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Governance reform of German food safety regulation: Cosmetic or real? (2006)

Steiner, Bodo E.

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Regulation and firm perception, eco-innovation and firm performance (2012)

Doran, Justin; Ryan, Geraldine

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Economic regulation: recentralisation of power or improved quality of regulation? (2011)

Gorecki, Paul K.

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Competition and Regulation in the Retail Pharmacy Market (2004)

Purcell, Declan

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An economic analysis of the Public Transport Regulation Act, 2009 (2011)

Barrett, Sean D.

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The 'Dance' of Kinship Care in England and Ireland: Navigating a course between regulation and relationships (2013)

GILLIGAN, ROBERT

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Power in The Wind (2018)

O'CONNOR, MICHAEL MARTIN

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NF-κB regulation: The nuclear response (2009)

GRAY, STEVEN; LAWLESS, MATTHEW; KELLEHER, DERMOT; MANKAN, ARUN KUMAR; MCMANUS, ROSS

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The Regulation of Armed Non-State Actors: Promoting the Application of the Laws of War to Conflicts Involving National Liberation Movements (2009)

Higgins, Noelle

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Information and communication technology for environmental regulation: developing a research agenda (2013)

Khoo, Su-Ming; Hickey, Kieran R.

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The aliphatic amidase AmiE is involved in regulation of Pseudomonas aeruginosa virulence (2017)

Clamens, Thomas; Rosay, Thibaut; Crépin, Alexandre; Grandjean, Teddy; Kentache, Takfari...

The aliphatic amidase AmiE is involved in regulation of Pseudomonas aeruginosa virulence (2017)

Clamens, Thomas; Rosay, Thibaut; Crépin, Alexandre; Grandjean, Teddy; Kentache, Takfarinas; Hardouin, Julie; Bortolotti, Perrine; Neidig, Anke; Mooij, Marlies J.; Hillion, Mélanie; Vieillard, Julien; Cosette, Pascal; Overhage, Joerg; O'Gara, Fergal; Bouffartigues, Emeline; Dufour, Alain; Chevalier, Sylvie; Guery, Benoit; Cornelis, Pierre; Feuilloley, Marc G. J.

Abstract:

We have previously shown that the eukaryotic C-type natriuretic peptide hormone (CNP) regulates Pseudomonas aeruginosa virulence and biofilm formation after binding on the AmiC sensor, triggering the amiE transcription. Herein, the involvement of the aliphatic amidase AmiE in P. aeruginosa virulence regulation has been investigated. The proteome analysis of an AmiE over-producing strain (AmiE+) revealed an expression change for 138 proteins, including some that are involved in motility, synthesis of quorum sensing compounds and virulence regulation. We observed that the AmiE+ strain produced less biofilm compared to the wild type, and over-produced rhamnolipids. In the same line, AmiE is involved in P. aeruginosa motilities (swarming and twitching) and production of the quorum sensing molecules N-acyl homoserine lactones and Pseudomonas Quinolone Signal (PQS). We observed that AmiE overproduction reduced levels of HCN and pyocyanin causing a decreased virulence in different hosts (i...