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Displaying Results 251 - 275 of 3617 on page 11 of 145

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Implementing Ireland’s first national population-based colorectal cancer screening programme (2010)

National Cancer Screening Service (NCSS)

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All Ireland cancer statistics 1994-96 a joint report on incidence and mortality on the island of Ireland (2001)

National Cancer Registry Ireland; Northern Ireland Cancer Registry

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An oral cancer screening study of high risk individuals (2008)

O'Sullivan, Eleanor

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Biological evaluation of N-Ferrocenyl amino acid and dipeptide ester derivatives as potential anti-cancer agents and investigation into their mode of action in preparation for in vivo evaluation. (2014)

Murphy, James

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Androgen receptor signaling in prostate cancer development and progression (2011)

LONERGAN, PETER EOIN

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Transferrin conjugation does not increase the efficiency of liposomal Foscan during in vitro photodynamic therapy of oesophageal cancer (2013)

EHRHARDT, CARSTEN; SENGE, MATHIAS; PASZKO, EDYTA

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Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells. (2002)

PIDGEON, GRAHAM

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The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. (2009)

HUGHES, DAVID JOHN

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Characterisation and manipulation of docetaxel resistant prostate cancer cell lines (2011)

RANI, SWETA; O'DRISCOLL, LORRAINE

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The Role of Epigenetics in Resistance to Cisplatin Chemotherapy in Lung Cancer (2011)

O'BYRNE, KEN; BARR, MARTIN; GRAY, STEVEN

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The role of epigenetics in resistance to cisplatin chemotherapy in lung cancer (2011)

GRAY, STEVEN; BARR, MARTIN; O'BYRNE, KEN

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Correlation of p16(INK4A) expression and HPV copy number with cellular FTIR spectroscopic signatures of cervical cancer cells. (2011)

MARTIN, CARA; O'LEARY, JOHN

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Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment. (2014)

O'NEILL, LUKE; LYSAGHT, JOANNE; CONROY, MELISSA

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Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival (2013)

MURRAY, JAMES

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Using resource modelling to inform decision making and service planning: The case of colorectal cancer screening in Ireland (2013)

WALSH, CATHAL; WALTON, CLAIR

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Improving outcomes for people with skin tumours including melanoma (update) (2010)

Northern Ireland Cancer Network (NICaN)

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University Research Proposal Submission Topics 2010 (2010)

Northern Ireland Cancer Network (NICaN)

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Developing ovarian cancer stem cell models: laying the pipeline from discovery to clinical intervention. (2014)

O'LEARY, JOHN; GALLAGHER, MICHAEL

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Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer. (2015)

Johnstone, Cameron N; Smith, Yvonne E; Cao, Yuan; Burrows, Allan D; Cross, Ryan SN; Lin...

Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer. (2015)

Johnstone, Cameron N; Smith, Yvonne E; Cao, Yuan; Burrows, Allan D; Cross, Ryan SN; Ling, Xiawei; Redvers, Richard P; Doherty, Judy P; Eckhardt, Bedrich L; Natoli, Anthony L; Restall, Christina M; Lucas, Erin; Pearson, Helen B; Deb, Siddhartha; Britt, Kara L; Rizzitelli, Alexandra; Li, Jason; Harmey, Judith H; Pouliot, Normand; Anderson, Robin L

Abstract:

<p>The original article is available at <a href="http://www.biologists.com">www.biologists.com</a></p>
<p>The translation of basic research into improved therapies for breast cancer patients requires relevant preclinical models that incorporate spontaneous metastasis. We have completed a functional and molecular characterisation of a new isogenic C57BL/6 mouse model of breast cancer metastasis, comparing and contrasting it with the established BALB/c 4T1 model. Metastatic EO771.LMB tumours were derived from poorly metastatic parental EO771 mammary tumours. Functional differences were evaluated using both in vitro assays and spontaneous metastasis assays in mice. Results were compared to non-metastatic 67NR and metastatic 4T1.2 tumours of the 4T1 model. Protein and transcript levels of markers of human breast cancer molecular subtypes were measured in the four tumour lines, as well as p53 (Tp53) tumour-suppressor gene status and responses t...