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Displaying Results 19601 - 19625 of 19640 on page 785 of 786

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Mobilising Finance for Biodiversity: A policy and institutional review of finance arrangements for biodiversity conservation in Ireland (2021)

Mc Guinness, Shane; Bullock, Craig

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Quantitative analysis of weakly bound insulin oligomers in solution using polarized multidimensional fluorescence spectroscopy (2021)

Casamayou-Boucau, Yannick; Ryder, Alan G.

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Review of claudin proteins as potential biomarkers for necrotizing enterocolitis (2021)

Griffiths, Victoria; Al Assaf, Niazy; Khan, Rizwan

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Science Communication: Stakeholder perceptions of Real-time Incentive Fisheries Management (2021)

Pedreschi, D.; Vigier, A.; Höffle, H.; Kraak, S.B.M.; Reid, D.G.

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A qualitative exploration of the benefits of and the barriers to volunteering for migrants (2020)

Dressel, Nichola

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An exploratory study of the peer support worker role within a multi-disciplinary mental health team: multiple perspectives in an Irish context (2018)

O'Dwyer O'Brien, Aisling

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Staff experiences of applying a social pedagogical intervention within a residential childcare setting in Ireland (2017)

Breen, Emma

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Connected, respected and contributing to their world: The case of sexual minority and non-minority young people in Ireland (2021)

Költő, András; Gavin, Aoife; Vaughan, Elena; Kelly, Colette; Molcho, Michal; Nic Gabhai...

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Male victims of intimate partner violence: a mixed methods exploration (2020)

O'Connor, Garrett

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Population‐based identity‐by‐descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia (2021)

Harold, Denise; Connolly, Siobhan; Riley, Brien P.; Kendler, Kenneth S.; McCarthy, Shan...

Population‐based identity‐by‐descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia (2021)

Harold, Denise; Connolly, Siobhan; Riley, Brien P.; Kendler, Kenneth S.; McCarthy, Shane E.; McCombie, William R.; Richards, Alex; Owen, Michael J.; O'Donovan, Michael C.; Walters, James; Wellcome Trust Case Control Consortium 2; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Donohoe, Gary; Gill, Michael; Corvin, Aiden; Morris, Derek W.

Abstract:

Genome‐wide association studies (GWASs) are highly effective at identifying common risk variants for schizophrenia. Rare risk variants are also important contributors to schizophrenia etiology but, with the exception of large copy number variants, are difficult to detect with GWAS. Exome and genome sequencing, which have accelerated the study of rare variants, are expensive so alternative methods are needed to aid detection of rare variants. Here we re‐analyze an Irish schizophrenia GWAS dataset (n = 3,473) by performing identity‐by‐descent (IBD) mapping followed by exome sequencing of individuals identified as sharing risk haplotypes to search for rare risk variants in coding regions. We identified 45 rare haplotypes (>1 cM) that were significantly more common in cases than controls. By exome sequencing 105 haplotype carriers, we investigated these haplotypes for functional coding variants that could be tested for association in independent GWAS samples. We identified one rare m...