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Displaying Results 176 - 200 of 1617 on page 8 of 65

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Maternal Health Behaviours During Pregnancy and Associations with Infant Feeding Factors (2010)

Tarrant, Roslyn; Younger, Katherine; Sheridan-Pereira, Margaret; Kearney, John

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Expression of Genes Involved in a Radiation-Induced Bystander Effect (2011)

Furlong, Hayley

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Numerical Simulations of in Vitro Nanoparticle Toxicity – the Case of Poly(amido amine) Dendrimers. (2014)

Maher, Marcus; Naha, Pratap; Mukherjee, Sourav Prasanna; Byrne, Hugh

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Teacher Design Teams (TDTs) - building capacity for innovation, learning and curriculum implementation in the continuing professional development of in-career teachers (2007)

Mooney Simmie, Geraldine

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Potential of Vibrational Spectroscopy in the Diagnosis of Human Tumours. (2006)

O'Faolain, Eoghan

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Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials. (2008)

Curtin, James; Candolfi, Marianela; Fakhouri, Tamer; Liu, Chunyan; Alden, Anderson; Edw...

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Turning the Gene Tap off; Implications of Regulating Gene Expression for Cancer Therapeutics (2008)

Curtin, James; Candolfi, Marianela; Xiong, Weidong; Lowenstein, Pedro; Castro, Maria

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Isolation of cancer stem cells from adult glioblastoma multiforme (2004)

Yuan, Xianpeng; Curtin, James; Xiong, Yizhi; Liu, Gentao; Waschsmann-Hogiu, Sebastian; ...

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Activation of MMP-9 by Human Lung Epithelial Cells in Response to the Cystic Fibrosis-Associated Pathogen Burkholderia Cenocepacia Reduced Wound Healing in Vitro (2011)

Wright, Ciara, ]; Pilkington, Ruth; Callaghan, Máire; McClean, Siobhan

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The Bio-Nano-Interface in Predicting Nanoparticle Fate and Behaviour in Living Organisms: Towards Grouping and Categorising Nanomaterials and Ensuring Nanosafety by Design (2013)

Byrne, Hugh; Ahluwalia, Arti; Boraschi,, Diana; Fadeel, Bengt; Gehr, Peter; Gutleb, Arn...

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Divergent Mechanisms of Interaction of Helicobacter Pylori and Campylobacter Jejuni with Mucus and Mucins (2013)

Naughton, Julie Ann; Mariño, Karina; Dolan, Brendan; Reid, Colm; Gough, Ronan; Gallaghe...

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Tinman Regulates NetrinB in the Cardioblasts of the Drosophila Dorsal Vessel. (2016)

LABRADOR, JUAN

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Applying quantitative methods to conservation planning : Population dynamics of the Eurasian otter in Ireland (2008)

? N?ill, Lughaidh

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Non-thermal Atmospheric Plasma Induces ROS-independent Cell Death in U373MG Glioma Cells and Augments the Cytotoxicity of Temozolomide (2016)

Conway, Gillian; Casey, Alan; Milosavljevic, Vladimir; Liu, Yupeng; Howe, Orla L; Culle...

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Young people's perspectives on genetics, identity and society using film and discussion (2005)

Murphy, Padraig

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Biomarkers for Placental Abnormality (2005)

McCarthy, Cathal

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Gene Therapy and Targeted Toxins for Glioma (2005)

Curtin, James; King, Gwendalyn; Candolfi, Marianela; Kroeger, Kurt; Lowenstein, Pedro; ...

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Combining Cytotoxic and Immune-Mediated Gene Therapy to Treat Brain Tumors (2005)

Curtin, James; King, Gwendalyn; Candolfi, Marianela; Greeno, Remy; Kroeger, Kurt; Lowen...

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Live and let die: regulatory mechanisms in Fas-mediated apoptosis (2003)

Curtin, James; Cotter, Thomas

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Transcriptional Regulation of Cholesterol 24-hydroxylase by Histone Deacetylase Inhibitors. (2009)

Shafaati, Marjan; O'Driscoll, Riona; Bjorkhem, Ingemar; Meaney, Steve

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JNK Regulates HIPK3 Expression and Promotes Resistance to Fas-mediated Apoptosis in DU 145 Prostate Carcinoma Cells (2004)

Curtin, James; Cotter, Thomas

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Defects in death-inducing signalling complex formation prevent JNK activation and Fas-mediated apoptosis in DU 145 prostate carcinoma cells (2003)

Curtin, James; Cotter, Thomas

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Study of the Efficacy, Biodistribution, and Safety Profile of Therapeutic Gutless Adenovirus Vectors as a Prelude to a Phase I Clinical Trial for Glioblastoma (2010)

Muhammad, AKM Ghulam; Puntel, Mariana; Candolfi, Marianela; Salem, A; Yagiz, Kader; Far...

Study of the Efficacy, Biodistribution, and Safety Profile of Therapeutic Gutless Adenovirus Vectors as a Prelude to a Phase I Clinical Trial for Glioblastoma (2010)

Muhammad, AKM Ghulam; Puntel, Mariana; Candolfi, Marianela; Salem, A; Yagiz, Kader; Farrokhi, C; Kroeger, Kurt; Xiong, Weidong; Curtin, James; Liu, Chunyan; Lawrence, K; Bondale, Niyati; Lerner, Jonathan; Baker, G; Foulad, David; Pechnick, Robert; Palmer, Donna; Ng, Philip; Lowenstein, Pedro; Castro, Maria

Abstract:

<p>Glioblastoma multiforme (GBM) is the most common and most aggressive primary brain tumor in humans. Systemic immunity against gene therapy vectors has been shown to hamper therapeutic efficacy; however, helper-dependent high-capacity adenovirus (HC-Ad) vectors elicit sustained transgene expression, even in the presence of systemic anti-adenoviral immunity. We engineered HC-Ads encoding the conditional cytotoxic herpes simplex type 1 thymidine kinase (TK) and the immunostimulatory cytokine fms-like tyrosine kinase ligand 3 (Flt3L). Flt3L expression is under the control of the regulatable Tet-ON system. In anticipation of a phase I clinical trial for GBM, we assessed the therapeutic efficacy, biodistribution, and clinical and neurotoxicity with escalating doses of HC-Ad-TetOn-Flt3L + HC-Ad-TK in rats. Intratumoral administration of these therapeutic HC-Ads in rats bearing large intracranial GBMs led to long-term survival in ~70% of the animals and development of antiglioma im...