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Current Search:	'Cancer' in all fields;

Displaying Results 3626 - 3650 of 3653 on page 146 of 147

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Development of an Efficient Dual-Action GST-Inhibiting Anticancer Platinum(IV) Prodrug (2018)

Lee, Keefe Guang Zhi; Babak, Maria V; Weiss, A.; Dyson, Paul J; Nowak-Sliwinska, Patryc...

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Metabolic reprogramming of natural killer cells in obesity limits antitumor responses (2018)

Michelet, Xavier; Dyck, Lydia; Hogan, Andrew; Loftus, Roisin; Duquette, Danielle; Wei, ...

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses (2018)

Michelet, Xavier; Dyck, Lydia; Hogan, Andrew; Loftus, Roisin; Duquette, Danielle; Wei, Kevin; Beyaz, Semir; Tavakkoli, Ali; Foley, Cathriona; Donnelly, Raymond; O'Farrelly, Cliona; Raverdeau, Mathilde; Veron, Ashley; Pettee, William; O'Shea, Donal; Nikolajczyk, Barbara S; Mills, Kingston H.G.; Brenner, Michael B.; Finlay, David; Lynch, Lydia

Abstract:

Up to 49% of certain types of cancer are attributed to obesity, and potential mechanisms include overproduction of hormones, adipokines, and insulin. Cytotoxic immune cells, including natural killer (NK) cells and CD8+ T cells, are important in tumor surveillance, but little is known about the impact of obesity on immunosurveillance. Here, we show that obesity induces robust peroxisome proliferator-activated receptor (PPAR)-driven lipid accumulation in NK cells, causing complete ‘paralysis’ of their cellular metabolism and trafficking. Fatty acid administration, and PPARα and PPARδ (PPARα/δ) agonists, mimicked obesity and inhibited mechanistic target of rapamycin (mTOR)-mediated glycolysis. This prevented trafficking of the cytotoxic machinery to the NK cell–tumor synapse. Inhibiting PPARα/δ or blocking the transport of lipids into mitochondria reversed NK cell metabolic paralysis and restored cytotoxicity. In vivo, NK cells had blunted antitumor responses and failed to reduce tumor...

http://mural.maynoothuniversity.ie/13238/

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Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity (2020)

Mills, Kingston; O'Neill, Luke

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An exploration of the prognostic utility of shortened dynamic imaging protocols for PET-FDG scans (2019)

Wu, Qi; O'Sullivan, Finbarr; Muzi, Mark; Mankoff, David

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Multimodal Microscopy Distinguishes Extracellular Aggregation and Cellular Uptake of Single-Walled Carbon Nanohorns (2020)

Devereux, Stephen J.; Cheung, Shane; Daly, Harrison C.; O'Shea, Donal F.; Quinn, S...

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The role of the liver X receptor in mitotane therapy in adrenocortical carcinoma (2020)

Warde, Kate

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A glycotherapeutic approach to functionalize biomaterials-based systems (2020)

Gadekar, Anuja; Bhowmick, Sirsendu; Pandit, Abhay

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Perceptions of Light Pollution and its Impacts: Results of an Irish Citizen Science Survey (2020)

Espey, Brian

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Neuromuscular Electrical Stimulation (NMES) in the Management of Glioblastoma Multiforme (2020)

O'Connor, Dominic; Caulfield, Brian; Wright, Sarah; Lennon, Olive

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Diverse Immunoregulatory Roles of Oxysterols - The Oxidized Cholesterol Metabolites (2020)

Finlay, David

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Resazurin-based assay for quantifying living cells during alkaline phosphatase (ALP) release (2020)

Balbaied, Thanih; Moore, Eric

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Multi-parametric single cell evaluation defines distinct drug responses in healthy hematological cells that are retained in corresponding malignant cell types. (2020)

Majumder, Muntasir M; Leppa, Aino-Maija; Hellesoy, Monica; Dowling, Paul; Malyutina, Al...

Multi-parametric single cell evaluation defines distinct drug responses in healthy hematological cells that are retained in corresponding malignant cell types. (2020)

Majumder, Muntasir M; Leppa, Aino-Maija; Hellesoy, Monica; Dowling, Paul; Malyutina, Alina; Kopperud, Reidun; Bazou, Despina; Andersson, Emma; Parsons, Alun; Tang, Jing; Kallioniemi, Olli; Mustjoki, Satu; O'Gorman, Peter; Wennerberg, Krister; Porkka, Kimmo; Gjertsen, Bjorn T; Heckman, Caroline A

Abstract:

Innate drug sensitivity in healthy cells aids identification of lineage specific anti-cancer therapies and reveals off-target effects. To characterize the diversity in drug responses in the major hematopoietic cell types, we simultaneously assessed their sensitivity to 71 small molecules utilizing a multi-parametric flow cytometry assay and mapped their proteomic and basal signaling profiles. Unsupervised hierarchical clustering identified distinct drug responses in healthy cell subsets based on their cellular lineage. Compared to other cell types, CD19+ /B and CD56+ /NK cells were more sensitive to dexamethasone, venetoclax and midostaurin, while monocytes were more sensitive to trametinib. Venetoclax exhibited dose-dependent cell selectivity that inversely correlated to STAT3 phosphorylation. Lineage specific effect of midostaurin was similarly detected in CD19+ /B cells from healthy, acute myeloid leukemia and chronic lymphocytic leukemia samples. Comparison of drug responses in ...

http://mural.maynoothuniversity.ie/13578/