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Displaying Results 11401 - 11425 of 11522 on page 457 of 461

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Comparative Genomics Analysis of Lactobacillus ruminis from Different Niches (2021)

Wang, Shuo; Yang, Bo; Ross, R. Paul; STANTON, CATHERINE; Zhao, Jianxin; Zhang, Hao; Che...

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Improving robustness and accuracy of predicted daily methane emissions of dairy cows using milk mid‐infrared spectra (2021)

Vanlierde, Amélie; Dehareng, Frédéric; Gengler, Nicolas; Froidmont, Eric; McParland, Si...

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A review study of water quality index models and their use for assessing surface water quality (2021)

Uddin, Md Galal; Nash, Stephen; Olbert, Agnieszka Indiana

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Assessment of water quality using Water Quality Index (WQI) models and advanced geostatistical technique (2021)

Uddin, Md Galal; Olbert, Agnieszka Indiana; Nash, Stephen

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Application of water quality index models to an Irish estuary (2021)

Uddin, Md Galal; Nash, Stephen; Olbert, Agnieszka Indiana

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Mobilising collective action and constructing positive political identities through ambivalent discourses within the immigration debate (2020)

Nightingale, Alastair

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Multi-Level state interventions and gender equality in higher education institutions: The Irish case (2020)

O'Connor, Pat; Irvine, Gemma

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Building blocks from monosaccharides for synthesis of scaffolds, including macrocycles. Application of allylic azide rearrangement, azide-alkyne cycloaddition and ring closing metathesis (2021)

Fox, Karen A.; Chadda, Rekha; Cardona, Francisco; Barron, Stephen; McArdle, Patrick; Mu...

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Probing sulfatide-tissue lectin recognition with functionalized glycodendrimersomes (2021)

Murphy, Paul V.; Romero, Antonio; Xiao, Qi; Ludwig, Anna-Kristin; Jogula, Srinivas; Shi...

Probing sulfatide-tissue lectin recognition with functionalized glycodendrimersomes (2021)

Murphy, Paul V.; Romero, Antonio; Xiao, Qi; Ludwig, Anna-Kristin; Jogula, Srinivas; Shilova, Nadezhda V.; Singh, Tanuja; Gabba, Adele; Javed, Bilal; Zhang, Dapeng; Medrano, Francisco J.; Kaltner, Herbert; Kopitz, Jürgen; Bovin, Nicolai V.; Wu, Albert M.; Klein, Michael L.; Percec, Virgil; Gabius, Hans-Joachim

Abstract:

The small 3-O-sulfated galactose head group of sulfatides, an abundant glycosphingolipid class, poses the (sphinx-like) riddle on involvement of glycan bridging by tissue lectins (sugar code). First, synthesis of head group derivatives for functionalization of amphiphilic dendrimers is performed. Aggregation of resulting (biomimetic) vesicles, alone or in combination with lactose, demonstrates bridging by a tissue lectin (galectin-4). Physiologically, this can stabilize glycolipid-rich microdomains (rafts) and associate sulfatide-rich regions with specific glycoproteins. Further testing documents importance of heterobivalency and linker length. Structurally, sulfatide recognition by galectin-8 is shown to involve sphingosine's OH group as substitute for the 3′-hydroxyl of glucose of lactose. These discoveries underscore functionality of this small determinant on biomembranes intracellularly and on the cell surface. Moreover, they provide a role model to examine counterreceptor ...