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Displaying Results 11701 - 11725 of 11754 on page 469 of 471
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Automated Decontamination of Multiple Washbasin U-bends in a Hospital Setting Using Electrochemically Activated Solutions: Exploring the Role U-bends and the Wastewater Network Plays in the Trafficking of Potentially Pathogenic Bacteria in a Healthcare Facility
(2020)
MOLONEY, ELAINE MARY
Automated Decontamination of Multiple Washbasin U-bends in a Hospital Setting Using Electrochemically Activated Solutions: Exploring the Role U-bends and the Wastewater Network Plays in the Trafficking of Potentially Pathogenic Bacteria in a Healthcare Facility
(2020)
MOLONEY, ELAINE MARY
Abstract:
Hand washing is a vital component of any hand hygiene strategy, essential for reducing nosocomial infections. Paradoxically, hand washbasins have been identified as reservoirs and disseminators of infection. Washbasin U-bends are pipe fixtures located directly below the drain outlet designed to retain water that acts as a seal preventing gases entering buildings from wastewater pipes. However, frequently stagnation of this water facilitates biofilm formation. All previous approaches to decontaminating U-bends have been ineffective in the long-term, potentially hazardous to staff, toxic to the environment and/or incur high running costs. The primary aim of this thesis was to develop an automated system for simultaneously decontaminating multiple washbasin U-bends and associated proximal wastewater pipes in the Dublin Dental University Hospital (DDUH) Accident & Emergency Department (A&E) by sequential treatment with electrochemically activated solutions (ECAs) generated from ...
http://hdl.handle.net/2262/94443
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Highly charged 180 degree head-to-head domain walls in lead titanate
(2020)
Moore, Kalani; Conroy, Michele; O'Connell, Eoghan N.; Cochard, Charlotte; Mackel, ...
Highly charged 180 degree head-to-head domain walls in lead titanate
(2020)
Moore, Kalani; Conroy, Michele; O'Connell, Eoghan N.; Cochard, Charlotte; Mackel, Jennifer; Harvey, Alan; Hooper, Thomas E.; Bell, Andrew J.; Gregg, J. Marty; Bangert, Ursel
Abstract:
Charged domain walls (DWs) in ferroelectric materials are an area of intense research. Microscale strain has been identified as a method of inducing arrays of twin walls to meet at right angles, forming needlepoint domains which exhibit novel material properties. Atomic scale characterisation of the features exhibiting these exciting behaviours was inaccessible with the piezoresponse force microscopy resolution of previous work. Here we use aberration corrected scanning transmission electron microscopy to observe short, stepped, highly charged DWs at the tip of the needle points in ferroelectric PbTiO3. Reverse Ti4+ shift polarisation mapping confirms the head-to-head polarisation in adjacent domains. Strain mapping reveals large deviations from the bulk and a wider DW with a high Pb2+ vacancy concentration. The extra screening charge is found to stabilise the DW perpendicular to the opposing polarisation vectors and thus constitutes the most highly charged DW possible in PbTiO3. Th...
http://hdl.handle.net/10344/9545
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Optimizing a digital intervention for managing blood pressure in stroke patients using a diverse sample: Integrating the person-based approach and patient and public involvement
(2020)
Rai, Tanvi; Morton, Kate; Roman, Cristian; Doogue, Róisín; Rice, Cathy; Williams, Marne...
Optimizing a digital intervention for managing blood pressure in stroke patients using a diverse sample: Integrating the person-based approach and patient and public involvement
(2020)
Rai, Tanvi; Morton, Kate; Roman, Cristian; Doogue, Róisín; Rice, Cathy; Williams, Marney; Schwartz, Claire; Velardo, Carmelo; Tarassenko, Lionel; Yardley, Lucy; McManus, Richard J.; Hinton, Lisa
Abstract:
Background: Having a stroke or transient ischaemic attack increases the risk of a subsequent one, especially with high blood pressure (BP). Home-based BP management can be effective at maintaining optimal BP. Objective: To describe the optimization of a digital intervention for stroke patients and the value of participant diversity, using the person-based approach (PBA) and integral patient and public involvement (PPI). Setting and participants: Stroke patients recruited from primary care and community settings, and health-care professionals in primary care, in England and Ireland. Design: Three linked qualitative studies conducted iteratively to develop an intervention using the PBA, with integral PPI. Intervention: The BP: Together intervention, adapted from existing BP self-monitoring interventions, is delivered via mobile phone or web interface to support selfmonitoring of BP at home. It alerts patients and their clinicians when a change in antihypertensive medication is needed....
http://hdl.handle.net/10344/9546
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The interactions of apolipoprotein E and inflammation in human iPSC-derived astrocytes
(2020)
MC COMISH, SARAH FRANCES
The interactions of apolipoprotein E and inflammation in human iPSC-derived astrocytes
(2020)
MC COMISH, SARAH FRANCES
Abstract:
Alzheimer?s disease (AD) is a devastating neurodegenerative disease characterised histologically by the presence of extracellular plaques and intracellular neurofibrillary tangles, and clinically by memory loss, cognitive decline and personality changes. Much of the research investigating AD to date has focused on the familial early-onset form of AD which accounts for <5% of cases. Most cases are sporadic with late-onset, with certain genes presenting a high risk. Apolipoprotein E (APOE) genotype is one of the major genetic risk factors for late-onset AD. There are three major APOE isoforms (APOE2, APOE3and APOE4), each differing by a single amino acid residueat the protein leveland thus inferring different AD-risk. APOE2 contains cysteineat amino acid residues 112 and 158, APOE3contains a cysteine at residue 112 and arginine at residue 158, while APOE4 contains arginine at both residue sites.APOE3 is most common in the general population and ...
http://hdl.handle.net/2262/94468
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Quantification of residual stress governing the spin-reorientation transition (SRT) in amorphous magnetic thin films
(2020)
Cronin, Darragh; Hardiman, M.; Lordan, Daniel; Wei, Guannan; McCloskey, Paul; O'Ma...
Quantification of residual stress governing the spin-reorientation transition (SRT) in amorphous magnetic thin films
(2020)
Cronin, Darragh; Hardiman, M.; Lordan, Daniel; Wei, Guannan; McCloskey, Paul; O'Mathúna, Cian; Masood, Ansar
Abstract:
Soft magnetic thin films with in-plane uniaxial magnetic anisotropy are of significant importance for a broad range of technological applications, including high-frequency power conversion. In-plane uniaxial anisotropy in amorphous films is of particular interest for ultra-low materials loss and MHz frequency operations. The present work is focused on one of the fundamental mechanisms, i.e., residual stress, that can negate the uniaxial anisotropy in amorphous films by engendering perpendicular magnetisation and hence, undermining the soft magnetic performance. It is quantified how the nature of residual stress, compressive or tensile, transforms the magnetisation from an in-plane to an out-of-plane configuration, also well-known as spin-reorientation transition (SRT). A correlation between engineered residual stress in multilayer stacks, induced by the uneven expansion of metallic/dielectric layers following a thermal-shock scheme, and SRT mechanism demonstrates tensile stress insi...
http://hdl.handle.net/10468/10850
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Tapered nonlinear vibration energy harvester for powering Internet of Things
(2020)
Paul, Kankana; Amann, Andreas; Roy, Saibal
Tapered nonlinear vibration energy harvester for powering Internet of Things
(2020)
Paul, Kankana; Amann, Andreas; Roy, Saibal
Abstract:
The lack of a sustainable power source to substitute batteries for long-term applications limits the widespread deployment of wireless sensor nodes in this era of the Internet of Things. Conventional linear Vibration Energy Harvesters are inefficient in converting ambient mechanical energy into usable electrical energy owing to their narrow frequency bandwidth when harnessing mechanical energy that is spread over a wide range of frequencies. In this work, we design, develop and demonstrate high power density nonlinear wideband energy harvesters using novel tapered spring architectures in an autonomous wireless sensor node system. These spring structures exhibit a nonlinear restoring force arising from the atypical stress distribution that can be additionally tuned by changing the taper-ratio in the structure. We investigate different tapering designs in order to achieve optimal spring hardening nonlinearities. This nonlinearity aids in widening the operable bandwidth, making the har...
http://hdl.handle.net/10468/10851
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Teaching topographic map skills and geomorphology concepts with Google Earth in a one-computer classroom
(2018)
Hsu, Hsiao-Ping; Tsai, Bor-Wen; Chen, Che-Ming
Teaching topographic map skills and geomorphology concepts with Google Earth in a one-computer classroom
(2018)
Hsu, Hsiao-Ping; Tsai, Bor-Wen; Chen, Che-Ming
Abstract:
Teaching high-school geomorphological concepts and topographic map reading entails many challenges. This research reports the applicability and effectiveness of Google Earth in teaching topographic map skills and geomorphological concepts, by a single teacher, in a one-computer classroom. Compared to learning via a conventional instructional method, students learning with Google Earth do not have different geomorphological concepts development because both settings enable students to learn with similar static representation. However, students learning with Google Earth improve topographic map skills significantly compared to the conventional instructional method. This is because of the 3D landscape visualization and prior knowledge connections available with Google Earth.
http://doras.dcu.ie/25278/
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Rectangular to Large Diameter Conical Corrugated Waveguide Converter Based on Stacked Rings
(2015)
Doherty, Stephen; von Bieren, Arndt; Cahill, Fiachra; Macor, Alessandro; de Rijk, Emile...
Rectangular to Large Diameter Conical Corrugated Waveguide Converter Based on Stacked Rings
(2015)
Doherty, Stephen; von Bieren, Arndt; Cahill, Fiachra; Macor, Alessandro; de Rijk, Emile; Trappe, Neil; Billod, Mathieu; O'Sullivan, Créidhe; Favre, Mirko; Gradziel, Marcin; Murphy, J.Anthony
Abstract:
This paper considers the design and manufacture, using stacked rings, of a standard corrugated antenna for the WM-380 band for use as a converter from a WM-380 rectangular aperture to a large diameter conical corrugated waveguide. In-house mode matching software is utilised for the design and three prototypes manufactured using stacked rings. The level of agreement of the stacked ring prototypes with the design predictions for the return loss and HE11 modal coupling is measured and found to demonstrate high levels of agreement.
http://mural.maynoothuniversity.ie/13773/
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SV40 T antigen interactions with ssDNA and replication protein A: a regulatory role of T antigen monomers in lagging strand DNA replication
(2021)
Onwubiko, Nichodemus O.; Borst, Angela; Diaz, Suraya A.; Passkowski, Katharina; Scheffe...
SV40 T antigen interactions with ssDNA and replication protein A: a regulatory role of T antigen monomers in lagging strand DNA replication
(2021)
Onwubiko, Nichodemus O.; Borst, Angela; Diaz, Suraya A.; Passkowski, Katharina; Scheffel, Felicia; Tessmer, Ingrid; Nasheuer, Heinz-Peter
Abstract:
DNA replication is a central process in all living organisms. Polyomavirus DNA replication serves as a model system for eukaryotic DNA replication and has considerably contributed to our understanding of basic replication mechanisms. However, the details of the involved processes are still unclear, in particular regarding lagging strand synthesis. To delineate the complex mechanism of coordination of various cellular proteins binding simultaneously or consecutively to DNA to initiate replication, we investigated single-stranded DNA (ssDNA) interactions by the SV40 large T antigen (Tag). Using single molecule imaging by atomic force microscopy (AFM) combined with biochemical and spectroscopic analyses we reveal independent activity of monomeric and oligomeric Tag in high affinity binding to ssDNA. Depending on ssDNA length, we obtain dissociation constants for Tag-ssDNA interactions (K-D values of 10-30 nM) that are in the same order of magnitude as ssDNA binding by human replication...
http://hdl.handle.net/10379/16400
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Polarization Calibration of the QUaD Experiment
(2011)
Hinderks, J.; Ade, P.A.R.; Bock, J.J.; Bowden, M.; Brown, M.L.; Cahill, G.; Carlstrom, ...
Polarization Calibration of the QUaD Experiment
(2011)
Hinderks, J.; Ade, P.A.R.; Bock, J.J.; Bowden, M.; Brown, M.L.; Cahill, G.; Carlstrom, J.E.; Castro, P.G.; Church, S.; Culverhouse, T.; Friedman, R.; Ganga, K.; Gear, W.K.; Gupta, S.; Harris, J.; Haynes, V.; Kovac, J.; Lange, A.E.; Leitch, E.; Mallie, O.E.
Abstract:
We describe the polarization calibration of the QUaD experiment, including determination of the polarization efficiency of the detectors and their orientation angles. QUaD is a millimeter-wavelength polarimeter that observed the Cosmic Microwave Background (CMB) from a site at the South Pole. The experiment comprises a 2.64 m Cassegrain telescope equipped with a cryogenically cooled receiver containing an array of 62 polarization-sensitive bolometers. The focal plane contains pixels at two different frequency bands, 100 GHz and 150 GHz, with angular resolutions of 5prime and 3farcm5, respectively. The high angular resolution allows observation of CMB temperature and polarization anisotropies over a wide range of scales. The instrument commenced operation in early 2005 and collected science data during three successive Austral winter seasons of observation.
http://mural.maynoothuniversity.ie/13778/
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Planck-HFI optical design and pre-flight performances
(2010)
Maffei, B.; Noviello, F.; Savini, G.; Murphy, J.Anthony; Lamarre, J.-M.; Ade, P.A.R.; B...
Planck-HFI optical design and pre-flight performances
(2010)
Maffei, B.; Noviello, F.; Savini, G.; Murphy, J.Anthony; Lamarre, J.-M.; Ade, P.A.R.; Bouchet, F.R.; Brossard, J.; Catalano, A.; Colgan, R.; Gispert, R.; Gleeson, E.; Haynes, C.V.; Jones, W.C.; Lange, A.E.; Longval, Y.; McAuley, I.; Norgaard-Nielsen, H.U.; Pajot, F.; Peacocke, T.
Abstract:
Planck is a European Space Agency (ESA) satellite, launched in May 2009, which is mapping the Cosmic Microwave Background anisotropies in intensity and polarisation with unprecedented detail and sensitivity. It will also provide full-sky maps of astrophysical foregrounds. An accurate knowledge of the telescope beam patterns is an essential element for a correct analysis of the acquired astrophysical data. We present the optical design of the High Frequency Instrument (HFI) together with the optical performances measured during the ground calibration campaigns. We report on the evolution of the knowledge of the pre-launch HFI beam patterns when coupled to the telescope, and on their significance for the HFI data analysis procedure.
http://mural.maynoothuniversity.ie/13779/
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Electromagnetic modelling of few-moded Winston cones in the far-infrared
(2002)
Gleeson, E.; Murphy, J.Anthony; Church, S.E.; Colgan, R.; O'Sullivan, Créidhe
Electromagnetic modelling of few-moded Winston cones in the far-infrared
(2002)
Gleeson, E.; Murphy, J.Anthony; Church, S.E.; Colgan, R.; O'Sullivan, Créidhe
Abstract:
Winston cones have traditionally been used as detector feeds in far-infrared cosmological experiments, such as SuZIe, the Sunyaev-Zel’dovich Infra-red Experiment [1] on the CSO. They are usually designed using ray tracing, which becomes a very poor approximation when the number of spatial modes propagated by the horn is small in number, often the case at the longest wavelengths. We describe a more accurate approach involving electromagnetic modelling of Winston cones using a rigorous electromagnetic mode matching technique. It is straightforward to also consider the case of few-moded corrugated Winston cones, which offer lower sidelobe levels than smooth walled cones which is important for high sensitivity experiments. Furthermore, the mode matching technique allows more complex structures such as back-to-back Winston cones and the detector cavities to also be analyzed.
http://mural.maynoothuniversity.ie/13782/
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Impact of ergothioneine, hercynine, and histidine on oxidative degradation of hyaluronan and wound Healing
(2021)
Valachova, Katarina; Svik, Karol; Biro, Csaba; Collins, Maurice N.; Jurcik, Rastislav; ...
Impact of ergothioneine, hercynine, and histidine on oxidative degradation of hyaluronan and wound Healing
(2021)
Valachova, Katarina; Svik, Karol; Biro, Csaba; Collins, Maurice N.; Jurcik, Rastislav; Ondruska, Lubomir; Soltes, Ladislav
Abstract:
A high-molecular weight hyaluronan is oxidatively degraded by Cu(II) ions and ascorbate—the so called Weissberger biogenic oxidative system—which is one of the most potent generators of reactive oxygen species, namely •OH radicals. Ergothioneine, hercynine, or histidine were loaded into chitosan/hyaluronan composite membranes to examine their effect on skin wound healing in ischemic rabbits. We also explored the ability of ergothioneine, hercynine, or histidine to inhibit hyaluronan degradation. Rotational viscometry showed that ergothioneine decreased the degree of hyaluronan radical degradation in a dose-dependent manner. While histidine was shown to be potent in scavenging •OH radicals, however, hercynine was ineffective. In vivo results showed that the addition of each investigated agent to chitosan/hyaluronan membranes contributed to a more potent treatment of ischemic skin wounds in rabbits compared to untreated animals and animals treated only with chitosan/hyaluronan membranes.
http://hdl.handle.net/10344/9557
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Increased weight gain during the long interdialytic period Is associated with minor effects on blood pressure control in clinically stable in-centre haemodialysis patients
(2021)
Shantier, Mohamed; Martin, William P.; Singh, Rajneet; McDermott, Paul; Gallen, Rory; S...
Increased weight gain during the long interdialytic period Is associated with minor effects on blood pressure control in clinically stable in-centre haemodialysis patients
(2021)
Shantier, Mohamed; Martin, William P.; Singh, Rajneet; McDermott, Paul; Gallen, Rory; Suleiman, Sami; Reddan, Donal N.; Giblin, Louise; Lappin, David; O’Meara, Yvonne M.; Griffin, Matthew D.
Abstract:
Background/Aims: Three-day-a-week chronic haemodialysis (cHD) involves 1 long (72 h) and 2 short (48 h) inter-dialytic periods (IDPs), We aimed to determine whether BP control following the long IDP is inferior to the short IDPs. Methods: All pre- and post-dialysis BP and weight measurements over a 4-week period were retrospectively analyzed among 135 clinically stable cHD patients at 2 academic centres with comparisons between measurements recorded following short and long IDPs. Subsequently, 23 clinically stable cHD patients underwent 24-h ambulatory blood pressure monitoring (ABPM) during the final day/night cycle of the long IDP and 1 short IDP within the same week. Results: In combined and separate analyses of the 2 retrospective cohorts, pre-dialysis BP parameters were not different following long and short IDPs despite greater inter-dialytic weight gain (IDWG) during the long IDP. Subgroup analyses of the total cohort showed no evidence for inferior BP control during the long...
http://hdl.handle.net/10379/16406
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Crystallization of organic salts from the gas phase: When does proton transfer take place?
(2021)
O’Malley, Ciarán; Erxleben, Andrea; McArdle, Patrick; Simmie, John M.
Crystallization of organic salts from the gas phase: When does proton transfer take place?
(2021)
O’Malley, Ciarán; Erxleben, Andrea; McArdle, Patrick; Simmie, John M.
Abstract:
Salt formation with proton transfer is observed in crystals grown by cosublimation of the salt coformers. Diflunisal salts were obtained with 4-[3-(pyridin-4-yl)propyl]pyridine, piperazine, and 4-dimethylaminopyridine. Modeling studies indicate that proton transfer does not take place for an acid–base H-bonded adduct in the gas phase. However, modeling larger molecular clusters shows that proton transfer can take place spontaneously within a molecular cluster in the absence of a solvent.
This publication has emanated from research supported in part by a research grant from Science Foundation Ireland (SFI) and is co-funded under the European Regional Development Fund under Grant Number 12/RC/2275-P2. JMS thanks the Irish Centre for High-End Computing (ICHEC, project ngche071b) for the provision of resources.
2021-12-13
http://hdl.handle.net/10379/16409
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Studies on downstream migrating silver-phase European eels (Anguilla anguilla) in hydropower-regulated rivers
(2021)
Lenihan, Eamonn
Studies on downstream migrating silver-phase European eels (Anguilla anguilla) in hydropower-regulated rivers
(2021)
Lenihan, Eamonn
Abstract:
Within the last 50 years, the European eel has gone from one of the largest freshwater fisheries resources throughout its range to being listed as critically endangered. A variety of factors have been implicated in this decline, but the exact causes remain poorly understood. However, during their downstream spawning migrations from rivers and lakes to the ocean, silver eels are exposed to considerable interference from in-channel structures and the biomass of eels successfully escaping from European rivers has greatly diminished. As a result of this decline, the European Union introduced Regulation EC No. 1100/2007. The key goal of this regulation is to enable, with a high probability, the escapement to the sea of at least 40% of the silver eel biomass that would exist under pristine conditions. All Member States with natural eel habitats were required to establish eel management plans (EMPs) that outlined measures to reduce anthropogenic mortality and to develop monitoring programm...
http://hdl.handle.net/10379/16402
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Layered double hydroxide as a potent non-viral vector for nucleic acid delivery using gene-activated scaffolds for tissue regeneration applications
(2020)
Nicolosi, Valeria
Layered double hydroxide as a potent non-viral vector for nucleic acid delivery using gene-activated scaffolds for tissue regeneration applications
(2020)
Nicolosi, Valeria
Abstract:
Nonviral vectors offer a safe alternative to viral vectors for gene therapy applications, albeit typically exhibiting lower transfection efficiencies. As a result, there remains a significant need for the development of a nonviral delivery system with low cytotoxicity and high transfection efficacy as a tool for safe and transient gene delivery. This study assesses MgAl-NO3 layered double hydroxide (LDH) as a nonviral vector to deliver nucleic acids (pDNA, miRNA and siRNA) to mesenchymal stromal cells (MSCs) in 2D culture and using a 3D tissue engineering scaffold approach. Nanoparticles were formulated by complexing LDH with pDNA, microRNA (miRNA) mimics and inhibitors, and siRNA at varying mass ratios of LDH:nucleic acid. In 2D monolayer, pDNA delivery demonstrated significant cytotoxicity issues, and low cellular transfection was deemed to be a result of the poor physicochemical properties of the LDH?pDNA nanoparticles. However, the lower mass ratios required to successfully comp...
http://hdl.handle.net/2262/94556
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Improving stability of organometallic-halide perovskite solar cells using exfoliation two-dimensional molybdenum chalcogenides
(2020)
Nicolosi, Valeria; Sanvito, Stefano
Improving stability of organometallic-halide perovskite solar cells using exfoliation two-dimensional molybdenum chalcogenides
(2020)
Nicolosi, Valeria; Sanvito, Stefano
Abstract:
Organometallic-halide perovskite solar cells (PSCs) are emerging as the most promising next generation solar cell devices. However, the stability is still the main bottleneck of their further development. Here, we introduce two-dimensional (2D) molybdenum chalcogenides (MoS 2 and MoSe 2 ) (MCs) nanoflakes as a buffer layer between perovskite layer and hole transport layer (HTL) to improve the stability of the organometallic-halide PSCs. 2D MCs are obtained via liquid-phase exfoliated (LPE) approach, and Glass/FTO/compact-TiO 2 / mesoporous-TiO 2 /FA 85 MA 15 PbI 85 Br 15 /2D MCs/Spiro-OMeTAD/Au structured solar cell devices are designed and fabricated. In this system, 2D MCs act both as a protective layer and an additional HTL of PSCs. This kind of PSCs achieve a relatively high-power conversion efficiency (PCE) of 14.9%, along with a much longer lifetime stability compared to the standard PSCs. After 1?h, PCE of the PSC adding a 2D MCs buffer layer could maintain 93.1% of initial v...
http://hdl.handle.net/2262/94555
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Characterisation of the efficacy of two novel host-directed therapies, SCD-19 and 4-octyl itaconate, for the treatment of Pseudomonas aeruginosa infection in cystic fibrosis.
(2021)
O'NEILL, ANDREW
Characterisation of the efficacy of two novel host-directed therapies, SCD-19 and 4-octyl itaconate, for the treatment of Pseudomonas aeruginosa infection in cystic fibrosis.
(2021)
O'NEILL, ANDREW
Abstract:
Cystic Fibrosis (CF) is a life limiting genetic disease, which is caused by genetic mutations which result in defective function of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). In CF, patients experience frequent hospitalisations from a young age as a result of recurrent respiratory infections and inflammatory lung damage, with CF patients having a median life expectancy of only 31 years. Therefore, currently there is an urgent unmet clinical need for the development of novel anti-inflammatory and antibacterial therapies in the treatment of CF. Within the CF lung, the build-up of thick mucus secretions provides a microenvironment which is conducive to bacterial colonisation and inflammation. Pseudomonas aeruginosa (P. aeruginosa) is the most commonly isolated pathogen from the CF lung. CF patients develop a series of recurrent, intermittent colonisations of P. aeruginosa before the acquisition of a biofilm-driven chronic infection. The establishment of a chronic ...
http://hdl.handle.net/2262/94560
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Quantifying used electrical and electronic equipment exported from ireland to west africa in roll-on roll-off vehicles
(2021)
McMahon, Kathleen; Uchendu, Chidinma; Fitzpatrick, Colin
Quantifying used electrical and electronic equipment exported from ireland to west africa in roll-on roll-off vehicles
(2021)
McMahon, Kathleen; Uchendu, Chidinma; Fitzpatrick, Colin
Abstract:
The investigation on the transboundary shipment of used and waste electrical and electronic equipment from developed countries is a well-studied subject with regard to the environmental and health impacts in the destination countries when it reaches end-of-life. Prior research has ranked Ireland the 8th highest source of used electrical and electronic equipment (UEEE) into Nigeria, with roll-on roll-off (RoRo) vehicles as the largest carrier (Odeyingbo 2017). This study presents the first comprehensive port of origin estimation of UEEE export shipments from Ireland in RoRo vehicles. This was obtained by using a ‘person in the port’ involving vehicle and enforcement document inspections at the Ringaskiddy port in Cork, Ireland. By scaling sampling data to annual shipment figures, it was estimated that 17,319 kg of UEEE are currently exported from Ireland annually and that around 1 in 5 vehicles exported contain UEEE. Additionally, the type of UEEE and frequency of shipments show cert...
http://hdl.handle.net/10344/9565
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A population of proinflammatory T cells coexpresses ?? and ?? T cell receptors in mice and humans
(2020)
Mills, Kingston; Moran, Barry
A population of proinflammatory T cells coexpresses ?? and ?? T cell receptors in mice and humans
(2020)
Mills, Kingston; Moran, Barry
Abstract:
T cells are classically recognized as distinct subsets that express ?? or ?? TCRs. We identify a novel population of T cells that coexpress ?? and ?? TCRs in mice and humans. These hybrid ??-?? T cells arose in the murine fetal thymus by day 16 of ontogeny, underwent ?? TCR?mediated positive selection into CD4+ or CD8+ thymocytes, and constituted up to 10% of TCR?+ cells in lymphoid organs. They expressed high levels of IL-1R1 and IL-23R and secreted IFN-?, IL-17, and GM-CSF in response to canonically restricted peptide antigens or stimulation with IL-1? and IL-23. Hybrid ??-?? T cells were transcriptomically distinct from conventional ?? T cells and displayed a hyperinflammatory phenotype enriched for chemokine receptors and homing molecules that facilitate migration to sites of inflammation. These proinflammatory T cells promoted bacterial clearance after infection with Staphylococcus aureus and, by licensing encephalitogenic Th17 cells, played a key role in the development of aut...
http://hdl.handle.net/2262/94573
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Mechanochromic and Thermochromic Sensors Based on Graphene Infused Polymer Opals
(2020)
Coleman, Jonathan
Mechanochromic and Thermochromic Sensors Based on Graphene Infused Polymer Opals
(2020)
Coleman, Jonathan
Abstract:
High quality opal-like photonic crystals containing graphene are fabricated using evaporation-driven self-assembly of soft polymer colloids. A miniscule amount of pristine graphene within a colloidal crystal lattice results in the formation of colloidal crystals with a strong angle-dependent structural color and a stop band that can be reversibly shifted across the visible spectrum. The crystals can be mechanically deformed or can reversibly change color as a function of their tem- perature, hence their sensitive mechanochromic and thermochromic response make them attractive candidates for a wide range of visual sensing applications. In particular, it is shown that the crystals are excellent candidates for visual strain sensors or integrated time-temperature indicators which act over large temperature windows. Given the versatility of these crystals, this method repre- sents a simple, inexpensive, and scalable approach to produce multifunctional graphene infused synthetic ...
http://hdl.handle.net/2262/94578
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Optimizing fluorescent protein expression for quantitative fluorescence microscopy and spectroscopy using herpes simplex thymidine kinase promoter sequences
(2021)
Ali, Rizwan; Ramadurai, Sivaramakrishnan; Barry, Frank; Nasheuer, Heinz-Peter
Optimizing fluorescent protein expression for quantitative fluorescence microscopy and spectroscopy using herpes simplex thymidine kinase promoter sequences
(2021)
Ali, Rizwan; Ramadurai, Sivaramakrishnan; Barry, Frank; Nasheuer, Heinz-Peter
Abstract:
The modulation of expression levels of fluorescent fusion proteins (FFPs) is central for recombinant DNA technologies in modern biology as overexpression of proteins contributes to artifacts in biological experiments. In addition, some microscopy techniques such as fluorescence correlation spectroscopy (FCS) and single-molecule-based techniques are very sensitive to high expression levels of FFPs. To reduce the levels of recombinant protein expression in comparison with the commonly used, very strong CMV promoter, the herpes simplex virus thymidine kinase (TK) gene promoter, and mutants thereof were analyzed. Deletion mutants of the TK promoter were constructed and introduced into the Gateway (R) system for ectopic expression of enhanced green fluorescent protein (eGFP), monomeric cherry (mCherry), and FFPs containing these FPs. Two promoter constructs, TK2ST and TKTSC, were established, which have optimal low expression levels suitable for FCS studies in U2OS, HeLa CCL2, NIH 3T3, a...
http://hdl.handle.net/10379/16420
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Remote sensing of surface waters in Ireland
(2021)
Agarwal, Anuj; Taveneau, Adélaïde; Olbert, Agnieszka Indiana
Remote sensing of surface waters in Ireland
(2021)
Agarwal, Anuj; Taveneau, Adélaïde; Olbert, Agnieszka Indiana
Abstract:
An implementation of the WFD requires all surface waters in the EU to achieve at least good status; this requirement has not been achieved in Ireland. Just over 30% of transitional waters and 79% of coastal waters were satisfactory at good or high status. Irish transitional and coastal (TraC) waters are threatened by the synergistic effects of multiple environmental pressures such as nutrient enrichment, oxygen depletion and acidification. The overarching aim of this research is to assess a potential use of chlorophyll-a Remotely Sensed (RS) products to inform and improve Irish TraC water monitoring programme under WFD. In this research, the accuracy of level-3 and -4 processed chlorophyll-a concentrations derived from satellite observations of water colour has been analysed for Irish TraC waters. In total four datasets derived from four missions and for four retrieval algorithms have been inter-compared and validated against in-situ data on various temporal and spatial scales. The ...
http://hdl.handle.net/10379/16430
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Evolution of hierarchically-layered Cu-rich silicide nano-architectures
(2020)
Amiinu, Ibrahim Saana; Kapuria, Nilotpal; Adegoke, Temilade Esther; Holzinger, Angelika...
Evolution of hierarchically-layered Cu-rich silicide nano-architectures
(2020)
Amiinu, Ibrahim Saana; Kapuria, Nilotpal; Adegoke, Temilade Esther; Holzinger, Angelika; Geaney, Hugh; Scanlon, Micheál D.; Ryan, Kevin M.
Abstract:
The full text of this article will not be available in ULIR until the embargo expires on the 14/09/2021
A solution based synthesis of well-ordered Cu-rich silicide nano-architectures, consisting of a pair of layered cups and stems (ρ-Cu15Si4 ) is demonstrated. The as-grown ρ-Cu15Si4 typically exhibits distinct interconnected 1D stems, consisting of a stack of nanorods (∼300 nm in length), terminated with concave hexagonal 3D cups that evolve through a self-regulated layer-bylayer growth mechanism. Discrete-time ex situ experimental observations reveal that the ρ-Cu15Si4 evolution is driven by interatomic diffusion, initially triggering the formation of binary-phase silicide islands (spheres) followed by the formation of hexagonal discs, stem growth, and lateral elongation in exactly opposite directions. It is further shown that electrochemically pre-grown Cu-crystals can facilitate direct growth of the ρ-Cu15Si4 in high yield with enhanced substrate coverage.
http://hdl.handle.net/10344/9584
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