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All of 'Ph.D.', 'Trinity', 'College' and 'Dublin' in all fields;
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Displaying Results 101 - 125 of 3779 on page 5 of 152
Marked
Mark
Antimicrobial peptide preventing beer spoilage
(2012)
Kavanagh, Joanne Denise
Antimicrobial peptide preventing beer spoilage
(2012)
Kavanagh, Joanne Denise
Abstract:
THESIS 9707
Beer spoilage micro-organisms (BSMs) are a common threat to Master Brewers worldwide. Numerous studies have been carried out to date to overcome this problem, yet the most common preventative measure is the addition of chemical preservatives to the beverage. The aim of the research outlined in this thesis was to generate a series of Saccharomyces yeast strains with antimicrobial ability to minimize or eliminate beer spoilage micro-organisms without affecting the fermentation process. The human defensin, H?D-3, was chosen in this study due to its broad antimicrobial spectrum and nutraceutic potential. H?D-3 was cloned into Saccharomyces cerevisiae and Saccharomyces pastorianus on low and high copy number plasmids, under the control of a variety of gene promoters such as the inducible galactokinase (GAL1) promoter, the inducible a-glucosidase (AGT1) promoter, the constitutive translational elongation factor EF-1 alpha (TEF1) promoter and the constitutive phosphoglycera...
http://hdl.handle.net/2262/79064
Marked
Mark
Studies on the three cysteines of mouse glutathione s-transferase P1
(2006)
McManus, Gavin
Studies on the three cysteines of mouse glutathione s-transferase P1
(2006)
McManus, Gavin
Abstract:
THESIS 7809
The present study has identified the "alkahne thiol" of mGSTP1 originally described by Phillips and Mantle (1993) as cystein e-169. In addition cysteine-47 is confirmed as the reactive "neutral" pK thiol. Cysteine-14 in the C14* mutant is unreactive at neutral pH and only slowly reacts under alkaline conditions. Several key experiments however suggest that Cys-14 can form a disulphide with Cys-47 and this may occur under conditions when the basic dimeric structure is maintained. A comparison of the extent of reaction of DTNB with GSTP1 forms with only Cys-14 or only Cys-47 sum to a significantly lower value than obtained when both Cys-14 and Cys-47 are present. A simple mechanism to explain this is has been presented where an initial mixed disulphide between NTB and Cys-47 destabilises the ?2-loop allowing Cys-14 to attack the modified Cys-47 forming a stable disulphide between Cys-14 and Cys-47 and releasing NTB. Whether this thioredoxin like hal...
http://hdl.handle.net/2262/86501
Marked
Mark
Design, synthesis and physical evaluation of luminescent lanthanide-based supramolecular systems
(2007)
Stomeo, Floriana
Design, synthesis and physical evaluation of luminescent lanthanide-based supramolecular systems
(2007)
Stomeo, Floriana
Abstract:
THESIS 8570
This thesis entitled "Design, Synthesis and Physical Evaluation of Luminescent Lanthanide-based Supramolecular Systems" is divided into five chapters, and is in two parts. The first part. Chapter 2, deals with the synthesis and characterisation of naphthalimide-based and lanthanide-based luminescent pH sensors, for incorporation into hydrogels. The second part, Chapters 3 and 4, describes the design and the physical studies of chiral Eu III-based triple helicates, in partially aqueous and organic media.
http://hdl.handle.net/2262/86629
Marked
Mark
Irish housing and the global financial crisis of urbanisation
(2013)
Downey, D.D.
Irish housing and the global financial crisis of urbanisation
(2013)
Downey, D.D.
Abstract:
THESIS 10324
Due to a confluence of consecutive crisis events in Ireland since the global financial crisis of 2008 and under the greatly contracted credit cycle and debt-crisis of the Euro-area, global capital flows into Ireland's built environment, having previously operated to deepen the integration of Ireland's housing market into the neoliberal global financial system, have since switched away from pre-crisis high volume investment levels in Irish residential urbanisation. This has reduced the performance of Ireland's highly financialised housing system as a secondary circuit for the circulation, amplification and accumulation of capital value.
http://hdl.handle.net/2262/90103
Marked
Mark
Eachtra ghiolla an amar?in
(2010)
? Liath?in, P?draig
Eachtra ghiolla an amar?in
(2010)
? Liath?in, P?draig
Abstract:
THESIS 9483
Is ? a chuireas romham sa tr?chtas seo n? eagr?n den d?n Eachtra Ghiolla an Amar?in, le Donncha Rua Mac Conmara, a chur ar f?il. Seo d?n a scr?obhadh i l?r an ocht? c?ad d?ag, a chuireann s?os ar 'eachtra' a tharla don fhile agus ? ag taisteal ar an bhfarraige, s?os go dt? an Domhan ?ochtarach, agus ar ais abhaile. Feictear traidisi?n na haislinge, agus tionchar Virgil go h?irithe, sa mh?id sin.
http://hdl.handle.net/2262/90470
Marked
Mark
English travellers in France 1660-1715
(1970)
Sturdy, D. J.
English travellers in France 1660-1715
(1970)
Sturdy, D. J.
Abstract:
THESIS 10420
http://hdl.handle.net/2262/76967
Marked
Mark
Battle at long range : correspondence chess in Britain and Ireland, 1824-1914, a social and cultural history
(2009)
Harding, T. D.
Battle at long range : correspondence chess in Britain and Ireland, 1824-1914, a social and cultural history
(2009)
Harding, T. D.
Abstract:
THESIS 8821
http://hdl.handle.net/2262/76982
Marked
Mark
The evolution and space weather effects of solar coronal holes
(2011)
Krista, Larisza D.
The evolution and space weather effects of solar coronal holes
(2011)
Krista, Larisza D.
Abstract:
THESIS 9170
In recent years the role of space weather forecasting has grown tremendously as our society increasingly relies on satellite dependent technologies. As solar activity is the foremost important aspect of space weather, the forecasting of are and CME related transient geomagnetic storms has become a primary initiative. Minor magnetic storms caused by coronal holes (CHs) have also proven to be of high importance due to their long lasting and recurrent geomagnetic effects. In order to forecast CH related geomagnetic storms, the author developed an automated CH detection package (Coronal Hole Automated Recognition and Monitoring; CHARM) to replace the user-dependent CH boundary intensity thresholding methods used in previous studies. CHARM uses a local intensity thresholding method to identify low intensity regions in extreme ultraviolet or X-ray images. CHs are known to be regions of ?open? magnetic field and predominant polarity, which allowed the differentiation of CHs...
http://hdl.handle.net/2262/77037
Marked
Mark
d? magnetism in oxides and alkaline-earth hexaborides
(2014)
Ackland, Karl
d? magnetism in oxides and alkaline-earth hexaborides
(2014)
Ackland, Karl
Abstract:
THESIS 10700
http://hdl.handle.net/2262/77009
Marked
Mark
Mountifort Longfield
(1943)
Black, Robert D. C.
Mountifort Longfield
(1943)
Black, Robert D. C.
Abstract:
22.cc.42
http://hdl.handle.net/2262/77100
Marked
Mark
Sir Laurence Parsons, second Earl of Rosse, 1758-1841
(1963)
Atkinson, N. D.
Sir Laurence Parsons, second Earl of Rosse, 1758-1841
(1963)
Atkinson, N. D.
Abstract:
THESIS 97
http://hdl.handle.net/2262/77092
Marked
Mark
The rise of Persian independence, 820-1056 A.D.
(1935)
Uddin, Ata Mohy
The rise of Persian independence, 820-1056 A.D.
(1935)
Uddin, Ata Mohy
Abstract:
22.cc.55
http://hdl.handle.net/2262/77261
Marked
Mark
An account of the mesolithic and supposed epi-mesolithic cultures of Ireland and their place in European pre-history
(1959)
Liversage, G. D.
An account of the mesolithic and supposed epi-mesolithic cultures of Ireland and their place in European pre-history
(1959)
Liversage, G. D.
Abstract:
22.gg.47
http://hdl.handle.net/2262/77190
Marked
Mark
The Catholic Church and Radicalism in Ireland in the 1790s
(1993)
Keogh, D?ire
The Catholic Church and Radicalism in Ireland in the 1790s
(1993)
Keogh, D?ire
Abstract:
THESIS 2643
http://hdl.handle.net/2262/77184
Marked
Mark
Tertiary dykes in northwest Ireland: field occurrence, emplacement mechanisms, host rock deformation, and post-emplacement strain and denudation
(2006)
Bennett, Stuart D.
Tertiary dykes in northwest Ireland: field occurrence, emplacement mechanisms, host rock deformation, and post-emplacement strain and denudation
(2006)
Bennett, Stuart D.
Abstract:
THESIS 7989
This work provides insight into the Tertiary tectonic and stress history of northwest Ireland. It focuses on igneous dykes, as these are the only rocks of Tertiary age in the region. The work also looks at the fundamental processes of dyke emplacement and host rock deformation. Three groups of dykes, the West Connacht systems, and the Killala and Donegal-Kingscourt swarms, are studied. By analysing the forms of the dykes and their relationships with the host rock structure, it is shown that the dykes largely exploited pre-existing structures in the oldest host rocks, but propagated hydraulic fractures in segmented en echelon arrays in the relatively young Carboniferous host rock. It is shown that the West Connacht systems were emplaced under NW-SE extension, the Killala swarm under N-S extension, and the Donegal-Kingscourt swarm under NE-SW extension. It is envisaged that the E-W trend of the Killala swarm is representative of a swing in the crustal stresses, influen...
http://hdl.handle.net/2262/77862
Marked
Mark
Estimating exhumation from seismic stacking velocity data : a case study from the Slyne Basin, offshore NW Ireland
(2012)
Biancotto, Fr?d?ric
Estimating exhumation from seismic stacking velocity data : a case study from the Slyne Basin, offshore NW Ireland
(2012)
Biancotto, Fr?d?ric
Abstract:
THESIS 10218
Exhumation describes the vertical upward displacement of rocks due to the removal of overburden material. In this study, seismic velocity profiles from 2D and 3D seismic reflection datasets have been inverted to constrain the distribution and the magnitude of exhumation within the Slyne Basin, offshore NW Ireland. The method has already been successfully applied to 2D datasets from offshore Britain and Africa; this study is the first attempt to extract exhumation estimates from 3D seismic data. Inversion of 3D seismic velocity data yields a continuous map of exhumation across the entire 3D footprint. Exhumation estimates in this study from 2D seismic sections agree with estimates from co-located 3D data. However, there is greater scatter in the 2D-derived exhumation estimates, most easily seen at seismic line ties. This scatter in the 2D measurements arises because 2D seismic stacking velocities are less well constrained than 3D velocities. Together, the 2D and 3D s...
http://hdl.handle.net/2262/77867
Marked
Mark
Mechanical properties of diamond impregnated cobalt metal matrix
(2011)
Dwan, James D.
Mechanical properties of diamond impregnated cobalt metal matrix
(2011)
Dwan, James D.
Abstract:
THESIS 9298
Diamond Impregnated Metal Matrix (DIMM) composite materials are a class of materials used in cutting and drilling of stone and construction materials. This thesis examined the effects of diamond size and diamond concentration on various mechanical properties of Diamond Impregnated Cobalt Metal Matrix (DICoMM). The mechanical properties investigated were: fracture toughness, fatigue crack propagation, transverse rupture strength, absorbed impact energy (absorbed energy), hardness and erosive wear behaviour. A range of diamond sizes and diamond concentrations were used in the investigation. Due to the Powder Metallurgy (PM) manufacturing process percent theoretical density is an important factor which strongly affects the mechanical properties of PM type materials. The effects of percent theoretical density on the different mechanical properties were also investigated. The results reported and analysed show the various effects due to the addition of diamond to the coba...
http://hdl.handle.net/2262/77968
Marked
Mark
Process, precedent, and community : new learning environments for engineering design
(2014)
Holland, D?nal
Process, precedent, and community : new learning environments for engineering design
(2014)
Holland, D?nal
Abstract:
THESIS 10424
Project-based design courses are an increasingly conunon component of engineering education. Most engineering schools have traditionally emphasized the analytical and scientific aspects of the discipline, and an increase in practical and experiential learning represents a transformation of established approaches to teaching in these institutions. However, there are significant challenges to developing and delivering these courses. Minimal guidance is available to educators who face these challenges. In particular, there is a paucity of research aligning learning objectives with pedagogical theories and practical guidelines. This thesis makes a contribution to both research and practice in engineering design education. A pedagogical framework for a particular type of project-based engineering design course is developed. The framework is intended to guide the development and evaluation of learning environments for these courses. It consists of learning objectives in t...
http://hdl.handle.net/2262/78015
Marked
Mark
The spiralling swallow : a sociological auto-ethnography of "eating disorders(s)" and "recovery"
(2008)
O'Farrell, Br?d
The spiralling swallow : a sociological auto-ethnography of "eating disorders(s)" and "recovery"
(2008)
O'Farrell, Br?d
Abstract:
THESIS 8696
This thesis is a sociological auto-ethnography of "eating disorder(s)" and "recovery".Using creative methodologies, I have created an intersubjective, poly-vocal account of bodies in encounter with medicine. I position this thesis as a counter-narrative and narrative of resistance to the hegemonic narratives circulated in contemporary Western cultures about health, healing and dys-order. Exploring the impact of dualistic medicalised cultures upon the lived experience of the body, I have posed questions about and offered reflections upon "ontology" ("ways of being") and "epistemology" ("ways of knowing"). In doing so I have contributed to sociologies theories of "eating disorder(s)" and offered reflections and theory on "recovery" when sociology seems, apart from a single study (Garrett, 1998), to have forgotten about this experience.
http://hdl.handle.net/2262/78146
Marked
Mark
An investigation into the behavioural effects of polyamines, polyamine antagonsits and novel compounds in vivo
(2007)
Murphy, D?sir?e H.
An investigation into the behavioural effects of polyamines, polyamine antagonsits and novel compounds in vivo
(2007)
Murphy, D?sir?e H.
Abstract:
THESIS 8126
The polyamines, putrescine, spermidine and spermine are ubiquitous compounents of eukaryotric cells in nature and are found in high concentrations in brain tissue. Polyamines have been implicated in cell growth, differentiation and nerve regeneration, but at high doses are neurotoxic. Administration of spermine (100?g icv) causes CNS excitation culminating in fatal tonic convulsions, within 8 hours. It is thought that spermine mediates this effect at least in part, through enhancement of activity on the NMDA receptor through positive modulatory extracellular binding site on the NMDA macrocomplex. To further enhance understanding of the mechanism of action of polyamines the antagonist potential of NMDA receptor antagonist, calcium channel antagonists, N1- dansylspermine and 6 novel polyamine analogues (Bu 31b, Bu 37b, Bu 33b, Bu 40b, Bu 36b and Bu 43b) from Brock University Canada, was assessed in the spermine CNS excitation model. The investigation revealed that the ...
http://hdl.handle.net/2262/78114
Marked
Mark
A study of the potential of adult mesenchymal stem cells in bone and cartilage tissue engineering
(2006)
Farrell, Eric
A study of the potential of adult mesenchymal stem cells in bone and cartilage tissue engineering
(2006)
Farrell, Eric
Abstract:
THESIS 7896
Adult mesenchymal stem cells (MSCs) have the potential to self-renew and differentiate into bone, cartilage, fat and muscle cells. This cell population offers significant potential for engineering of musculoskeletal tissue. The aim of my PhD was to generate viable bone and cartilage constructs from MSCs. Successful tissue engineering requires a suitable 3-dimensional (3-D) environment, which was provided by a novel collagen glycosaminoglycan (Collagen-GAG) scaffold. Bone and cartilage formation from adult MSCs seeded onto collagen GAG scaffolds was induced and some of the intracellular signalling mechanisms behind this process were characterised. My work optimised the techniques required to culture MSCs for an extended period of time and verified the presence of MSCs in culture and their proliferation capacity. My first study examined the potential for MSCs to be directed along the osteogenic pathway in a 2-D environment. To that end, cells were treated with osteoind...
http://hdl.handle.net/2262/78375
Marked
Mark
Urban development : use of a neural network mode choice model
(2002)
Heaney, Quentin R. D.
Urban development : use of a neural network mode choice model
(2002)
Heaney, Quentin R. D.
Abstract:
THESIS 6800
It is a requirement of the EU that member states undertake the development of urban transport in a sustainable manner. According to the EU the key elements in a sustainable strategy are: -- reduction of the adverse impact of traffic congestion on a city?s efficiency, -- increased provision of attractive public transport services. This thesis examines urban development policy throughout Europe and identifies the necessary components for a more sustainable urban area. From literature it was found that urban density was considered to be the most important factor for reducing car use and increasing the use of environmentally friendly modes of transport - public transport, cycling and walking. It was found that population densities should be above 50 persons per hectare (pph) to begin to impact on the mode choice.
http://hdl.handle.net/2262/78415
Marked
Mark
Prediction of ground vibrations due to a tunnel boring machine
(2007)
Rahman, Muhammad Ekhlasur
Prediction of ground vibrations due to a tunnel boring machine
(2007)
Rahman, Muhammad Ekhlasur
Abstract:
THESIS 8114
Changing social needs and increases in traffic have led to the demand for increased infrastructure. Due to the limitation of space in urban areas, underground structures, such as tunnels, are becoming more important for potential infrastructure. Tunnelling under city streets has now become a common activity for nearly all types of transportation. The construction of a tunnel induces ground vibration, which may affect the existing surface structures, particularly when the tunnel is constructed in hard ground, such as rock, or is at shallow depth. It is necessary to ensure that historically and economically important structures will not be adversely affected by tunnel construction and that any effects will be within acceptable limits. This programme of research involved carrying out laboratory tests to determine the dynamic properties, such as the small strain shear stiffness and the damping ratio, of Dublin boulder clay. It also involved predicting, using 3-D finite e...
http://hdl.handle.net/2262/78601
Marked
Mark
Landlord responses to the Irish land war, 1879-1882
(2006)
Pole, Adam D.
Landlord responses to the Irish land war, 1879-1882
(2006)
Pole, Adam D.
Abstract:
THESIS 7911
This dissertation examines rural class conflict in Victorian Ireland at a critical point when the simmering antagonism of tenant farmers over access to and possession of the land became fused with a nationalist movement and exploded into agrarian agitation during the agricultural depression of the late 1870s. The starting point of this project was that previous accounts of the land war had fixated aknost entirely on the agrarian agitation of tenant farmers led by the Land League, but largely neglected to examine the responses of the landowners to this grave challenge. This study approaches the responses of landlords to the land agitation in two ways: by examining how landlords as individuals responded on their own estates and how landlords responded collectively in forming defence organisations to protect their class interests. It is argued that while landlords increasingly used legal strategies to enforce the payment of rent and thereby combat the land agitation, th...
http://hdl.handle.net/2262/78595
Marked
Mark
Analysis of the impact of SIGIRR on glial function
(2013)
Carney, D?nal
Analysis of the impact of SIGIRR on glial function
(2013)
Carney, D?nal
Abstract:
THESIS 9847
Many neurodegenerative diseases are associated with a shift towards a pro-inflammatory environment within the CNS, and this is believed to contribute to the progressive decline in cognitive function associated with these diseases. Activated glial cells are thought to be the driving force behind the development of a pro-inflammatory environment, and endogenous modulators of glial activity have emerged as targets for the treatment of chronic neuroinflammation. The objective of this thesis was to analyse the ability of one such molecule, SIGIRR, to act as a modulator of glial activation.
http://hdl.handle.net/2262/78836
Displaying Results 101 - 125 of 3779 on page 5 of 152
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