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'Engineering' in all fields;
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Displaying Results 176 - 200 of 9115 on page 8 of 365
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Modularization constructs in method engineering: towards common ground?
(2007)
Agerfalk, Par J.; Brinkkemper, Sjaak; Henderson-Sellers, Brian; Karlsson, Fredrik; Kell...
Modularization constructs in method engineering: towards common ground?
(2007)
Agerfalk, Par J.; Brinkkemper, Sjaak; Henderson-Sellers, Brian; Karlsson, Fredrik; Kelly, Steven; Ralyte, Jolita
Abstract:
Although the Method Engineering (ME) research community has reached considerable maturity, it has not yet been able to agree on the granularity and definition of the configurable parts of methods. This state of affairs is causing unnecessary confusion, especially with an ever increasing number of people contributing to ME research. There are several competing notions around, most significantly 'method fragments' and 'method chunks', but also 'method components' and 'process components' are used in some quarters and have also been widely published. Sometimes these terms are used interchangeably, but there appears to be important semantic and pragmatic differences. If the differences are unimportant, we should be able to come to an agreement on what construct to promote. Alternatively, the different constructs may serve different purposes and there is a need for them to coexist. If this is the case, it should be possible to pinpoint exactly how ...
http://hdl.handle.net/10344/2284
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Development of a laser based surface profilometer using the principle of optical triangulation
(2005)
Collins, David Andrew
Development of a laser based surface profilometer using the principle of optical triangulation
(2005)
Collins, David Andrew
Abstract:
The metrology industry is constantly looking for new ways to accurately and quickly inspect and digitise surface topographies including the calculation o f surface roughness parameters and generating point clouds (a collection o f 3-dimensional points which describe a surface or surfaces) for modelling or reverse engineering purposes. Many types o f profllometer systems currently exist and the past decade has seen the rise in popularity o f optical based systems, however most optical profilometers are expensive to purchase and to maintain. The development o f optical profilometers can also be exceptionally complex depending on the type o f system and its fragility may not make it suitable for m ost workshop or factory floor applications. This project covers the development of a profllometer using the principle of optical triangulation. The developed system has a scanning table area of 200 by 120 millimetres and a vertical measurement range of five millimetres. The position o f the ...
http://doras.dcu.ie/17264/
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Collaboration, conflict and control: report on the 4th workshop on open source software engineering
(2005)
Feller, Joseph; Fitzgerald, Brian; Hissam, Scott; Lakhani, Karim
Collaboration, conflict and control: report on the 4th workshop on open source software engineering
(2005)
Feller, Joseph; Fitzgerald, Brian; Hissam, Scott; Lakhani, Karim
Abstract:
Building on the success of the first three workshops in the series, which were held at ICSE 2001 (Toronto), ICSE 2002 (Orlando) and ICSE 2003 (Portland), the 4th Workshop on Open Source Software Engineering, ("Collaboration, Conflict and Control") brought together researchers and practitioners for the purpose of discussing the platforms and tools, techniques and processes, and the organizational structures that are used to support and sustain communication, collaboration and conflict resolution within and between open source software communities.
http://hdl.handle.net/10344/2596
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Engineering automated systems for pharmaceutical manufacturing: quality, regulations and business performance
(2006)
Meagher, Diarmuid P.
Engineering automated systems for pharmaceutical manufacturing: quality, regulations and business performance
(2006)
Meagher, Diarmuid P.
Abstract:
The pharmaceutical sector is very heavily regulated Drug safety regulations form one of the pillars of this regulation. The manufacture of pharmaceuticals is carried out in an environment of onerous regulatory requirements, often from several national and international regulatory bodies. The quality systems operated by drug manufacturers and their regulatory practices have an important impact on product quality. The quality and regulatory requirements apply not only to handling of the medicinal products, but also to the physical and electronic systems used in the manufacture of those products, and extend to automated systems used to support quality assurance operations. Design, development, building and support of such systems are ultimately the responsibility of the drug manufacturer. The quality and regulatory requirements for automated systems are passed down the supply chain to suppliers. In the last two decades of the 20th century there has been a proliferation in the use of co...
http://doras.dcu.ie/18079/
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Physiological system modelling
(2003)
Parthasarathy, Sekar
Physiological system modelling
(2003)
Parthasarathy, Sekar
Abstract:
Computer graphics has a major impact in our day-to-day life. It is used in diverse areas such as displaying the results of engineering and scientific computations and visualization, producing television commercials and feature films, simulation and analysis of real world problems, computer aided design, graphical user interfaces that increases the communication bandwidth between humans and machines, etc Scientific visualization is a well-established method for analysis of data, originating from scientific computations, simulations or measurements. The development and implementation of the 3Dgen software was developed by the author using OpenGL and C language was presented in this report 3Dgen was used to visualize threedimensional cylindrical models such as pipes and also for limited usage in virtual endoscopy. Using the developed software a model was created using the centreline data input by the user or from the output of some other program, stored in a normal text file. The model...
http://doras.dcu.ie/18152/
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Production of coated and free-standing engineering components using the HVOF (High Velocity Oxy-Fuel) process
(2003)
Stokes, Joseph
Production of coated and free-standing engineering components using the HVOF (High Velocity Oxy-Fuel) process
(2003)
Stokes, Joseph
Abstract:
The present study aims to establish the potential of producing various hard metal industrial thick components using the High Velocity Oxy-Fuel (HVOF) thermal spray process, rather than by sintering or casting techniques currently used. It is innovative in that generally research work earned out on this process focuses on coating technologies. In order to spray-form thick tungsten carbide cobalt (WC-Co) components, certain problems have to be overcome. More specifically these problems include minimizing residual stresses (which cause shape distortion in the components), therefore maintaining the integrity of the deposit on a microstructural scale. Residual stress arises during deposition and, in the present research, was reduced by limiting the rise and fluctuation of the deposition temperature. This was achieved by the utilization of a carbon dioxide cooling system and automated traverse movement of the spray gun, which together enabled continuous deposition at a steady temperature...
http://doras.dcu.ie/18232/
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Integrated computer aided design simulation and manufacture
(1989)
Diko, Faek
Integrated computer aided design simulation and manufacture
(1989)
Diko, Faek
Abstract:
Computer Aided Design (CAD) and Computer Aided Manufacture (CAM) have been investigated and developed since twenty years as standalone systems. A large number of very powerful but independent packages have been developed for Computer Aided Design,Aanlysis and Manufacture. However, in most cases these packages have poor facility for communicating with other packages. Recently attempts have been made to develop integrated CAD/CAM systems and many software companies are actively engaged in this field of engineering. In the present work an integrated system for Computer Aided Design, Analysis and Manufacture has been developed incorporating AutoCAD Draughting package, Finite Element Analysis software and NC machining software. In this system, the draughting and NC machining software are resident m a PC and the Finite Element and Mesh Generation programs are resident m the mainframe computer. Appropriate softwares have also been developed for effective communication between different p...
http://doras.dcu.ie/18503/
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The design of an aluminium alloy wheel using three dimensional finite element analysis and fatigue life prediction
(1996)
Doyle, Mary M.
The design of an aluminium alloy wheel using three dimensional finite element analysis and fatigue life prediction
(1996)
Doyle, Mary M.
Abstract:
Styling has always played a very important role in automobile design. This factor as well as the demands of new safety legislation in Europe and through out the world makes it a very competitive industry. This often leads to complex car designs which need to be produced and proof tested with a minimum lead time and expenditure. But these new designs and manufacturing technologies must be reliable, thus the automobile manufacturer is increasingly investigating and developing new design tools to help improve the quality of their products. Computer aided engineering helps reduce the time necessary to produce a new design. It also improves the quality of design. In this study computer aided design, finite element analysis and fatigue life prediction are the tools which have been used. The design of a cast aluminium alloy wheel has been optimised using the Finite Element technique. It simulates the behaviour of the wheel under it's working load conditions. IDEAS Master Series has b...
http://doras.dcu.ie/18532/
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An online learning environment to teach artificial neural networks
(1999)
Galvin, Gareth
An online learning environment to teach artificial neural networks
(1999)
Galvin, Gareth
Abstract:
This thesis presents a study to evaluate the benefits of the Internet as an environment for Computer Aided Learning (CAL). It comprises of research into, current and previous approaches to CAL, and presents an implementation of the authors own approach, with the MEng (Masters in Electronic Engineering) course of Artificial Neural Networks (ANN’s) as a template upon which to develop courseware. CAL strives to stimulate the user interactively so as to facilitate an optimum knowledge transfer between teacher and student. This project will show th a t the Internet offers such features as hypertext, graphics, sound and video, which when incorporated correctly can engage the student and provide a more intuitive learning experience. Artificial Neural Networks were chosen as a template subject because of its iterative nature which lends itself well to graphical analysis. This, combined with its computationally intensive algorithms, lends itself well to a CAL environment. An evaluation of...
http://doras.dcu.ie/18743/
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Automating the product derivation process in software product line engineering
(2013)
O'Leary, Pádraig; Botterweck, Goetz; Richardson, Ita
Automating the product derivation process in software product line engineering
(2013)
O'Leary, Pádraig; Botterweck, Goetz; Richardson, Ita
Abstract:
A variety of automated approaches for software product line engineering in general and product derivation in particular have been proposed. Unfortunately due to a range of reasons, many development organisations fail to get the maximum benefit from these approaches. Worse, the way many organisations use these approaches actually hampers effective product derivation. As a foundation for the successful adoption of automated approaches in product derivation, a better understanding of the underlying activities in industrial product derivation practices is required. By consolidating current knowledge from literature and industrial experience, we have developed a process framework that comprises important tasks, which product line stakeholders have to perform during product derivation. We outline how our framework can provide a link to automated approaches by providing product derivation context and facilitating tool support for the overall process.
http://hdl.handle.net/10344/3367
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Who are we doing global software engineering research for?
(2013)
Beecham, Sarah; O'Leary, Pádraig; Richardson, Ita; Baker, Sean; Noll, John
Who are we doing global software engineering research for?
(2013)
Beecham, Sarah; O'Leary, Pádraig; Richardson, Ita; Baker, Sean; Noll, John
Abstract:
Twelve years ago a group of practitioners and researchers came together to try to solve problems relating specifically to Global Software Engineering (GSE) practice. This paper aims to assess whether the many hundreds of GSE research papers written over this period have had an impact on practice. We conducted semi-structured interviews with senior managers and project managers from ten companies, four of which are large multinationals (three in Fortune 100); four are medium sized enterprises, and two are small startups. GSE research is perceived as useful by industry with all participants stating that studying the subject would improve GSE performance; but all were unanimous in saying they did not read articles on GSE. Practitioners go to books, blogs, colleagues, forums, experience reports of 1-2 pages in length, or depend on their own experience to solve problems in GSE. Controversially, many didn’t see GSE as separate from general project management. Practitioners don’t want fram...
http://hdl.handle.net/10344/3369
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The engineering, management, and philosophy of service-oriented information systems
(2009)
Mora, Manuel; Pinhanez, Claudio; O'Connor, Rory; Blake, Brian
The engineering, management, and philosophy of service-oriented information systems
(2009)
Mora, Manuel; Pinhanez, Claudio; O'Connor, Rory; Blake, Brian
Abstract:
In this special issue on “The Engineering, Management, and Philosophy of Service-Oriented Information Systems” for the International Journal of Information Systems and the Service Sector (IJISSS), are presented five high-quality research articles.
http://doras.dcu.ie/19773/
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4th International workshop on product line approaches in software engineering
(2013)
Rubin, Julia; Pleuss, Andreas; Botterweck, Goetz; Weiss, David M
4th International workshop on product line approaches in software engineering
(2013)
Rubin, Julia; Pleuss, Andreas; Botterweck, Goetz; Weiss, David M
Abstract:
This paper summarizes PLEASE 2013, the fourth edition of the PLEASE workshop series. The main goal of PLEASE is to encourage and promote the adoption of Software Product Line Engineering. To this end, we aim at bringing together researchers and industrial practitioners involved in developing families of related products in order to (1) facilitate a dialogue between these two groups and (2) initiate and foster long-term collaborations.
http://hdl.handle.net/10344/3665
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The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering.
(2007)
PRENDERGAST, PATRICK JOHN; O'BRIEN, FERGAL
The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering.
(2007)
PRENDERGAST, PATRICK JOHN; O'BRIEN, FERGAL
Abstract:
The permeability of scaffolds and other three-dimensional constructs used for tissue engineering applications is important as it controls the diffusion of nutrients in and waste out of the scaffold as well as influencing the pressure fields within the construct. The objective of this study was to characterize the permeability/fluid mobility of collagen-GAG scaffolds as a function of pore size and compressive strain using both experimental and mathematical modeling techniques. Scaffolds containing four distinct mean pore sizes (151, 121, 110, 96 microns) were fabricated using a freeze-drying process. An experimental device was constructed to measure the permeability of the scaffold variants at different levels of compressive strain (0, 14, 29 and 40% while a low-density open-cell foam cellular solids model utilizing a tetrakaidecahedral unit cell was used to accurately model the permeability of each scaffold variant at all level of applied strain. The results of both the experimental...
http://hdl.handle.net/2262/39607
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Factor substitution and demand for labour in the Northern Ireland engineering industry
(1972)
Glass, J. C.
Factor substitution and demand for labour in the Northern Ireland engineering industry
(1972)
Glass, J. C.
Abstract:
The following analysis is not concerned with the question of what products should be produced in Northern Ireland, or what techniques of production should be used?rather it attempts to evaluate the existing policy of capital subsidisation in terms of its "potential" effect on the demand for labour in the Northern Ireland engineering industry. The purpose of the present study is co determine the effect, on employment, of the change in relative factor prices, (and where necessary to indicate the change in output required to offset this effect).
http://hdl.handle.net/2262/6997
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Mechanical characterisation of a customised decellularized scaffold for vascular tissue engineering
(2012)
MURPHY, BRUCE; DUFFY, GARRY; SHERIDAN, WILLIAM STEPHEN
Mechanical characterisation of a customised decellularized scaffold for vascular tissue engineering
(2012)
MURPHY, BRUCE; DUFFY, GARRY; SHERIDAN, WILLIAM STEPHEN
Abstract:
Several challenges persist when attempting to utilise decellularized tissue as a scaffold for vascular tissue engineering. Namely: poor cell infiltration/migration, excessive culture times associated with repopulating the scaffolds, and the achievement of a quiescent medial layer. In an attempt to create an optimum vascular scaffold we customised the properties of decellularized porcine carotid arteries by: (i) creating cavities within the medial layer to allow direct injection of cells, and (ii) controlling the amount of collagen digestion to increase the porosity. Histological examination of our customised scaffold revealed a highly porous tissue structure containing consistent medial cavities running longitudinally through the porous scaffold wall. Mechanical testing of the customised scaffold showed that our minimal localised disruption to the ECM does not have a detrimental effect on the bulk mechanical response of the tissue. The results demonstrate that an increased stiffness...
http://hdl.handle.net/2262/62425
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Engineering osteochondral constructs through spatial regulation of endochondral ossification.
(2013)
KELLY, DANIEL; BUCKLEY, CONOR
Engineering osteochondral constructs through spatial regulation of endochondral ossification.
(2013)
KELLY, DANIEL; BUCKLEY, CONOR
Abstract:
Chondrogenically primed bone marrow derived mesenchymal stem cells (MSCs) have been shown to become hypertrophic and undergo endochondral ossification when implanted in vivo. Modulating this endochondral phenotype may be an attractive approach to engineering the osseous phase of an osteochondral implant. The objective of this study was to engineer an osteochondral tissue by promoting endochondral ossification in one layer of a bi-layered construct and stable cartilage in the other. The top-half of bi-layered agarose hydrogels were seeded with culture expanded chondrocytes (termed chondral layer) and the bottom half of the bi-layered agarose hydrogels with MSCs (termed osseous layer). Constructs were cultured in a chondrogenic medium for 21 days and thereafter were either maintained in a chondrogenic medium, transferred to a hypertrophic medium, or implanted subcutaneously into nude mice. This structured chondrogenic bi-layered co-culture was found to enhance chondrogenesis in the ch...
http://hdl.handle.net/2262/66899
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Model driven engineering of cross-layer monitoring and adaptation
(2013)
Song, Hui; Raj, Amit; Hajebi, Saeed; Clarke, Siobhán; Clarke, Aidan
Model driven engineering of cross-layer monitoring and adaptation
(2013)
Song, Hui; Raj, Amit; Hajebi, Saeed; Clarke, Siobhán; Clarke, Aidan
Abstract:
Monitoring and adaptation of multilayer systems are challenging, because the mismatches and adaptations are interrelated across the layers. This interrelation introduces two important but difficult questions. 1) When a system change causes mismatches in one layer, how to identify all the cascaded mismatches on the other layers? 2) When an adaptation is performed at one layer, how to find out all the complementary adaptations required in other layers. This paper presents a model-driven engineering approach towards cross-layer monitoring and adaption of multilayer systems. We provide standard meta-modeling languages for system experts to specify the concepts and constraints separately for each layer, as well as the relations among the concepts from different layers. An automated engine uses these meta-level specifications to 1) represent the system states on each layer as a runtime model, 2) evaluate the constraints to detect mismatches and assist adaptations within a layer, and 3) sy...
http://hdl.handle.net/10344/3120
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Systems and software engineering standards for very small entities: implementation and initial results
(2014)
Laporte, Claude; O'Connor, Rory
Systems and software engineering standards for very small entities: implementation and initial results
(2014)
Laporte, Claude; O'Connor, Rory
Abstract:
Very small entities, organizations with up to 25 people, are very important to the worldwide economy. However it has been established that such companies often do not utilize existing best practice standards and frameworks. To address the needs of Very Small Entities (VSEs), a set of international standards and guides known as ISO/IEC 29110 has been developed. In this paper we present the results of early trials of this standard in an IT start-up and in an engineering enterprise and assess the lessons learnt for future research and industrial usage of this standard.
http://doras.dcu.ie/20273/
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Software process improvement in graduate software engineering programs
(2015)
Laporte, Claude; O'Connor, Rory
Software process improvement in graduate software engineering programs
(2015)
Laporte, Claude; O'Connor, Rory
Abstract:
At the École de technologie supérieure (ÉTS), software process improvement (SPI) is taught in lecture format and with a 10-week implementation project in an organization by teams of students of the graduate software engineering curriculum. The SPI course is taught using a ‘problem- goal-solution’ approach where students learn that any process improvement initiative must be based on issues preventing an organization in achieving its organizational goals whether the organization is a company or a not-for- profit organization. An important aspect of this course is the management of technological change where students learn and put in practice in their project the ‘soft’ issues which are part of most SPI organizational initiatives.
http://doras.dcu.ie/20670/
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The effects of collagen concentration and crosslink density on the biological, structural and mechanical properties of collagen-GAG scaffolds for bone tissue engineering.
(2009)
Tierney, Claire M; Haugh, Matthew G; Liedl, Jakob; Mulcahy, Fergal; Hayes, Brian; O...
The effects of collagen concentration and crosslink density on the biological, structural and mechanical properties of collagen-GAG scaffolds for bone tissue engineering.
(2009)
Tierney, Claire M; Haugh, Matthew G; Liedl, Jakob; Mulcahy, Fergal; Hayes, Brian; O'Brien, Fergal J
Abstract:
The original publication is available at http://www.sciencedirect.com
In this study, we examined the effects of varying collagen concentration and crosslink density on the biological, structural and mechanical properties of collagen-GAG scaffolds for bone tissue engineering. Three different collagen contents (0.25%, 0.5% and 1% collagen) and two different dehydrothermal (DHT) crosslinking processes [1] 105 degrees C for 24 h and [2] 150 degrees C for 48 h were investigated. These scaffolds were assessed for (1) pore size, (2) permeability (3) compressive strength and (4) cell viability. The largest pore size, permeability rate, compressive modulus, cell number and cell metabolic activity was all found to occur on the 1% collagen scaffold due to its increased collagen composition and the DHT treatment at 150 degrees C was found to significantly improve the mechanical properties and not to affect cellular number or metabolic activity. These results indicate that doubling the colla...
https://epubs.rcsi.ie/anatart/9
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The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering.
(2007)
O'Brien, Fergal J; Harley, Brendan A A; Waller, Mary A A; Yannas, Ioannis V V; Gib...
The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering.
(2007)
O'Brien, Fergal J; Harley, Brendan A A; Waller, Mary A A; Yannas, Ioannis V V; Gibson, Lorna J; Prendergast, Patrick J
Abstract:
This article is also available at http://iospress.metapress.com/content/103189/
The permeability of scaffolds and other three-dimensional constructs used for tissue engineering applications is important as it controls the diffusion of nutrients in and waste out of the scaffold as well as influencing the pressure fields within the construct. The objective of this study was to characterize the permeability/fluid mobility of collagen-GAG scaffolds as a function of pore size and compressive strain using both experimental and mathematical modeling techniques. Scaffolds containing four distinct mean pore sizes (151, 121, 110, 96 microns) were fabricated using a freeze-drying process. An experimental device was constructed to measure the permeability of the scaffold variants at different levels of compressive strain (0, 14, 29 and 40% while a low-density open-cell foam cellular solids model utilizing a tetrakaidecahedral unit cell was used to accurately model the permeability of each s...
https://epubs.rcsi.ie/anatart/5
Marked
Mark
Chitosan for gene delivery and orthopedic tissue engineering applications.
(2013)
Raftery, Rosanne; O'Brien, Fergal; Cryan, Sally-Ann
Chitosan for gene delivery and orthopedic tissue engineering applications.
(2013)
Raftery, Rosanne; O'Brien, Fergal; Cryan, Sally-Ann
Abstract:
<p>This article is also available at <a href="http://www.mdpi.com/1420-3049/18/5/5611">http://www.mdpi.com/1420-3049/18/5/5611</a></p>
<p>Gene therapy involves the introduction of foreign genetic material into cells in order exert a therapeutic effect. The application of gene therapy to the field of orthopaedic tissue engineering is extremely promising as the controlled release of therapeutic proteins such as bone morphogenetic proteins have been shown to stimulate bone repair. However, there are a number of drawbacks associated with viral and synthetic non-viral gene delivery approaches. One natural polymer which has generated interest as a gene delivery vector is chitosan. Chitosan is biodegradable, biocompatible and non-toxic. Much of the appeal of chitosan is due to the presence of primary amine groups in its repeating units which become protonated in acidic conditions. This property makes it a promising candidate for non-viral gene de...
https://epubs.rcsi.ie/anatart/58
Marked
Mark
Development of a biomimetic collagen-hydroxyapatite scaffold for bone tissue engineering using a SBF immersion technique.
(2009)
Al-Munajjed, Amir A; Plunkett, Niamh A; Gleeson, John P; Weber, Tim; Jungreuthmayer, Ch...
Development of a biomimetic collagen-hydroxyapatite scaffold for bone tissue engineering using a SBF immersion technique.
(2009)
Al-Munajjed, Amir A; Plunkett, Niamh A; Gleeson, John P; Weber, Tim; Jungreuthmayer, Christian; Levingstone, Tanya; Hammer, Joachim; O'Brien, Fergal J
Abstract:
This article is available at http://www3.interscience.wiley.com
The objective of this study was to develop a biomimetic, highly porous collagen-hydroxyapatite (HA) composite scaffold for bone tissue engineering (TE), combining the biological performance and the high porosity of a collagen scaffold with the high mechanical stiffness of a HA scaffold. Pure collagen scaffolds were produced using a lyophilization process and immersed in simulated body fluid (SBF) to provide a biomimetic coating. Pure collagen scaffolds served as a control. The mechanical, material, and structural properties of the scaffolds were analyzed and the biological performance of the scaffolds was evaluated by monitoring the cellular metabolic activity and cell number at 1, 2, and 7 days post seeding. The SBF-treated scaffolds exhibited a significantly increased stiffness compared to the pure collagen group (4-fold increase), while a highly interconnected structure (95%) was retained. FTIR indicated that the...
https://epubs.rcsi.ie/anatart/12
Marked
Mark
Mechanical characterization of a customized decellularized scaffold for vascular tissue engineering.
(2012)
Sheridan, W S; Duffy, Garry P; Murphy, B P
Mechanical characterization of a customized decellularized scaffold for vascular tissue engineering.
(2012)
Sheridan, W S; Duffy, Garry P; Murphy, B P
Abstract:
<p>This article is also available at <a href="http://www.journals.elsevier.com/journal-of-the-mechanical-behavior-of-biomedical-materials/">http://www.journals.elsevier.com/journal-of-the-mechanical-behavior-of-biomedical-materials/</a> or <a href="http://www.sciencedirect.com/science/article/pii/S1751616111003043">http://www.sciencedirect.com/science/article/pii/S1751616111003043</a></p>
<p>Several challenges persist when attempting to utilize decellularized tissue as a scaffold for vascular tissue engineering. Namely: poor cell infiltration/migration, excessive culture times associated with repopulating the scaffolds, and the achievement of a quiescent medial layer. In an attempt to create an optimum vascular scaffold, we customized the properties of decellularized porcine carotid arteries by: (i) creating cavities within the medial layer to allow direct injection of cells, and (ii) controlling the amount of collag...
https://epubs.rcsi.ie/anatart/54
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