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Displaying Results 226 - 250 of 2482 on page 10 of 100

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SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population. (2013)

ZGAGA, LINA

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miR-34a is an intracellular and exosomal predictive biomarker for response to docetaxel with clinical relevance to prostate cancer progression. (2014)

CORCORAN, CLAIRE; O'DRISCOLL, LORRAINE

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Generation and characterisation of Cisplatin-resistant non-small cell lung cancer cell lines displaying a stem-like signature. (2013)

BARR, MARTIN; O'LEARY, JOHN; GRAY, STEVEN

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Microcalcifications in breast cancer: novel insights into the molecular mechanism and functional consequence of mammary mineralisation. (2012)

Cox, Rachel F; Hernandez-Santana, Aron; Ramdass, S; McMahon, Gillian; Harmey, Judith H;...

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Development and validation of a clinical prediction rule to identify suspected breast cancer: a prospective cohort study. (2014)

Galvin, Rose; Joyce, Doireann; Downey, Eithne; Boland, Fiona; Fahey, Tom; Hill, Arnold DK

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Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer. (2009)

Doherty, Glen A; Byrne, Sinead M; Molloy, Eamonn S; Malhotra, Vikrum; Austin, Sandra C;...

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Comparative evaluation of novel biodegradable nanoparticles for the drug targeting to breast cancer cells. (2013)

Mattu, Clara; Pabari, Ritesh; Boffito, M; Sartori, S; Ciardelli, G; Ramtoola, Zeibun

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High levels of X-linked Inhibitor-of-Apoptosis Protein (XIAP) are indicative of radio chemotherapy resistance in rectal cancer. (2015)

Flanagan, Lorna; Kehoe, Joan; Fay, J; Bacon, Orna; Lindner, Andreas U; Kay, Elaine W; D...

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miR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity. (2015)

O'DRISCOLL, LORRAINE

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MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice. (2014)

FALLON, PADRAIC; CORR, SINEAD

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Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective (2009)

World Cancer Research Fund / American Institute for Cancer Research

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A role of autophagy in PTP4A3-driven cancer progression. (2014)

MURRAY, JAMES

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Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. (2014)

ZGAGA, LINA

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Cancer inequalities in South Central Strategic Health Authority (2009)

Oxford Cancer Intelligence Unit

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The use of LC-MS to identify differentially expressed proteins in docetaxel-resistant prostate cancer cell lines (2012)

O'Connell, Kathleen; Prencipe, Maria; O'Neill, Amanda; Corcoran, Claire; Rani...

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7B7: a novel antibody directed against the Ku70/Ku80 heterodimer blocks invasion in pancreatic and lung cancer cells (2014)

O'Sullivan, Dermot; Henry, Michael; Joyce, Helena; Walsh, Naomi; Mc Auley, Edel; D...

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Long-term workforce participation patterns following head and neck cancer (2014)

Pearce, Alison; Timmons, Aileen; O’Sullivan, Eleanor; Gallagher, Pamela; Gooberman-Hill...

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Cancer-related insomnia (2014)

WALSH, THOMAS

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Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-μ. In Vitro Synergy Quantification of Pifithrin-μ Combined with Pt Drugs in Prostate and Colorectal Cancer Cells. (2016)

McKeon, Aoife M; Egan, Alan; Chandanshive, Jay; McMahon, Helena; Griffith, Darren M

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Aldehyde dehydrogenase 1A1 and gelsolin identified as novel invasion-modulating factors in conditioned medium of pancreatic cancer cells (2008)

Walsh, Naomi; Dowling, Paul; O'Donovan, Norma; Henry, Michael; Meleady, Paula; Cly...

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Development of a novel probe integrated with a micro-structured impedance sensor for the detection of breast cancer (2016)

Savage, Niall Thomas Patrick

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A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer. (2017)

Salvucci, Manuela; Würstle, Maximilian L; Morgan, Clare; Curry, Sarah; Cremona, Mattia;...

A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer. (2017)

Salvucci, Manuela; Würstle, Maximilian L; Morgan, Clare; Curry, Sarah; Cremona, Mattia; Lindner, Andreas U; Bacon, Orna; Resler, Alexa J; Murphy, Áine C; O'Byrne, Robert; Flanagan, Lorna; Dasgupta, Sonali; Rice, Nadege; Pilati, Camilla; Zink, Elisabeth; Schöller, Lisa M; Toomey, Sinead; Lawler, Mark; Johnston, Patrick G; Wilson, Richard

Abstract:

<p>The original article is available at http://clincancerres.aacrjournals.org</p>
<p>Purpose: Apoptosis is essential for chemotherapy responses. In this discovery and validation study, we evaluated the suitability of a mathematical model of apoptosis execution (APOPTO-CELL) as a stand-alone signature and as a constituent of further refined prognostic stratification tools.Experimental Design: Apoptosis competency of primary tumor samples from patients with stage III colorectal cancer (n = 120) was calculated by APOPTO-CELL from measured protein concentrations of Procaspase-3, Procaspase-9, SMAC, and XIAP. An enriched APOPTO-CELL signature (APOPTO-CELL-PC3) was synthesized to capture apoptosome-independent effects of Caspase-3. Furthermore, a machine learning Random Forest approach was applied to APOPTO-CELL-PC3 and available molecular and clinicopathologic data to identify a further enhanced signature. Association of the signature with prognosis was evaluated in...