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Redox biology response in germinating Phaseolus vulgaris seeds exposed to copper: evidence for differential redox buffering in seedlings and cotyledon (2017)

Karmous, Ines; Trevisan, Rafael; El Ferjani, Ezzeddine; Chaoui, Abdelilah; Sheehan, David

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Teacher Design Teams (TDTs) - building capacity for innovation, learning and curriculum implementation in the continuing professional development of in-career teachers (2007)

Mooney Simmie, Geraldine

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Potential of Vibrational Spectroscopy in the Diagnosis of Human Tumours. (2006)

O'Faolain, Eoghan

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Tinman Regulates NetrinB in the Cardioblasts of the Drosophila Dorsal Vessel. (2016)

LABRADOR, JUAN

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Applying quantitative methods to conservation planning : Population dynamics of the Eurasian otter in Ireland (2008)

? N?ill, Lughaidh

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Young people's perspectives on genetics, identity and society using film and discussion (2005)

Murphy, Padraig

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Biomarkers for Placental Abnormality (2005)

McCarthy, Cathal

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Release of HMGB1 in Response to Pro-Apoptotic Glioma Killing Strategies: Efficacy and Neurotoxicity (2010)

Candolfi, Marianela; Yagiz, Kader; Foulad, David; Alzadeh, Gabrielle; Tesarfreund, Matt...

Release of HMGB1 in Response to Pro-Apoptotic Glioma Killing Strategies: Efficacy and Neurotoxicity (2010)

Candolfi, Marianela; Yagiz, Kader; Foulad, David; Alzadeh, Gabrielle; Tesarfreund, Matthew; Muhammad, AKM Ghulam; Puntel, Mariana; Kroeger, Kurt; Liu, Chunyan; Lee, Sharon; Curtin, James; King, Gwendalyn D; Lerner, Jonathan; Sato, Katsuaki; Mineharu, Yohei; Xiong, Weidong; Lowenstein, Pedro R; Castro, Maria

Abstract:

Purpose In preparation for a Phase I clinical trial utilizing a combined cytotoxic/immunotherapeutic strategy using adenoviruses expressing Flt3L (Ad-Flt3L) and thymidine kinase (Ad-TK) to treat glioblastoma (GBM), we tested the hypothesis that Ad-TK+GCV would be the optimal tumor killing agent in relation to efficacy and safety when compared to other pro-apoptotic approaches. Experimental Design and Results The efficacy and neurotoxicity of Ad-TK+GCV was compared with Ads encoding the pro-apoptotic cytokines (TNF-α, TRAIL, FasL), alone or in combination with Ad-Flt3L. In rats bearing small GBMs (day 4), only Ad-TK+GCV or Ad-FasL improved survival. In rats bearing large GBMs (day 9), the combination of Ad-Flt3L with Ad-FasL did not improve survival over FasL alone, while Ad-Flt3L combined with Ad-TK+GCV led to 70% long-term survival. Expression of FasL and TRAIL caused severe neuropathology, which was not encountered when we utilized Ad-TK+/−Ad-Flt3L. In vitro, all treatments elicit...