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Current Search:	All of 'Patrick' and 'Madden' in all fields;

Displaying Results 1 - 25 of 79 on page 1 of 4

Mark

An exploration of the state and status of nature awareness, appreciation and education in the Irish primary school system (2019)

MADDEN, PATRICK ANTHONY

Trinity College Dublin

Doctoral thesis

peer-reviewed

Mark

The Base of Party Political Support in Ireland: An Update (2019)

Madden, David (David Patrick)

University College Dublin

Working paper

unknown

Mark

Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL. (2018)

O'Driscoll, Lorraine; Eustace, Alex J.; Conlon, Neil T.; McDermott, Martina S.J.; ...

Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL. (2018)

O'Driscoll, Lorraine; Eustace, Alex J.; Conlon, Neil T.; McDermott, Martina S.J.; Browne, Brigid C.; O'Leary, Patrick; Holmes, Frankie A.; Espina, Virginia; Liotta, Lance A.; O'Shaughnessy, Joyce; Gallagher, Clair; Rani, Sweta; Madden, Stephen F.; O'Brien, Neil A.; Ginther, Charles; Slamon, Dennis; Walsh, Naomi; Gallagher, William M.; Zagozdzon, Radoslaw; Watson, William R.

Abstract:

Background: Lapatinib has clinical efficacy in the treatment of trastuzumab-refractory HER2-positive breast cancer. However, a significant proportion of patients develop progressive disease due to acquired resistance to the drug. Induction of apoptotic cell death is a key mechanism of action of lapatinib in HER2-positive breast cancer cells. Methods: We examined alterations in regulation of the intrinsic and extrinsic apoptosis pathways in cell line models of acquired lapatinib resistance both in vitro and in patient samples from the NCT01485926 clinical trial, and investigated potential strategies to exploit alterations in apoptosis signalling to overcome lapatinib resistance in HER2-positive breast cancer. Results: In this study, we examined two cell lines models of acquired lapatinib resistance (SKBR3-L and HCC1954-L) and showed that lapatinib does not induce apoptosis in these cells. We identified alterations in members of the BCL-2 family of proteins, in particular MCL-1 and BA...

Full-text link

http://hdl.handle.net/2262/91091

Trinity College Dublin

Journal article

peer-reviewed

Mark

The Base of Party Political Support in Ireland: An Update (2020)

Madden, David (David Patrick)

University College Dublin

Journal article

unknown

Mark

Highly selective trace ammonium removal from dairy wastewater streams by aluminosilicate materials (2019)

O'Connor, Elaine; Kavanagh, Oisín N.; Chovan, Drahomir; Madden, David G.; Cronin, ...

University of Limerick

Journal article

peer-reviewed

Science Foundation Ireland

Mark

The impact of an economic boom on the level and distribution of well-being : Ireland, 1994-2001 (2010)

Madden, David (David Patrick)

University College Dublin

Working paper

unknown

Mark

Methods for studying dominance and inequality in population health (2012)

Madden, David (David Patrick)

University College Dublin

Working paper

unknown

Mark

Gender differences in mental well-being : a decomposition analysis (2009)

Madden, David (David Patrick)

University College Dublin

Working paper

unknown

Mark

The socioeconomic gradient of obesity in Ireland (2011)

Madden, David (David Patrick)

University College Dublin

Working paper

unknown

Mark

The socioeconomic gradient of obesity in Ireland (2010)

Madden, David (David Patrick)

University College Dublin

Working paper

unknown

Mark

A profile of obesity in Ireland, 2002-2007 (2010)

Madden, David (David Patrick)

University College Dublin

Working paper

unknown

Mark

Distributional characteristics for Ireland : a note (2010)

Madden, David (David Patrick)

University College Dublin

Working paper

unknown

Mark

Omitted variables, dynamic specification and tests for homogeneity (2010)

Madden, David (David Patrick)

University College Dublin

Working paper

unknown

Mark

How does unemployment affect direct and indirect tax reform? (2010)

Madden, David (David Patrick)

University College Dublin

Working paper

unknown

Mark

Labour supply, commodity demand and marginal tax reform (2010)

Madden, David (David Patrick)

University College Dublin

Working paper

unknown

Mark

Conditional demands and marginal tax reform (2010)

Madden, David (David Patrick)

University College Dublin

Working paper

unknown

Mark

An analysis of indirect tax reform in Ireland in the 1980s (2009)

Madden, David (David Patrick)

University College Dublin

Working paper

unknown

Mark

Marginal tax reform and the specification of consumer demand systems (2009)

Madden, David (David Patrick)

University College Dublin

Working paper

unknown

Mark

A new set of consumer demand estimates for Ireland (2009)

Madden, David (David Patrick)

University College Dublin

Working paper

unknown

Mark

Can we infer external effects from a study of the Irish indirect tax system? (2009)

Madden, David (David Patrick)

University College Dublin

Working paper

unknown

Mark

Results from a preliminary investigation into the reform of indirect taxation in Ireland (2009)

Madden, David (David Patrick)

University College Dublin

Working paper

unknown

Mark

Poverty in Ireland, 1987-1994 : a stochastic dominance approach (2009)

Madden, David (David Patrick); Smith, Fiona

University College Dublin

Journal article

unknown

Mark

Concentration curves, inequality and tax reform (2009)

Madden, David (David Patrick)

University College Dublin

Working paper

unknown

Mark

GP reimbursement and visiting behaviour in Ireland (2009)

Madden, David (David Patrick); Nolan, Brian; Nolan, Anne

University College Dublin

Working paper

unknown

Mark

Can we infer external effects from a study of the Irish indirect tax system? (2009)

Madden, David (David Patrick)

University College Dublin

Journal article

unknown

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