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Current Search:	'Cancer' in all fields;

Displaying Results 76 - 100 of 3507 on page 4 of 141

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A study of the relationships between perceived pain, social support, coping and quality of life in patients with advanced cancer (1999)

Wright, Shelagh

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A nested case-control study of adjuvant hormonal therapy persistence and compliance, and early breast cancer recurrence in women with stage I-III breast cancer (2013)

BENNETT, KATHLEEN

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Psychological interventions for women with non-metastatic breast cancer (Review) (2015)

Jassim, Ghufran A; Whitford, David L; Hickey, Anne; Carter, Ben

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Quality of life of Bahraini women with breast cancer: a cross sectional study. (2013)

Jassim, Ghufran Ahmed; Whitford, David L

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Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase. (2011)

McSherry, Elaine A; Brennan, Kieran; Hudson, Lance; Hill, Arnold DK; Hopkins, Ann M

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Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion. (2015)

Cooke, Niamh M; Spillane, Cathy D; Sheils, Orla; O'Leary, John; Kenny, Dermot

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Noncoding RNAs in prostate cancer: the long and the short of it. (2014)

LYNCH, THOMAS

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Type 2 diabetes and breast cancer - the role of hyperinsulinaemia in breast cancer development and mortality (2016)

Gallagher, Emily Jane

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Oral cancer incidence and survival rates in the Republic of Ireland, 1994-2009 (2016)

Ali, Hala; Sinnott, Sarah-Jo; Corcoran, Paul; Deady, Sandra E.; Sharp, Linda; Kabir, Zu...

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Aspirin and P2Y<inf>12</inf> inhibition attenuate platelet-induced ovarian cancer cell invasion (2015)

SHEILS, ORLA; O'LEARY, JOHN; SPILLANE, CATHY

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An Exploration of Nurse-led Models of Cancer Care in Ireland: A Mixed Method Study (2020)

PRABHUKELUSKAR, SNEHAL

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An examination of the pharmacology of HER2 inhibitor responses in cellular models of breast cancer (2014)

O'Neill, Fiona

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Cancer projections for Ireland 2015-2040 (2014)

National Cancer Registry

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'Pragmatic randomized controlled trial of individually prescribed exercise versus usual care in a heterogeneous cancer survivor population': a feasibility study PEACH trial: prescribed exercise after chemotherapy. (2010)

WALSH, JULIE; HUSSEY, JULIETTE; GUINAN, EMER; O'DONNELL, DEARBHAILE

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Melanoma-associated antigen family protein-D4: clinical significance and functional relevance in breast cancer (2010)

O'Driscoll, Lorraine

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Long-term activation of the pro-coagulant response after neoadjuvant chemoradiation and major cancer surgery. (2010)

PIDGEON, GRAHAM; REYNOLDS, JOHN; MAHER, STEPHEN; WHITE, BARRY; O'DONNELL, JAMES

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Trends and Patterns in Cancer Mortality in Northern Ireland (2010)

Donnelly, D.W.; Gavin, A.T.

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Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells (2011)

SMYTH, PAUL; O'LEARY, JOHN; O'TOOLE, SHARON; SPILLANE, CATHY; MARTIN, CARA; G...

Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells (2011)

SMYTH, PAUL; O'LEARY, JOHN; O'TOOLE, SHARON; SPILLANE, CATHY; MARTIN, CARA; GALLAGHER, MICHAEL; NORRIS, LUCY; CONLON, NIAMH; MCEVOY, LYNDA MARIE; FFRENCH, GEORGE BRENDAN; STORDAL, BRITTA; KEEGAN, HELEN; FINN, STEPHEN; MCENEANEY, VICTORIA; SHEILS, ORLA; CROWLEY, DARRAGH

Abstract:

Thrombosis is common in ovarian cancer. However, the interaction of platelets with ovarian cancer cells has not been critically examined. To address this, we investigated platelet interactions in a range of ovarian cancer cell lines with different metastatic potentials [HIO-80, 59M, SK-OV-3, A2780, A2780cis]. Platelets adhered to ovarian cancer cells with the most significant adhesion to the 59M cell line. Ovarian cancer cells induced platelet activation [P-selectin expression] in a dose dependent manner, with the most significant activation seen in response to the 59M cell line. The platelet antagonists [cangrelor, MRS2179, and apyrase] inhibited 59M cell induced activation suggesting a P2Y12 and P2Y1 receptor mediated mechanism of platelet activation dependent on the release of ADP by 59M cells. A2780 and 59M cells potentiated PAR-1, PAR-4, and TxA2 receptor mediated platelet activation, but had no effect on ADP, epinephrine, or collagen induced activation. Analysis of gene expres...