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Displaying Results 226 - 250 of 2028 on page 10 of 82

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The effect of temperature on hatch and activity of second-stage juveniles of the root-knot nematode, Meloidogyne minor, an emerging pest in north-west Europe (2011)

Morris, Karen S.; Horgan, Finbarr G.; Downes, Martin; Griffin, Christine

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Cross-taxa congruence, indicators and environmental gradients in soils under agricultural and extensive land management (2012)

Keith, Aidan M.; Boots, Bas; Hazard, Christina; Niechoj, Robin; Arroyo, Julio; Bending,...

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The Role of Glutathione S-Transferase GliG in Gliotoxin Biosynthesis in Aspergillus fumigatus (2011)

Davis, Carol; Carberry, Stephen; Schrettl, Markus; Singh, Ishwar ; Stephens, John C.; B...

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Simulation of biopsy bevel-tipped needle insertion into soft-gel (2019)

Jushiddi, Mohamed Gouse; Mulvihill, John J.E.; Chovan, Drahomir; Mani, Aladin; Shanahan...

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Multiple pathways involved in palmitic acid-induced toxicity: a system biology approach (2020)

Osorio, Daniel; Pinzón, Andrés; Martín-Jiménez, Cynthia; Barreto, George E.; González, ...

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HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity (2015)

Saeedi, Bejan J.; Kao, Daniel J.; Kitzenberg, D.A.; Dobrinskikh, Evgenia; Schwisow, Kay...

HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity (2015)

Saeedi, Bejan J.; Kao, Daniel J.; Kitzenberg, D.A.; Dobrinskikh, Evgenia; Schwisow, Kayla D.; Masterson, Joanne C.; Kendrick, Agnieszka A.; Kelly, Caleb J.; Bayless, A.; Kominsky, Douglas J.; Campbell, Eric L.; Kuhn, Kristine A.; Furuta, Glenn T.; Colgan, S.P.; Glover, Louise

Abstract:

Intestinal epithelial cells (IECs) are exposed to profound fluctuations in oxygen tension and have evolved adaptive transcriptional responses to a low-oxygen environment. These adaptations are mediated primarily through the hypoxia-inducible factor (HIF) complex. Given the central role of the IEC in barrier function, we sought to determine whether HIF influenced epithelial tight junction (TJ) structure and function. Initial studies revealed that short hairpin RNA–mediated depletion of the HIF1β in T84 cells resulted in profound defects in barrier and nonuniform, undulating TJ morphology. Global HIF1α chromatin immunoprecipitation (ChIP) analysis identified claudin-1 (CLDN1) as a prominent HIF target gene. Analysis of HIF1β-deficient IEC revealed significantly reduced levels of CLDN1. Overexpression of CLDN1 in HIF1β-deficient cells resulted in resolution of morphological abnormalities and restoration of barrier function. ChIP and site-directed mutagenesis revealed prominent hypoxia ...

http://mural.maynoothuniversity.ie/12486/

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Eosinophils, probiotics, and the microbiome (2016)

Rosenberg, Helene F.; Masterson, Joanne C.; Furuta, Glenn T.

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More Than a Repair Enzyme: Aspergillus nidulans Photolyase-like CryA Is a Regulator of Sexual Development (2008)

Bayram, Ozgur; Biesemann, Christoph; Krappmann, Sven; Galland, Paul; Braus, Gerhard H.

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Autophagy mediates epithelial cytoprotection in Eosinophilic Oesophagitis (2017)

Whelan, Kelly A.; Merves, Jamie F.; Giroux, Veronique; Tanaka, Koji; Guo, Andy; Chandra...

Autophagy mediates epithelial cytoprotection in Eosinophilic Oesophagitis (2017)

Whelan, Kelly A.; Merves, Jamie F.; Giroux, Veronique; Tanaka, Koji; Guo, Andy; Chandramouleeswaran, Prasanna M.; Benitez, Benitez; Dods, Kara; Que, Jianwen; Masterson, Joanne C.; Fernando, Shahan D.; Godwin, Bridget C.; Klein-Szanto, Andres J.; Chikwava, Kudakwashe; Ruchelli, Eduardo D.; Hamilton, Kathryn E.; Muir, Amanda B.; Wang, Mei-Lun; Furuta, Glenn T.; Falk, Gary W.

Abstract:

Objective—The influence of eosinophilic oesophagitis (EoE)-associated inflammation upon oesophageal epithelial biology remains poorly understood. We investigated the functional role of autophagy in oesophageal epithelial cells (keratinocytes) exposed to the inflammatory EoE milieu. Design—Functional consequences of genetic or pharmacological autophagy inhibition were assessed in endoscopic oesophageal biopsies, human oesophageal keratinocytes, single cell-derived ex vivo murine oesophageal organoids as well as a murine model recapitulating EoE-like inflammation and basal cell hyperplasia. Gene expression, morphological and functional characterization of autophagy and oxidative stress were performed by transmission electron microscopy, immunostaining, immunoblotting, live cell imaging and flow cytometry. Results—EoE-relevant inflammatory conditions promoted autophagy and basal cell hyperplasia in three independent murine EoE models and oesophageal organoids. Inhibition of autophagic ...

http://mural.maynoothuniversity.ie/11827/

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Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-α responses (2014)

Collins, Aideen S.; Ahmed, Suaad; Napoletano, Silvia; Schroeder, Martina; Johnston, Jam...

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NK cells regulate CXCR2+ neutrophil recruitment during acute lung injury (2017)

Hoegl, Sandra; Ehrentraut, Heidi; Brodsky, Kelley S.; Victorino, Francisco; Golden‐Maso...

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Nuclear Factor κB2 p52 Protein Has a Role in Antiviral Immunity through IκB Kinase ϵ-dependent Induction of Sp1 Protein and Interleukin 15 (2013)

Doyle, Sarah L.; Shirey, Kari Ann; McGettrick, Anne F.; Kenny, Elaine F.; Carpenter, Su...

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Environmental stress resistance: Selection in plant cell cultures. (1980)

Dix, Philip

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Antibiotic resistance in Nicotiana. (1980)

Maliga, Pal; Xuan, Le Thi; Dix, Philip; Cseplo, Agnes

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Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines (2003)

Dalton, John P.; O'Neill, Sandra M.; Stack, Colin M.; Collins, Peter R.; Walshe, A...

Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines (2003)

Dalton, John P.; O'Neill, Sandra M.; Stack, Colin M.; Collins, Peter R.; Walshe, Alan; Sekiya, Mary; Doyle, Sean; Mulcahy, Grace; Hoyle, Deborah; Khaznadji, Eric; Moire, Nathalie; Brennan, Gerard; Mousley, Angela; Kreshchenko, Natalia; Maule, Aaron G.; Donnelly, Sheila M.

Abstract:

Fasciola hepatica secretes cathepsin L proteases that facilitate the penetration of the parasite through the tissues of its host, and also participate in functions such as feeding and immune evasion. The major proteases, cathepsin L1 (FheCL1) and cathepsin L2 (FheCL2) are members of a lineage that gave rise to the human cathepsin Ls, Ks and Ss, but while they exhibit similarities in their substrate specificities to these enzymes they differ in having a wider pH range for activity and an enhanced stability at neutral pH. There are presently 13 Fasciola cathepsin L cDNAs deposited in the public databases representing a gene family of at least seven distinct members, although the temporal and spatial expression of each of these members in the developmental stage of F. hepatica remains unclear. Immunolocalisation and in situ hybridisation studies, using antibody and DNA probes, respectively, show that the vast majority of cathepsin L gene expression is carried out in the epithelial cell...

http://mural.maynoothuniversity.ie/7404/

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The Relation between the What-It-Is and the Why-It-Is in Aristotle's Posterior Analytics, On the Parts of Animals, and Metaphysics (2020)

GE, TIANQIN

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A rational computer-aided drug discovery approach to target IRE1 and PERK: Insights into structural dynamics and selectivity (2020)

Chintha, Chetan

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Teacher Design Teams (TDTs) - building capacity for innovation, learning and curriculum implementation in the continuing professional development of in-career teachers (2007)

Mooney Simmie, Geraldine

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Potential of Vibrational Spectroscopy in the Diagnosis of Human Tumours. (2006)

O'Faolain, Eoghan

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Tinman Regulates NetrinB in the Cardioblasts of the Drosophila Dorsal Vessel. (2016)

LABRADOR, JUAN

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Applying quantitative methods to conservation planning : Population dynamics of the Eurasian otter in Ireland (2008)

? N?ill, Lughaidh

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The role of Notch1 Receptor N-glycosylation in the transition of stem cells to vascular smooth muscle cells (2018)

Olayinka, Abidemi

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Young people's perspectives on genetics, identity and society using film and discussion (2005)

Murphy, Padraig

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Biomarkers for Placental Abnormality (2005)

McCarthy, Cathal

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Release of HMGB1 in Response to Pro-Apoptotic Glioma Killing Strategies: Efficacy and Neurotoxicity (2010)

Candolfi, Marianela; Yagiz, Kader; Foulad, David; Alzadeh, Gabrielle; Tesarfreund, Matt...

Release of HMGB1 in Response to Pro-Apoptotic Glioma Killing Strategies: Efficacy and Neurotoxicity (2010)

Candolfi, Marianela; Yagiz, Kader; Foulad, David; Alzadeh, Gabrielle; Tesarfreund, Matthew; Muhammad, AKM Ghulam; Puntel, Mariana; Kroeger, Kurt; Liu, Chunyan; Lee, Sharon; Curtin, James; King, Gwendalyn D; Lerner, Jonathan; Sato, Katsuaki; Mineharu, Yohei; Xiong, Weidong; Lowenstein, Pedro R; Castro, Maria

Abstract:

Purpose In preparation for a Phase I clinical trial utilizing a combined cytotoxic/immunotherapeutic strategy using adenoviruses expressing Flt3L (Ad-Flt3L) and thymidine kinase (Ad-TK) to treat glioblastoma (GBM), we tested the hypothesis that Ad-TK+GCV would be the optimal tumor killing agent in relation to efficacy and safety when compared to other pro-apoptotic approaches. Experimental Design and Results The efficacy and neurotoxicity of Ad-TK+GCV was compared with Ads encoding the pro-apoptotic cytokines (TNF-α, TRAIL, FasL), alone or in combination with Ad-Flt3L. In rats bearing small GBMs (day 4), only Ad-TK+GCV or Ad-FasL improved survival. In rats bearing large GBMs (day 9), the combination of Ad-Flt3L with Ad-FasL did not improve survival over FasL alone, while Ad-Flt3L combined with Ad-TK+GCV led to 70% long-term survival. Expression of FasL and TRAIL caused severe neuropathology, which was not encountered when we utilized Ad-TK+/−Ad-Flt3L. In vitro, all treatments elicit...

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