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Displaying Results 176 - 200 of 1609 on page 8 of 65

Mark

Applying quantitative methods to conservation planning : Population dynamics of the Eurasian otter in Ireland (2008)

Ó Néill, Lughaidh

Trinity College Dublin

Doctoral thesis

unknown

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Young people's perspectives on genetics, identity and society using film and discussion (2005)

Murphy, Padraig

Dublin City University

Other

unknown

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Biomarkers for Placental Abnormality (2005)

McCarthy, Cathal

Dublin Institute of Technology

Other

unknown

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Release of HMGB1 in Response to Pro-Apoptotic Glioma Killing Strategies: Efficacy and Neurotoxicity (2010)

Candolfi, Marianela; Yagiz, Kader; Foulad, David; Alzadeh, Gabrielle; Tesarfreund, Matt...

Release of HMGB1 in Response to Pro-Apoptotic Glioma Killing Strategies: Efficacy and Neurotoxicity (2010)

Candolfi, Marianela; Yagiz, Kader; Foulad, David; Alzadeh, Gabrielle; Tesarfreund, Matthew; Muhammad, AKM Ghulam; Puntel, Mariana; Kroeger, Kurt; Liu, Chunyan; Lee, Sharon; Curtin, James; King, Gwendalyn D; Lerner, Jonathan; Sato, Katsuaki; Mineharu, Yohei; Xiong, Weidong; Lowenstein, Pedro R; Castro, Maria

Abstract:

Purpose In preparation for a Phase I clinical trial utilizing a combined cytotoxic/immunotherapeutic strategy using adenoviruses expressing Flt3L (Ad-Flt3L) and thymidine kinase (Ad-TK) to treat glioblastoma (GBM), we tested the hypothesis that Ad-TK+GCV would be the optimal tumor killing agent in relation to efficacy and safety when compared to other pro-apoptotic approaches. Experimental Design and Results The efficacy and neurotoxicity of Ad-TK+GCV was compared with Ads encoding the pro-apoptotic cytokines (TNF-α, TRAIL, FasL), alone or in combination with Ad-Flt3L. In rats bearing small GBMs (day 4), only Ad-TK+GCV or Ad-FasL improved survival. In rats bearing large GBMs (day 9), the combination of Ad-Flt3L with Ad-FasL did not improve survival over FasL alone, while Ad-Flt3L combined with Ad-TK+GCV led to 70% long-term survival. Expression of FasL and TRAIL caused severe neuropathology, which was not encountered when we utilized Ad-TK+/−Ad-Flt3L. In vitro, all treatments elicit...

Full-text link

https://arrow.dit.ie/scschbioart/54

Dublin Institute of Technology

Journal article

unknown

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Investigation of response and resistance to dasatinib in melanoma cell lines (2010)

Eustace, Alexander J.

Dublin City University

Other

unknown

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Molecular basis for the therapeutic uses of botulinum toxin for chronic pain (2008)

Meng, Jianghui

Dublin City University

Other

unknown

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Expression of Genes Involved in a Radiation-Induced Bystander Effect (2011)

Furlong, Hayley

Dublin Institute of Technology

Conference item

unknown

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Numerical Simulations of in Vitro Nanoparticle Toxicity – the Case of Poly(amido amine) Dendrimers. (2014)

Maher, Marcus; Naha, Pratap; Mukherjee, Sourav Prasanna; Byrne, Hugh

Dublin Institute of Technology

Journal article

unknown

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The role of miRNAs in resistance to HER2 targeted therapies (2015)

Howe, Karen

Dublin City University

Other

unknown

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The Unc-5 Receptor Is Directly Regulated by Tinman in the Developing Drosophila Dorsal Vessel. (2015)

LABRADOR, JUAN

Trinity College Dublin

Journal article

peer-reviewed

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Identification of stiffness-induced signalling mechanisms in cells from patent and fused sutures associated with craniosynostosis. (2017)

Barreto, Sara; Gonzalez Vazquez, Arlyng; Cameron, Andrew R; O'Brien, Fergal J; Mur...

Royal College of Surgeons in Ireland

Journal article

peer-reviewed

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MiRNA-124-3p Reduces Cell Viability in Cisplatin Resistant Neuroblastoma Cell Models. (2017)

Nolan, John Christopher

Royal College of Surgeons in Ireland

Doctoral thesis

non-peer-reviewed

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BCL2 family proteins interactions as prognostic marker and determinants of therapy responses in breast cancer (2017)

Lucantoni, Federico

Royal College of Surgeons in Ireland

Doctoral thesis

non-peer-reviewed

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Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells. (2018)

Lucantoni, Federico; Lindner, Andreas U; O'Donovan, Norma; Düssmann, Heiko; Prehn,...

Royal College of Surgeons in Ireland

Journal article

peer-reviewed

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Autocatalytic closure and the evolution of cellular information processing networks (2009)

Decraene, James

Dublin City University

Other

unknown

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Chimerism in a Marine Protochordate (2002)

Sommerfeldt, Anna Dorothea

Dublin Institute of Technology

Other

unknown

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The Role of B2-glycoprotein I in Homeostatis (2007)

Lin, Frederic

Dublin Institute of Technology

Other

unknown

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Iron, Folate and Vitamin B12 Status of Apparently Healthy Irish Adult Women Attending General Practitioners in Inner-city Dublin (2002)

Casey, Helen R.

Dublin Institute of Technology

Other

unknown

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Hypoxia helps glioma to fight therapy (2009)

Amberger-Murphy, Verena

Dublin City University

Other

unknown

Mark

Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials. (2008)

Curtin, James; Candolfi, Marianela; Fakhouri, Tamer; Liu, Chunyan; Alden, Anderson; Edw...

Dublin Institute of Technology

Journal article

unknown

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HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression (2009)

Curtin, James; Liu, Naiyou; Candolfi, Marianela; Xiong, Weidong; Assi, Hikmat; Yagiz, K...

Dublin Institute of Technology

Journal article

unknown

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Turning the Gene Tap off; Implications of Regulating Gene Expression for Cancer Therapeutics (2008)

Curtin, James; Candolfi, Marianela; Xiong, Weidong; Lowenstein, Pedro; Castro, Maria

Dublin Institute of Technology

Review

unknown

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Isolation of cancer stem cells from adult glioblastoma multiforme (2004)

Yuan, Xianpeng; Curtin, James; Xiong, Yizhi; Liu, Gentao; Waschsmann-Hogiu, Sebastian; ...

Dublin Institute of Technology

Journal article

unknown

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Regulatable Gene Expression Systems for Gene Therapy Applications: Progress and Future Challenges (2005)

Goverdhana, Shyam; Puntel, Mariana; Xiong, Weidong; Zirger, Jeffrey; Barcia, Carlos; Cu...

Dublin Institute of Technology

Review

unknown

Mark

In Vivo Mature Immunological Synapses Forming SMACs Mediate Clearance of Virally Infected Astrocytes From the Brain (2006)

Barcia, Carlos; Thomas, Clare; Curtin, James; King, Gwendalyn; Wawrowsky, Kolja; Candol...

Dublin Institute of Technology

Journal article

unknown

Displaying Results 176 - 200 of 1609 on page 8 of 65

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