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Displaying Results 126 - 150 of 2088 on page 6 of 84

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Characterisation Of Cell Types In Abalone (Haliotis spp.) Tissues Using Immunohistochemical Techniques (2006)

Harris, Leanne; O'Byrne-Ring, Nuala; Lambkin, Helen

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The role of glycosylation in regulatory T-cell biology (2016)

Faria Ferreira Cabral, Joana Maria

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The population biology of Acanthocephalus clavula in European Eel Anguilla anguilla L., brown trout Salmo trutta L. and Asellus meridianus Rac., with special reference to the suitability of brown trout as a definitive host (2010)

Dooley, Emma Jane

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MicroRNA Profiling of Exosomes (2017)

O'Driscoll, Lorraine

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On the personalised modelling of cancer signalling (2017)

Fey, Dirk; Kuehn, Axel; Kholodenko, Boris N.

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Conservation biology of Saxifraga hirculus L. in Ireland (2012)

Muldoon, Caoimhe S

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Reproductive biology and parasite (Perkinsus marinus) prevalence in the eastern oyster, Crassostrea virginica, within a Georgia tidal river (1997)

O'Beirn, F.X.; Walker, R.L.; Jansen, M.L.

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AZA – the producing organisms – biology and trophic transfer (2014)

Tillmann, U.; Salas, R.; Jauffrais, T.; Hess, P.; Silke, J.

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Nucleophosmin: From structure and function to disease development (2016)

O'BYRNE, KEN

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Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell therapy. (2017)

do Amaral, Ronaldo JFC; Almeida, Henrique V; Kelly, Daniel J; O'Brien, Fergal J; K...

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Mechanistic investigation of developmental copper chemotherapeutics (2017)

Slator, Creina

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HOXC11 impacts steroidal adaptability in aromatase inhibitor resistance by up-regulating the androgen receptor (2017)

Ali Beegan, Azlena

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Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells (2017)

Lyons, Amy; Coleman, Michael; Riis, Sarah; Favre, Cedric; O'Flanagan, Ciara; Zhdan...

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Systematic analysis of the PTEN 5' leader identifies a major AUU initiated proteoform (2016)

Tzani, Ioanna; Ivanov, Ivaylo P.; Andreev, Dmitry E.; Dmitriev, Ruslan I.; Dean, Kellie...

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Stop codon readthrough generates a C-terminally extended variant of the human vitamin D receptor with reduced calcitriol response (2018)

Loughran, Gary; Jungreis, Irwin; Tzani, Ioanna; Power, Michael; Dmitriev, Ruslan I.; Iv...

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miR-155 Dysregulation and Therapeutic Intervention in Multiple Sclerosis. (2017)

McCoy, Claire E

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Redox biology response in germinating Phaseolus vulgaris seeds exposed to copper: evidence for differential redox buffering in seedlings and cotyledon (2017)

Karmous, Ines; Trevisan, Rafael; El Ferjani, Ezzedine; Chaoui, Abdelilah; Sheehan, David

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RNA phage biology in a metagenomic era (2018)

Callanan, Julie; Stockdale, Stephen; Shkoporov, Andrey; Draper, Lorraine A.; Ross, R. P...

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The palaeolimnology of Lough Murree, a brackish lake in The Burren, Ireland (2013)

Dalton, Catherine; Cassina, Filippo; de Eyto, Elvira; Sparber, Karin

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Integrating observed, inferred and simulated data to illuminate environmental change: a limnological case study (2016)

Dalton, Catherine; Jennings, Eleanor; O'Dwyer, Barry; Taylor, David

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The fisheries biology of commercial ray species from two geographically distinct regions (2001)

Gallagher, Michael J.

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Reproductive biology of the starry smooth-hound shark mustelus asterias: geographic variation and implications for sustainable exploitation (2018)

Farrell, E. D.; Mariani, S.; Clarke, M. W.

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Minimum landing size for northeast atlantic stocks of deep-water red crab, chaceon affinis (milne edwards and bouvier, 1894) (2018)

Robinson, M.

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Construction of synthetic nucleoli and what it tells us about propagation of sub-nuclear domains through cell division (2018)

Grob, Alice; McStay, Brian

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Estrogen withdrawal, increased breast cancer risk and the kras-variant (2018)

McVeigh, Terri P; Jung, Song-Yi; Kerin, Michael J; Salzman, David W; Nallur, Sunitha; N...

Estrogen withdrawal, increased breast cancer risk and the kras-variant (2018)

McVeigh, Terri P; Jung, Song-Yi; Kerin, Michael J; Salzman, David W; Nallur, Sunitha; Nemec, Antonio A; Dookwah, Michelle; Sadofsky, Jackie; Paranjape, Trupti; Kelly, Olivia; Chan, Elcie; Miller, Nicola; Sweeney, Karl J; Zelterman, Daniel; Sweasy, Joann; Pilarski, Robert; Telesca, Donatello; Slack, Frank J; Weidhaas, Joanne B

Abstract:

The KRAS-variant is a biologically functional, microRNA binding site variant, which predicts increased cancer risk especially for women. Because external exposures, such as chemotherapy, differentially impact the effect of this mutation, we evaluated the association of estrogen exposures, breast cancer (BC) risk and tumor biology in women with the KRAS-variant. Women with BC (n = 1712), the subset with the KRAS-variant (n = 286) and KRAS-variant unaffected controls (n = 80) were evaluated, and hormonal exposures, KRAS-variant status, and pathology were compared. The impact of estrogen withdrawal on transformation of isogenic normal breast cell lines with or without the KRAS-variant was studied. Finally, the association and presentation characteristics of the KRAS-variant and multiple primary breast cancer (MPBC) were evaluated. KRAS-variant BC patients were more likely to have ovarian removal pre-BC diagnosis than non-variant BC patients (p = 0.033). In addition, KRAS-variant BC pat...

http://hdl.handle.net/10379/12853

Displaying Results 126 - 150 of 2088 on page 6 of 84

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