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Current Search:
'Cancer' in all fields;
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Displaying Results 251 - 275 of 3617 on page 11 of 145
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Implementing Ireland’s first national population-based colorectal cancer screening programme
(2010)
National Cancer Screening Service (NCSS)
Implementing Ireland’s first national population-based colorectal cancer screening programme
(2010)
National Cancer Screening Service (NCSS)
http://hdl.handle.net/10147/107613
Marked
Mark
All Ireland cancer statistics 1994-96 a joint report on incidence and mortality on the island of Ireland
(2001)
National Cancer Registry Ireland; Northern Ireland Cancer Registry
All Ireland cancer statistics 1994-96 a joint report on incidence and mortality on the island of Ireland
(2001)
National Cancer Registry Ireland; Northern Ireland Cancer Registry
http://hdl.handle.net/10147/77436
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Mark
An oral cancer screening study of high risk individuals
(2008)
O'Sullivan, Eleanor
An oral cancer screening study of high risk individuals
(2008)
O'Sullivan, Eleanor
Abstract:
This study indicates that an Oral Cancer Screening programme targeted at high risk 1nd1viduals 1s feasible, acceptable and effect1ve. In a senes of 210 residents, 60% of whom were outside the ideal target age for Head and Neck Cancer, a total of 84 mucosal abnormalities were detected. Thirteen of the 28 Extra-Oral Lesions/ENT symptoms and 19 of the 56 Intra-Oral lesions were potentially significant. Despite the poor compliance rate for further investigation, two premalignant les1ons were detected in the mam study group, a detect1on rate of 0.9%. Furthermore, a malignant Basal Cell Cancer, which had 1nvaded mto deep dermis. was detected in the sub-group excluded from the main study. If these residents are included, the detection rate for malignant and premalignant lesions rises to 1.3% (3/220).
http://hdl.handle.net/10147/240878
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Biological evaluation of N-Ferrocenyl amino acid and dipeptide ester derivatives as potential anti-cancer agents and investigation into their mode of action in preparation for in vivo evaluation.
(2014)
Murphy, James
Biological evaluation of N-Ferrocenyl amino acid and dipeptide ester derivatives as potential anti-cancer agents and investigation into their mode of action in preparation for in vivo evaluation.
(2014)
Murphy, James
Abstract:
The aim of this research thesis was to explore the structure-activity relationship (SAR) of ferrocenyl-peptide bioconjugates and to explore methods by which these compounds exert their anti-proliferative on cancer cells. Furthermore, the applicability across different cell types including cancer cells which have acquired resistance to chemotherapeutics and non-cancerous cells was investigated. Finally, we attempted to overcome the insolubility of the ferrocene compounds in a liquid which is suitable for delivery in vivo. We evaluated a panel of novel ferrocenyl-peptide bioconjugates for their anti-cancer potential in lung and melanoma cells. Utilizing structure-activity relationship (SAR) studies we found the anti-proliferative activity of the compounds tested varies greatly depending on the configuration of the compound. Two of the most active compounds N-(6-ferrocenyl-2-naphthoyl)-glycine-glycine ethyl and methyl ester showed IC50 values in the nanomolar range. Cisplatin was used ...
http://doras.dcu.ie/19786/
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Androgen receptor signaling in prostate cancer development and progression
(2011)
LONERGAN, PETER EOIN
Androgen receptor signaling in prostate cancer development and progression
(2011)
LONERGAN, PETER EOIN
Abstract:
The androgen receptor (AR) signaling axis plays a critical role in the development, function and homeostasis of the prostate. The classical action of AR is to regulate gene transcriptional processes via AR nuclear translocation, binding to androgen response elements on target genes and recruitment of, or crosstalk with, transcription factors. Prostate cancer initiation and progression is also uniquely dependent on AR. Androgen deprivation therapy remains the standard of care for treatment of advanced prostate cancer. Despite an initial favorable response, almost all patients invariably progress to a more aggressive, castrate-resistant phenotype. Considerable evidence now supports the concept that development of castrate-resistant prostate cancer (CRPC) is causally related to continued transactivation of AR. Understanding the critical events and complexities of AR signaling in the progression to CRPC is essential in developing successful future therapies. This review provides a synop...
http://hdl.handle.net/2262/60169
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Transferrin conjugation does not increase the efficiency of liposomal Foscan during in vitro photodynamic therapy of oesophageal cancer
(2013)
EHRHARDT, CARSTEN; SENGE, MATHIAS; PASZKO, EDYTA
Transferrin conjugation does not increase the efficiency of liposomal Foscan during in vitro photodynamic therapy of oesophageal cancer
(2013)
EHRHARDT, CARSTEN; SENGE, MATHIAS; PASZKO, EDYTA
Abstract:
Photodynamic therapy (PDT) is based on the delivery of photocytotoxic agents to a target tissue, followed by irradiation. In order to increase the efficiency of PDT in oesophageal cancer therapy, polyethylene glycol (PEG)-grafted, transferrin (Tf)-conjugated liposome formulations of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (Foscan), a second-generation photosensitiser, were prepared. Expression of transferrin receptors (CD71) in the oesophageal cancer cell line, OE21, was confirmed by immunoblot and confocal laser scanning microscopy. The anti-proliferative effect of Foscan liposomes was evaluated and compared with plain formulations (i.e., without Tf) as well as with free drug. In addition, the intracellular accumulation was studied using high content analysis. Surprisingly, delivering Foscan by transferrin-conjugated PEG-liposomes to oesophageal cancer cells did not improve the photocytotoxicity or the intracellular accumulation of Foscan when compared to unmodified liposomes or i...
http://hdl.handle.net/2262/67518
Marked
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Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells.
(2002)
PIDGEON, GRAHAM
Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells.
(2002)
PIDGEON, GRAHAM
Abstract:
Extensive studies have implicated the role of dietary fatty acids in prostatecancer progression. Platelet-type 12-Lipoxygenase (12-LOX) has beenshown to regulate growth, metastasis, and angiogenesis of prostate cancer. The effect of two 12-LOX inhibitors, Baicalein and N-benzyl-N-hydroxy-5-phenylpentamide (BHPP), on the mechanisms controlling cell cycle progression and apoptosis were examined in two prostate cancer cell lines, PC3 and DU-145. Treatment with Baicalein or BHPP resulted in a dose-dependent decrease in cell proliferation, as measured by BrdUrd incorporation. This growth arrest was shown to be because of cell cycle inhibition at G0/G1, and was associated with suppression of cyclin D1 and D3 protein levels. PC3 cells also showed a strong decrease in phosphorylated retinoblastoma (pRB) protein, whereas the other retinoblastoma-associated proteins, p107 and p130, were inhibited in DU-145 cells. Treatment with 12-hydroxyeicosatetraenoic acid in the presence of Baicalein bloc...
http://hdl.handle.net/2262/36608
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Mark
The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.
(2009)
HUGHES, DAVID JOHN
The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.
(2009)
HUGHES, DAVID JOHN
Abstract:
The TP53 pathway, in which TP53 and its negative regulator MDM2 are the central elements, has an important role in carcinogenesis, particularly in BRCA1- and BRCA2-mediated carcinogenesis. A single nucleotide polymorphism (SNP) in the promoter region of MDM2 (309T>G, rs2279744) and a coding SNP of TP53 (Arg72Pro, rs1042522) have been shown to be of functional significance. METHODS: To investigate whether these SNPs modify breast cancer risk for BRCA1 and BRCA2 mutation carriers, we pooled genotype data on the TP53 Arg72Pro SNP in 7011 mutation carriers and on the MDM2 309T>G SNP in 2222 mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Data were analysed using a Cox proportional hazards model within a retrospective likelihood framework. RESULTS: No association was found between these SNPs and breast cancer risk for BRCA1 (TP53: per-allele hazard ratio (HR)=1.01, 95% confidence interval (CI): 0.93-1.10, P(trend)=0.77; MDM2: HR=0.96, 95%CI...
http://hdl.handle.net/2262/60886
Marked
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Characterisation and manipulation of docetaxel resistant prostate cancer cell lines
(2011)
RANI, SWETA; O'DRISCOLL, LORRAINE
Characterisation and manipulation of docetaxel resistant prostate cancer cell lines
(2011)
RANI, SWETA; O'DRISCOLL, LORRAINE
Abstract:
Background: There is no effective treatment strategy for advanced castration-resistant prostate cancer. Although Docetaxel (Taxotere?) represents the most active chemotherapeutic agent it only gives a modest survival advantage with most patients eventually progressing because of inherent or acquired drug resistance. The aims of this study were to further investigate the mechanisms of resistance to Docetaxel. Three Docetaxel resistant sub-lines were generated and confirmed to be resistant to the apoptotic and anti-proliferative effects of increasing concentrations of Docetaxel. Results: The resistant DU-145 R and 22RV1 R had expression of P-glycoprotein and its inhibition with Elacridar partially and totally reversed the resistant phenotype in the two cell lines respectively, which was not seen in the PC-3 resistant sublines. Resistance was also not mediated in the PC-3 cells by cellular senescence or autophagy but multiple changes in pro- and anti-apoptotic genes and proteins were ...
http://hdl.handle.net/2262/60944
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Mark
The Role of Epigenetics in Resistance to Cisplatin Chemotherapy in Lung Cancer
(2011)
O'BYRNE, KEN; BARR, MARTIN; GRAY, STEVEN
The Role of Epigenetics in Resistance to Cisplatin Chemotherapy in Lung Cancer
(2011)
O'BYRNE, KEN; BARR, MARTIN; GRAY, STEVEN
Abstract:
Non-small cell lung cancer (NSCLC) is the most common cause of cancer related death in the world. Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to treat the disease. These agents, usually combined with drugs such as gemcitabine or pemetrexed, induce objective tumor responses in only 20?30% of patients. Aberrant epigenetic regulation of gene expression is a frequent event in NSCLC. In this article we review the emerging evidence that epigenetics and the cellular machinery involved with this type of regulation may be key elements in the development of cisplatin resistance in NSCLC.
http://hdl.handle.net/2262/55443
Marked
Mark
The role of epigenetics in resistance to cisplatin chemotherapy in lung cancer
(2011)
GRAY, STEVEN; BARR, MARTIN; O'BYRNE, KEN
The role of epigenetics in resistance to cisplatin chemotherapy in lung cancer
(2011)
GRAY, STEVEN; BARR, MARTIN; O'BYRNE, KEN
Abstract:
Non-small cell lung cancer (NSCLC) is the most common cause of cancer related death in the world. Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to treat the disease. These agents, usually combined with drugs such as gemcitabine or pemetrexed, induce objective tumor responses in only 20?30% of patients. Aberrant epigenetic regulation of gene expression is a frequent event in NSCLC. In this article we review the emerging evidence that epigenetics and the cellular machinery involved with this type of regulation may be key elements in the development of cisplatin resistance in NSCLC
http://hdl.handle.net/2262/55887
Marked
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Correlation of p16(INK4A) expression and HPV copy number with cellular FTIR spectroscopic signatures of cervical cancer cells.
(2011)
MARTIN, CARA; O'LEARY, JOHN
Correlation of p16(INK4A) expression and HPV copy number with cellular FTIR spectroscopic signatures of cervical cancer cells.
(2011)
MARTIN, CARA; O'LEARY, JOHN
Abstract:
Cervical cancer, a potentially preventable disease, has its main aetiology in infection by high risk human papillomavirus (HR-HPV). Approaches to improving cervical cancer screening and diagnostic methodologies include molecular biological analysis, targeting of biomarker proteins, but also exploration and implementation of new techniques such as vibrational spectroscopy. This study correlates the biomarker protein p16(INK4A) expression levels dependent on HPV copy number with the infrared absorption spectral signatures of the cervical cancer cell lines, HPV negative C33A, HPV-16 positive SiHa and CaSki and HPV-18 positive HeLa. Confocal fluorescence microscopy demonstrated that p16(INK4A) is expressed in all investigated cell lines in both nuclear and cytoplasmic regions, although predominantly in the cytoplasm. Flow cytometry was used to quantify the p16(INK4A) expression levels and demonstrated a correlation, albeit nonlinear, between the reported number of integrated HPV copies ...
http://hdl.handle.net/2262/61591
Marked
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Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment.
(2014)
O'NEILL, LUKE; LYSAGHT, JOANNE; CONROY, MELISSA
Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment.
(2014)
O'NEILL, LUKE; LYSAGHT, JOANNE; CONROY, MELISSA
Abstract:
The immune system has a key role to play in controlling cancer initiation and progression. T cell activation, which is central to anti-tumor immune responses, coincides with changes in cellular metabolism. Na?ve T cells predominantly require an ATP generating metabolic profile, whereas proliferating effector T cells require anabolic metabolic profiles that promote rapid growth and proliferation. Furthermore, specific T cell subsets require distinct energetic and biosynthetic pathways to match their functional requirements. The often hostile tumor microenvironment can affect T cell immune responses by altering the resulting cellular metabolism. Tailoring immune responses by manipulating cellular metabolic pathways may provide an exciting new option for cancer immunotherapy. T cell responses might also be skewed via metabolic manipulation to treat the complications of obesity-associated inflammation, which is a rapidly growing global health problem and a major risk factor for many mal...
http://hdl.handle.net/2262/70460
Marked
Mark
Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival
(2013)
MURRAY, JAMES
Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival
(2013)
MURRAY, JAMES
Abstract:
Hypoxia in the microenvironment of many solid tumours is an important determinant of malignant progression. The ISR (integrated stress response) protects cells from the ER (endoplasmic reticulum) stress caused by severe hypoxia. Likewise, autophagy is a mechanism by which cancer cells can evade hypoxic cell death. In the present paper we report that the autophagy-initiating kinase ULK1 (UNC51-like kinase 1) is a direct transcriptional target of ATF4 (activating transcription factor 4), which drives the expression of ULK1 mRNA and protein in severe hypoxia and ER stress. We demonstrate that ULK1 is required for autophagy in severe hypoxia and that ablation of ULK1 causes caspase-3/7-independent cell death. Furthermore, we report that ULK1 expression is associated with a poor prognosis in breast cancer. Collectively, the findings of the present study identify transcriptional up-regulation of ULK1 as a novel arm of the ISR, and suggest ULK1 as a potentially effective target for cancer ...
http://hdl.handle.net/2262/72159
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Using resource modelling to inform decision making and service planning: The case of colorectal cancer screening in Ireland
(2013)
WALSH, CATHAL; WALTON, CLAIR
Using resource modelling to inform decision making and service planning: The case of colorectal cancer screening in Ireland
(2013)
WALSH, CATHAL; WALTON, CLAIR
Abstract:
Background Organised colorectal cancer screening is likely to be cost-effective, but cost-effectiveness results alone may not help policy makers to make decisions about programme feasibility or service providers to plan programme delivery. For these purposes, estimates of the impact on the health services of actually introducing screening in the target population would be helpful. However, these types of analyses are rarely reported. As an illustration of such an approach, we estimated annual health service resource requirements and health outcomes over the first decade of a population-based colorectal cancer screening programme in Ireland. Methods A Markov state-transition model of colorectal neoplasia natural history was used. Three core screening scenarios were considered: (a) flexible sigmoidoscopy (FSIG) once at age 60, (b) biennial guaiac-based faecal occult blood tests (gFOBT) at 55?74 years, and (c) biennial faecal immunochemical tests (FIT) at 55?74 years. Three alternati...
http://hdl.handle.net/2262/72729
Marked
Mark
Improving outcomes for people with skin tumours including melanoma (update)
(2010)
Northern Ireland Cancer Network (NICaN)
Improving outcomes for people with skin tumours including melanoma (update)
(2010)
Northern Ireland Cancer Network (NICaN)
Abstract:
The management of low-risk basal cell carcinomas in the community.In February 2006, the National Institute for Health and Clinical Excellence (NICE) published service guidance on skin cancer, ‘Improving outcomes for people with skin tumours including melanoma’ (NICE guidance on cancer services). Many of the recommendations in this guidance were converted into peer review measures published in the ‘Manual for cancer services 2008: skin measures..
http://dx.doi.org/10.14655/4660-9908
Marked
Mark
University Research Proposal Submission Topics 2010
(2010)
Northern Ireland Cancer Network (NICaN)
University Research Proposal Submission Topics 2010
(2010)
Northern Ireland Cancer Network (NICaN)
Abstract:
Dietetics Rectal Tumours and Pressure Relief Physio and Pilates with Gynae Cancer PatientsPhysio Nordic Walking and Breast CancerNeuro RehabRelaxation and Lung Cancer Physio for a Haematology Exercise Scheme - Cancer Related Fatigue Strategies Physio Classes and Prostate CancerRehab - Malignant Spinal Cord Compression and Rehab needs Seating.
http://dx.doi.org/10.14655/4660-20234
Marked
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Developing ovarian cancer stem cell models: laying the pipeline from discovery to clinical intervention.
(2014)
O'LEARY, JOHN; GALLAGHER, MICHAEL
Developing ovarian cancer stem cell models: laying the pipeline from discovery to clinical intervention.
(2014)
O'LEARY, JOHN; GALLAGHER, MICHAEL
Abstract:
Despite decades of research, ovarian cancer is still associated with unacceptably high mortality rates, which must be addressed by novel therapeutic approaches. One avenue through which this may be achieved is targeting of tumor-initiating 'Cancer Stem Cells' (CSCs). CSCs are sufficient to generate primary and recurrent disease through extensive rounds of asymmetric division, which maintain the CSC pool while producing the tissues that form the bulk of the tumor. CSCs thrive in the harsh tumor niche, are generally refractory to therapeutic intervention and closely-linked to the Epithelial-Mesenchymal Transition process, which facilitates invasion and metastasis. While it is well-accepted that CSC-targeting must be assessed as a novel therapeutic avenue, few ovarian CSC models have been developed due to perceived and actual difficulties associated with the process of 'CSC Discovery'. In this article we review contemporary approaches to CSC Discovery and argue that...
http://hdl.handle.net/2262/74153
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Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer.
(2015)
Johnstone, Cameron N; Smith, Yvonne E; Cao, Yuan; Burrows, Allan D; Cross, Ryan SN; Lin...
Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer.
(2015)
Johnstone, Cameron N; Smith, Yvonne E; Cao, Yuan; Burrows, Allan D; Cross, Ryan SN; Ling, Xiawei; Redvers, Richard P; Doherty, Judy P; Eckhardt, Bedrich L; Natoli, Anthony L; Restall, Christina M; Lucas, Erin; Pearson, Helen B; Deb, Siddhartha; Britt, Kara L; Rizzitelli, Alexandra; Li, Jason; Harmey, Judith H; Pouliot, Normand; Anderson, Robin L
Abstract:
<p>The original article is available at <a href="http://www.biologists.com">www.biologists.com</a></p>
<p>The translation of basic research into improved therapies for breast cancer patients requires relevant preclinical models that incorporate spontaneous metastasis. We have completed a functional and molecular characterisation of a new isogenic C57BL/6 mouse model of breast cancer metastasis, comparing and contrasting it with the established BALB/c 4T1 model. Metastatic EO771.LMB tumours were derived from poorly metastatic parental EO771 mammary tumours. Functional differences were evaluated using both in vitro assays and spontaneous metastasis assays in mice. Results were compared to non-metastatic 67NR and metastatic 4T1.2 tumours of the 4T1 model. Protein and transcript levels of markers of human breast cancer molecular subtypes were measured in the four tumour lines, as well as p53 (Tp53) tumour-suppressor gene status and responses t...
https://epubs.rcsi.ie/mctart/74
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Mark
Lipid Raft association restricts CD44-ezrin interaction and promotion of breast cancer cell migration.
(2012)
Donatello, Simona; Babina, Irina S; Hazelwood, Lee D; Hill, Arnold DK; Nabi, Ivan R; Ho...
Lipid Raft association restricts CD44-ezrin interaction and promotion of breast cancer cell migration.
(2012)
Donatello, Simona; Babina, Irina S; Hazelwood, Lee D; Hill, Arnold DK; Nabi, Ivan R; Hopkins, Ann M
Abstract:
<p>This article is also available at <a href="http://www.sciencedirect.com/science/article/pii/S0002944012006670">http://www.sciencedirect.com/science/article/pii/S0002944012006670</a> or <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502863/">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502863/</a></p>
<p>Cancer cell migration is an early event in metastasis, the main cause of breast cancer-related deaths. Cholesterol-enriched membrane domains called lipid rafts influence the function of many molecules, including the raft-associated protein CD44. We describe a novel mechanism whereby rafts regulate interactions between CD44 and its binding partner ezrin in migrating breast cancer cells. Specifically, in nonmigrating cells, CD44 and ezrin localized to different membranous compartments: CD44 predominantly in rafts, and ezrin in nonraft compartments. After the induction of migration (either nonspecific or CD44-dr...
https://epubs.rcsi.ie/surgart/12
Marked
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An imbalance in progenitor cell populations reflects tumour progression in breast cancer primary culture models.
(2011)
Donatello, Simona; Hudson, Lance; Cottell, David C; Blanco, Alfonso; Aurrekoetxea, Igor...
An imbalance in progenitor cell populations reflects tumour progression in breast cancer primary culture models.
(2011)
Donatello, Simona; Hudson, Lance; Cottell, David C; Blanco, Alfonso; Aurrekoetxea, Igor; Shelly, Martin J; Dervan, Peter A; Kell, Malcolm R; Stokes, Maurice; Hill, Arnold DK; Hopkins, Ann M
Abstract:
<p>This article is also available from <a href="http://www.jeccr.com/content/pdf/1756-9966-30-45.pdf?bcsi_scan_A676AEF22227A21F=Kf3iE/S/sY/o/F74L1n9XdBnJTABAAAAnQ8GAA==&bcsi_scan_filename=1756-9966-30-45.pdf">http://www.jeccr.com/content/pdf/1756-9966-30-45</a></p>
<p>ABSTRACT: BACKGROUND: Many factors influence breast cancer progression, including the ability of progenitor cells to sustain or increase net tumour cell numbers. Our aim was to define whether alterations in putative progenitor populations could predict clinicopathological factors of prognostic importance for cancer progression. METHODS: Primary cultures were established from human breast tumour and adjacent non-tumour tissue. Putative progenitor cell populations were isolated based on co-expression or concomitant absence of the epithelial and myoepithelial markers EPCAM and CALLA respectively. RESULTS: Significant reductions in cellular senescence were observed in tumour ...
https://epubs.rcsi.ie/surgart/6
Marked
Mark
Development and validation of a clinical prediction rule to identify suspected breast cancer: a prospective cohort study
(2014)
Galvin, Rose; Joyce, Doireann; Downey, Eithne; Boland, Fiona; Fahey, Tom; Hill, Arnold K
Development and validation of a clinical prediction rule to identify suspected breast cancer: a prospective cohort study
(2014)
Galvin, Rose; Joyce, Doireann; Downey, Eithne; Boland, Fiona; Fahey, Tom; Hill, Arnold K
Abstract:
Background: The number of primary care referrals of women with breast symptoms to symptomatic breast units (SBUs) has increased exponentially in the past decade in Ireland. The aim of this study is to develop and validate a clinical prediction rule (CPR) to identify women with breast cancer so that a more evidence based approach to referral from primary care to these SBUs can be developed. Methods: We analysed routine data from a prospective cohort of consecutive women reviewed at a SBU with breast symptoms. The dataset was split into a derivation and validation cohort. Regression analysis was used to derive a CPR from the patient’s history and clinical findings. Validation of the CPR consisted of estimating the number of breast cancers predicted to occur compared with the actual number of observed breast cancers across deciles of risk. Results: A total of 6,590 patients were included in the derivation study and 4.9% were diagnosed with breast cancer. Independent clinical predictors...
http://hdl.handle.net/10344/4757
Marked
Mark
South Central Strategic Health Authority: Cancer inequalities
(2007)
Oxford Cancer Intelligence Unit
South Central Strategic Health Authority: Cancer inequalities
(2007)
Oxford Cancer Intelligence Unit
Abstract:
This fact sheet focuses on the relationship between inequalities in cancer incidence, mortality and survival for the four most common cancers (lung, colorectal, breast and prostate) and levels of deprivation and certain lifestyle factors in local communities in the South Central SHA. The report is intended to inform the debate about priorities for reducing inequalities in the cancer burden and in outcomes for cancer patients in local communities.
http://dx.doi.org/10.14655/6744-29370
Marked
Mark
Reply: cost-effectiveness of population-based screening for colorectal cancer.
(2013)
Sharp, Linda; Walsh, Cathal Dominic; Whyte, Sophie; Tilson, Lesley; O'Ceilleachair...
Reply: cost-effectiveness of population-based screening for colorectal cancer.
(2013)
Sharp, Linda; Walsh, Cathal Dominic; Whyte, Sophie; Tilson, Lesley; O'Ceilleachair, Alan; Usher, Cara; Tappenden, Paul; Chilcott, James; Staines, Anthony; Barry, Michael; Comber, Harry
Abstract:
In his letter, Dr O’Mahony (2012) makes two main points. The first of these relates to the number of alternatives explored during our assessment of colorectal cancer screening in Ireland (Sharp et al, 2012), and the second relates to the terminology used in the paper. Our paper reports findings from a health technology assessment (HTA) of colorectal cancer screening; the full report has been published (Health Information and Quality Authority, 2009a). The purpose of HTA is to inform decision makers about the relative efficacy and costs of possible health-care interventions in order that coherent policy decisions can be taken. In the case of our work, the question of interest was whether population screening for colorectal cancer in Ireland would be effective and cost effective.
PUBLISHED
peer-reviewed
http://hdl.handle.net/10344/4929
Marked
Mark
Exercise in cancer care in Ireland: a survey of oncology nurses and physiotherapists
(2014)
O'Hanlon, É.; Kennedy, N.
Exercise in cancer care in Ireland: a survey of oncology nurses and physiotherapists
(2014)
O'Hanlon, É.; Kennedy, N.
Abstract:
Exercise is increasingly being promoted as an effective intervention to address the physical and psychosocial problems associated with cancer and its treatment (Kirshbaum 2007). Several trials have shown that exercise and keeping active throughout the cancer journey can preserve or improve physical function and psychological well-being and reduce the negative impact of some cancer- related side-effects such as fatigue (Schmitz et al . 2010
http://hdl.handle.net/10147/321661
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