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Displaying Results 76 - 100 of 2981 on page 4 of 120

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Experimental validation of CFD modelling for thermal regulation o photovoltaic panels using phase change material (2011)

Sarwar, SARAH; MC CORMACK; Huang; Norton

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Differential filamentation of Candida albicans and C. dubliniensis is governed by nutrient regulation of UME6 expression (2010)

SULLIVAN, DEREK

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Counter-regulation in the IKK family. (2011)

O'NEILL, LUKE

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Substrate-Promoted Formation of a Catalytically Competent Binuclear Center and Regulation of Reactivity in a Glycerophosphodiesterase from Enterobacter aerogenes (2008)

Hadler, Kieran S.; Tanifum, Eric A.; Hsu-Chen Yip, Sylvia; Mitic, Natasa; Guddat, Luke ...

Substrate-Promoted Formation of a Catalytically Competent Binuclear Center and Regulation of Reactivity in a Glycerophosphodiesterase from Enterobacter aerogenes (2008)

Hadler, Kieran S.; Tanifum, Eric A.; Hsu-Chen Yip, Sylvia; Mitic, Natasa; Guddat, Luke W.; Jackson, Colin J.; Gahan, Lawrence R.; Nguyen, Kelly; Carr, Paul D.; Ollis, David L.; Hengge, Alvan C.; Larrabee, James A.; Schenk, Gerhard

Abstract:

The glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes is a promiscuous binuclear metallohydrolase that catalyzes the hydrolysis of mono-, di-, and triester substrates, including some organophosphate pesticides and products of the degradation of nerve agents. GpdQ has attracted recent attention as a promising enzymatic bioremediator. Here, we have investigated the catalytic mechanism of this versatile enzyme using a range of techniques. An improved crystal structure (1.9 Å resolution) illustrates the presence of (i) an extended hydrogen bond network in the active site, and (ii) two possible nucleophiles, i.e., water/hydroxide ligands, coordinated to one or both metal ions. While it is at present not possible to unambiguously distinguish between these two possibilities, a reaction mechanism is proposed whereby the terminally bound H2O/OH- acts as the nucleophile, activated via hydrogen bonding by the bridging water molecule. Furthermore, the presence of substrate promotes th...

http://eprints.maynoothuniversity.ie/3701/

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Regulation of Surfactant Protein B Gene Expression in Bone Marrow-Derived Cells (2009)

Field-Corbett, Ciara; English, Karen; O'Dea, Shirley

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Optimal metabolic regulation by temporal variation of enzyme activities: a control theoretic approach (2007)

Oyarzun, Diego; Ingalls, Brian; Kalamatianos, Dimitrios

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Performance enhancement of wind turbine power regulation by switched linear control (1996)

Leith, D. J.; Leithead, W.E.

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Sliding Doors Cost Measurement: The Net Economic Cost of Lax Regulation of the Irish Banking Sector (2012)

Connor, Gregory; O'Kelly, Brian

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Role of KLF4 in regulation of myocardin induced SMC differentiation in human smooth muscle stem progenitor cells (hSMSPC) (2013)

Govindarajan, Kalaimathi

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Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival (2013)

MURRAY, JAMES

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Regulation of IL-1?-induced NF-?B by hydroxylases links key hypoxic and inflammatory signaling pathways. (2013)

FALLON, PADRAIC

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Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways. (2013)

FALLON, PADRAIC

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Co-operative roles for DNA supercoiling and nucleoid-associated proteins in the regulation of bacterial transcription (2013)

DORMAN, CHARLES

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Charge profile analysis reveals that activation of pro-apoptotic regulators Bax and Bak relies on charge transfer mediated allosteric regulation. (2012)

Ionescu, Crina-Maria; Svobodová Vařeková, Radka; Prehn, Jochen HM; Huber, Heinrich J; K...

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Investigation into the role of La/SS-B in Interferon regulation and its relevance in health and human disease (2014)

Mahony, Rebecca G

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Regulating Everything: From Mega- to Meta-regulation (2012)

Scott, Colin

Irish Research Council for Humanities and Social Sciences

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Licensing as a Tool of Regulation and Governance (2014)

Scott, Colin

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An investigation into why companies delist from the main market on the Irish stock market to the Irish enterprise exchange and the impact of regulation (2009)

Harkin, Sarah

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Financial Industry Ontologies for Risk and Regulation Data (FIORD): a position paper (2014)

Koumpis, Adamantios

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Housing supply in Ireland since 1990: The role of costs and regulation (2015)

Lyons, Ronan C.

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Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFN? Regulation. (2015)

MCMANUS, ROSS

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Platelet aggregation induced by Caco-2 cells: regulation by matrix metalloproteinase-2 and adenosine diphosphate (2006)

RADOMSKI, MAREK; SANTOS-MARTINEZ, MARIA; MEDINA MARTIN, CARLOS

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Transcription of Interleukin-8: How Altered Regulation Can Affect Cystic Fibrosis Lung Disease. (2015)

Jundi, Karim; Greene, Catherine M

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Ashbury Private Nursing Home inspection report, 13 May 2014 (2014)

Health Information and Quality Authority (HIQA); Regulation Directorate

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A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function (2013)

Porcu, Eleonora; Medici, Marco; Pistis, Giorgio; Volpato, Claudia B.; Wilson, Scott G.;...

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function (2013)

Porcu, Eleonora; Medici, Marco; Pistis, Giorgio; Volpato, Claudia B.; Wilson, Scott G.; Cappola, Anne R.; Bos, Steffan D.; Deelen, Joris; den Heijer, Martin; Freathy, Rachel M.; Lahti, Jari; Liu, Chunyu; Lopez, Lorna M.; Nolte, Ilja M.; O'Connell, Jeffrey R.; Tanaka, Toshiko; Trompet, Stella; Arnold, Alice; Bandinelli, Stefania; Beekman, Marian

Abstract:

Thyroid hormone is essential for normal metabolism and development, and overt abnormalities in thyroid function lead to common endocrine disorders affecting approximately 10% of individuals over their life span. In addition, even mild alterations in thyroid function are associated with weight changes, atrial fibrillation, osteoporosis, and psychiatric disorders. To identify novel variants underlying thyroid function, we performed a large meta-analysis of genome-wide association studies for serum levels of the highly heritable thyroid function markers TSH and FT4, in up to 26,420 and 17,520 euthyroid subjects, respectively. Here we report 26 independent associations, including several novel loci for TSH (PDE10A, VEGFA, IGFBP5, NFIA, SOX9, PRDM11, FGF7, INSR, ABO, MIR1179, NRG1, MBIP, ITPK1, SASH1, GLIS3) and FT4 (LHX3, FOXE1, AADAT, NETO1/FBXO15, LPCAT2/CAPNS2). Notably, only limited overlap was detected between TSH and FT4 associated signals, in spite of the feedback regulation of t...

http://hdl.handle.net/10468/2394

Displaying Results 76 - 100 of 2981 on page 4 of 120

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