The advent of eHealth brings new opportunities to influence healthy behaviours, using interactive and novel approaches. Influencing PA behaviours in people with cancer presents a potential application of this. The aim of this thesis was to explore and evaluate the feasibility and preliminary efficacy of an intervention, using eHealth, for increasing PA in cancer survivors. Methods A systematic review, cross-sectional questionnaire-based study, qualitative focus group study and a single-arm pre?post feasibility study were conducted in this thesis. The systematic review that was conducted as part of this th...
http://hdl.handle.net/2262/94450
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Automatic segmentation of skin cancer images using adaptive color clustering
(2006)
Ilea, Dana E.; Whelan, Paul F.
Automatic segmentation of skin cancer images using adaptive color clustering
(2006)
Ilea, Dana E.; Whelan, Paul F.
Abstract:
This paper presents the development of an adaptive image segmentation algorithm designed for the identification of the skin cancer and pigmented lesions in dermoscopy images. The key component of the developed algorithm is the Adaptive Spatial K-Means (A-SKM) clustering technique that is applied to extract the color features from skin cancer images. Adaptive-SKM is a novel technique that includes the primary features that describe the color smoothness and texture complexity in the process of pixel assignment. The A-SKM has been included in the development of a flexible color-texture image segmentation scheme and the experimental data indicates that the developed algorithm is able to produce accurate segmentation when applied to a large number of skin cancer (melanoma) images.
http://doras.dcu.ie/4660/
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