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'regulation' in all fields;
3926 items found
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Displaying Results 101 - 125 of 3926 on page 5 of 158
Marked
Mark
Quantification and regulation of pellet morphology in streptomyces hygroscopicus var; geldanus cultures
(2005)
Ó Cléirigh, Cormac
Quantification and regulation of pellet morphology in streptomyces hygroscopicus var; geldanus cultures
(2005)
Ó Cléirigh, Cormac
Abstract:
Streptomyces hygroscopicus var. geldanus, an actinomycete, produces a range of antibiotic compounds, one of which, Geldanamycin, is currently under investigation for its potential anticancer properties. Filamentous microbes, both bacterial and fungal, possess the ability to grow in a range of morphological forms in submerged fermentations. Secondary metabolite production by filamentous microorganisms is often dependent on the morphology of biomass aggregates within the culture and therefore morphological regulation in such fermentations is desirable in order to produce specific compounds of interest. Morphological assessment of pellet formation and growth necessitated the development of an image analysis technique to allow high throughput morphological characterisation of microbial fermentation broths. An assessment of environmental and nutritional conditions for culturing S. hygroscopicus , concentrating specifically on the impact of nutrient broth composition, spore loading densi...
http://doras.dcu.ie/18112/
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Genetic regulation of iron responsive genes in sinorhizobium meliloti
(2005)
Viguier, Caroline
Genetic regulation of iron responsive genes in sinorhizobium meliloti
(2005)
Viguier, Caroline
Abstract:
Iron is an essential nutrient for most bacteria. It is a crucial metal of many metalloenzymes and functions m important biological systems mamly as the cofactor of redox enzymes Bacteria must acquire iron from the environment where the metal is mainly found in the fem e iron state, which is very insoluble. In addition, they must maintain iron homeostasis. One mechanism used by bacteria for the acquisition of iron is the production of siderophores, which are low molecular weight chelators with affinity and specificity for ferroc iron and which are formed and secreted under iron deplete conditions. The regulation of iron was studied in Sinorhizobium mehloti, which is a free-living Gram-negative bacteria found in soil and also as an endosymbiont o f Medicago sativa (alfalfa). A homologue of the ferric uptake protein (Fur), which regulates the uptake of iron in most Gram-negative bacteria, was identified and characterised However, the results suggest that in S mehloti, Fur does not fun...
http://doras.dcu.ie/18258/
Marked
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Hemodynamic regulation of MMP-2 and MMP-9: roles in angiogenesis and migration
(2004)
Von Offenberg Sweeney, Nicholas
Hemodynamic regulation of MMP-2 and MMP-9: roles in angiogenesis and migration
(2004)
Von Offenberg Sweeney, Nicholas
Abstract:
Hemodynamic forces generated by the flow of blood are crucial in maintaining homeostasis within the blood vessel wall. These forces, namely cyclic strain and shear stress are intricately involved in vascular remodeling, a process which underlies the pathogenesis of cardiovascular diseases such as atherosclerosis and restenosis. Since degradation of the extracellular matrix scaffold enables reshaping of tissue, the role matrix metalloproteinases (MMPs) has become the object of intense recent interest in relation to physiological and pathological vascular remodeling. The culminating data indicates that hemodynamic forces are important regulators of MMP expression and activity. A more complete understanding of the hemodynamic regulation of MMPs may advance the understanding of pathological vascular remodeling. We have investigated the effect of cyclic strain on the endothelial cell migration and angiogenic activity and the role of gelatinases in mediating these responses We have shown...
http://doras.dcu.ie/18261/
Marked
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Effect of surgery and endotoxin on metastatic tumor growth and regulation of VEGF expression and angiogenesis by endotoxin
(2001)
Pidgeon, Graham
Effect of surgery and endotoxin on metastatic tumor growth and regulation of VEGF expression and angiogenesis by endotoxin
(2001)
Pidgeon, Graham
Abstract:
The surgical removal of primary tumours has been associated with the subsequent growth of previously dormant metastases. This accelerated growth has previously been ascribed to the removal of the primary tumour and the anti-angiogenic factors they produce, such as angiostatin and endostatin. Endotoxin or lipopolysaccharide (LPS) is a cell wall constituent of gram negative bacteria, ubiquitously present in air and endogenous gut bacteria, that may be introduced during surgery. LPS has been shown to be angiogenic and vascular endothelial growth factor (VEGF) is the most potent angiogenic cytokine identified to date. The role of endotoxin in surgically induced metastatic tumour growth, the therapeutic use of anti-endotoxin agents in the perioperative period, the regulation of VEGF expression by endotoxin and the effect of VEGF and endotoxin on tumour cell survival was examined. A murine model of experimental metastasis was established where no primary tumour was present. This allowed ...
http://doras.dcu.ie/19273/
Marked
Mark
Investigation of lantibiotic regulation, immunity and synergy
(2014)
Draper, Lorraine A.
Investigation of lantibiotic regulation, immunity and synergy
(2014)
Draper, Lorraine A.
Abstract:
Due to the increasing incidence of antibiotic resistant strains, the use of novel antimicrobials, such as bacteriocins, has become an ever more likely prospect. Lacticin 3147 (of which there are two components, Ltnα and Ltnβ) and nisin belong to the subgroup of bacteriocins called the lantibiotics, which has attracted much attention in recent years. The lantibiotics are antimicrobial peptides that contain unusual amino acids resulting from a series of enzyme-mediated post translational modifications. Given that there have been relatively few examples of lantibiotic-specific resistance; these antimicrobials appear to represent valid alternatives to classical antibiotics. However, the fact that lantibiotics are naturally only produced in small amounts often hinders their commercialisation. In order to overcome this bottleneck, several approaches can be employed. For example, we can create a situation that reduces the quantity of a lantibiotic required to inhibit a target by combining ...
http://hdl.handle.net/10468/1543
Marked
Mark
The regulation of Krox-20 expression reveals important steps in the control of peripheral glial cell development.
(1996)
MURPHY, PAULA
The regulation of Krox-20 expression reveals important steps in the control of peripheral glial cell development.
(1996)
MURPHY, PAULA
Abstract:
peer-reviewed
The zinc finger transcription factor gene Krox-20 is expressed in Schwann cells and is required for the myelination of peripheral nerves. We show that the regulation of Krox-20 expression in peripheral glial cells reveals three important steps in the development and differentiation of these cells. (i) Expression of Krox-20 in Schwann cells requires continuous neuronal signalling via direct axonal contact. Therefore Krox-20 appears to be a key component of the transduction cascade linking axonal signalling to myelination. (ii) Krox-20 inducibility is acquired by Schwann cells at the time that they are formed from their precursors. Diffusible factor(s) synthesised by the neural tube can mediate this transition and can be mimicked by NDFb or a combination of CNTF and bFGF. Furthermore, the neural tube activity is blocked by a hybrid protein containing the NDF-binding domain of the ErbB4 receptor, strongly implicating NDF in the physiological transition. (iii) In senso...
http://hdl.handle.net/2262/24019
Marked
Mark
Epigenetics Underpinning the Regulation of the CXC (ELR+) Chemokines in Non-Small Cell Lung Cancer
(2011)
O'BYRNE, KEN; BAIRD, ANNE-MARIE; GRAY, STEVEN
Epigenetics Underpinning the Regulation of the CXC (ELR+) Chemokines in Non-Small Cell Lung Cancer
(2011)
O'BYRNE, KEN; BAIRD, ANNE-MARIE; GRAY, STEVEN
Abstract:
Background: Angiogenesis may play a role in the pathogenesis of Non-Small Cell Lung cancer (NSCLC). The CXC (ELR+) chemokine family are powerful promoters of the angiogenic response. Methods: The expression of the CXC (ELR+) family members (CXCL1-3/GRO?-?, CXCL8/IL-8, CXCR1/2) was examined in a series of resected fresh frozen NSCLC tumours. Additionally, the expression and epigenetic regulation of these chemokines was examined in normal bronchial epithelial and NSCLC cell lines. Results: Overall, expression of the chemokine ligands (CXCL1, 2, 8) and their receptors (CXCR1/2) were down regulated in tumour samples compared with normal, with the exception of CXCL3. CXCL8 and CXCR1/2 were found to be epigenetically regulated by histone post-translational modifications. Recombinant CXCL8 did not stimulate cell growth in either a normal bronchial epithelial or a squamous carcinoma cell line (SKMES-1). However, an increase was observed at 72 hours post treatment in an adenocarcinoma cell...
http://hdl.handle.net/2262/50748
Marked
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A Mechano-Regulation Model of Fracture Repair in Vertebral Bodies
(2010)
KELLY, DANIEL
A Mechano-Regulation Model of Fracture Repair in Vertebral Bodies
(2010)
KELLY, DANIEL
Abstract:
In this study a multi-scale mechano-regulation model was developed in order to investigate the mechanobiology of trabecular fracture healing in vertebral bodies. A macro-scale finite element model of the spinal segment L3-L4-L5, including a mild wedge fracture in the body of the L4 vertebra, was used to determine the boundary conditions acting on a micro-scale finite element model simulating a portion of fractured trabecular bone. The micro-scale model, in turn, was utilized to predict the local patterns of tissue differentiation within the fracture gap and then how the equivalent mechanical properties of the macro-scale model change with time. The patterns of tissue differentiation predicted by the model appeared consistent with those observed in vivo. Bone formation occurred primarily through endochondral ossification. New woven bone was predicted to occupy the majority of the space within the fracture site approximately 7-8 weeks after the fracture event. Remodeling of cancellous...
http://hdl.handle.net/2262/41080
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Mechano-regulation of stem cell differentiation and tissue regeneration in osteochondral defects
(2005)
KELLY, DANIEL; PRENDERGAST, PATRICK JOHN
Mechano-regulation of stem cell differentiation and tissue regeneration in osteochondral defects
(2005)
KELLY, DANIEL; PRENDERGAST, PATRICK JOHN
Abstract:
peer-reviewed
Cartilage defects that penetrate the subchondral bone can undergo spontaneous repair through the formation of a fibrous or cartilaginous tissue mediated primarily by mesenchymal stem cells from the bone marrow. This tissue is biomechanically inferior to normal articular cartilage, and is often observed to degrade over time. The factors that control the type and quality of the repair tissue, and its subsequent degradation, have yet to be elucidated. In this paper, we hypothesise a relationship between the mechanical environment of mesenchymal stem cells and their subsequent dispersal, proliferation, differentiation and death. The mechano-regulation stimulus is hypothesised to be a function of strain and fluid flow; these quantities are calculated using a finite element model of the tissue. A finite element model of an osteochondral defect in the knee was created, and used to simulate the spontaneous repair process. The model predicts bone formation through both endo...
http://hdl.handle.net/2262/29006
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The tenement homes of Dublin: their condition and regulation
(1899)
Eason, Charles
The tenement homes of Dublin: their condition and regulation
(1899)
Eason, Charles
Abstract:
The condition of the tenement houses of Dublin was enquired into by the Royal Commission upon the Sewerage and Drainage of Dublin in 1879. Their report states that "9,760 houses were occupied as dwellings let in tenements," and that of these 2,300, occupied by about 30,000 persons, were in a condition unfit for habitation. The report recommends the gradual closing of the ruinous houses, and the supervision and daily regulation of the others, and it also says that by the provision of improved sanitary accommodation, and the strict enforcement of the provisions of the Public Health Act against overcrowding, a considerable proportion of the tenement houses can be converted into healthy dwellings. The report pointed out that it is the duty of the Corporation to determine how many persons are to be allowed to occupy each room, and to ascertain, by frequent inspection, that the number fixed upon be not exceeded. The Commissioners affirmed "that the tenement houses of Dublin...
http://hdl.handle.net/2262/7261
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The Alert Programme for Self Regulation - an evaluation of a group based intervention for children attending a child and adolescent mental health clinic
(2011)
CREMIN, KATIE
The Alert Programme for Self Regulation - an evaluation of a group based intervention for children attending a child and adolescent mental health clinic
(2011)
CREMIN, KATIE
http://hdl.handle.net/2262/64032
Marked
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Experimental validation of CFD modelling for thermal regulation o photovoltaic panels using phase change material
(2011)
Sarwar, SARAH; MC CORMACK; Huang; Norton
Experimental validation of CFD modelling for thermal regulation o photovoltaic panels using phase change material
(2011)
Sarwar, SARAH; MC CORMACK; Huang; Norton
http://hdl.handle.net/2262/67169
Marked
Mark
Differential filamentation of Candida albicans and C. dubliniensis is governed by nutrient regulation of UME6 expression
(2010)
SULLIVAN, DEREK; MORAN, GARY
Differential filamentation of Candida albicans and C. dubliniensis is governed by nutrient regulation of UME6 expression
(2010)
SULLIVAN, DEREK; MORAN, GARY
Abstract:
Candida dubliniensis is closely related to C. albicans, however it is responsible for fewer infections in humans and is less virulent in animal models of infection. C. dubliniensis forms fewer hyphae in vivo and this may contribute to its reduced virulence. In this study we show that unlike C. albicans, C. dubliniensis fails to form hyphae in YPD supplemented with 10% (v/v) fetal calf serum (YPDS). However, C. dubliniensis filaments in water plus 10% (v/v) fetal calf serum (WS), and this filamentation is inhibited by the addition of peptone and glucose. Repression of filamentation in YPDS could be partly overcome by preculture in synthetic Lee?s medium. Unlike C. albicans, inoculation of C. dubliniensis in YPDS did not result in increased UME6 transcription. However, >100-fold induction of UME6 was observed when C. dubliniensis was inoculated in nutrient poor WS medium. Addition of increasing concentrations of peptone to WS had a dose dependent effect on reducing UME6 e...
http://hdl.handle.net/2262/41042
Marked
Mark
Counter-regulation in the IKK family.
(2011)
O'NEILL, LUKE
Counter-regulation in the IKK family.
(2011)
O'NEILL, LUKE
Abstract:
The human IKK [I?B (inhibitor of NF-?B) kinase] family has four members; they are the central kinases of innate immunity. Two members, IKK? and IKK?, the so-called canonical members, phosphoryate I?B?, leading to activation of the transcription factor NF-?B (nuclear factor ?B), which controls the expression of many immune and inflammatory genes. The IKK-related proteins TBK-1 (TANK-binding kinase 1) and IKK? have a different substrate--IRF3 (interferon regulatory factor 3)--which regulates a different set of genes, the products of which include Type I interferons. Toll-like receptors (TLRs) such as the lipopolysaccharide receptor TLR4 or the poly(I:C) receptor TLR3 activate each of the IKKs, but the pro-inflammatory cytokine IL-1 (interleukin 1), which signals in a broadly similar way to the TLRs, has so far been shown to activate only the canonical IKKs. In this issue of the Biochemical Journal, Clark et al. bring new insights into the regulation of IKKs. They demonstrate that IL-1...
http://hdl.handle.net/2262/57380
Marked
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Role of KLF4 in regulation of myocardin induced SMC differentiation in human smooth muscle stem progenitor cells (hSMSPC)
(2013)
Govindarajan, Kalaimathi
Role of KLF4 in regulation of myocardin induced SMC differentiation in human smooth muscle stem progenitor cells (hSMSPC)
(2013)
Govindarajan, Kalaimathi
Abstract:
The differentiation of stem cells into multiple lineages has been explored in vascular regenerative medicine. However, in the case of smooth muscle cells (SMC), issues exist concerning inefficient rates of differentiation. In stem cells, multiple repressors potentially downregulate myocardin, the potent SRF coactivator induced SMC transcription including Krüppel like zinc finger transcription factor-4 (KLF4). This thesis aimed to explore the role of KLF4 in the regulation of myocardin gene expression in human smooth muscle stem/progenitor cells (hSMSPC), a novel circulating stem cell identified in our laboratory which expresses low levels of myocardin and higher levels of KLF4. hSMSPC cells cultured in SmGM2 1% FBS with TGF-β1 (5 ng/ml “differentiation media”) show limited SMC cell differentiation potential. Furthermore, myocardin transduced hSMSPC cells cultured in differentiation media induced myofilamentous SMC like cells with expression of SM markers. Five potential KLF4 binding...
http://hdl.handle.net/10468/1670
Marked
Mark
Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival
(2013)
MURRAY, JAMES
Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival
(2013)
MURRAY, JAMES
Abstract:
Hypoxia in the microenvironment of many solid tumours is an important determinant of malignant progression. The ISR (integrated stress response) protects cells from the ER (endoplasmic reticulum) stress caused by severe hypoxia. Likewise, autophagy is a mechanism by which cancer cells can evade hypoxic cell death. In the present paper we report that the autophagy-initiating kinase ULK1 (UNC51-like kinase 1) is a direct transcriptional target of ATF4 (activating transcription factor 4), which drives the expression of ULK1 mRNA and protein in severe hypoxia and ER stress. We demonstrate that ULK1 is required for autophagy in severe hypoxia and that ablation of ULK1 causes caspase-3/7-independent cell death. Furthermore, we report that ULK1 expression is associated with a poor prognosis in breast cancer. Collectively, the findings of the present study identify transcriptional up-regulation of ULK1 as a novel arm of the ISR, and suggest ULK1 as a potentially effective target for cancer ...
http://hdl.handle.net/2262/72159
Marked
Mark
Regulation of IL-1?-induced NF-?B by hydroxylases links key hypoxic and inflammatory signaling pathways.
(2013)
FALLON, PADRAIC; HAMS, EMILY
Regulation of IL-1?-induced NF-?B by hydroxylases links key hypoxic and inflammatory signaling pathways.
(2013)
FALLON, PADRAIC; HAMS, EMILY
Abstract:
Hypoxia is a prominent feature of chronically inflamed tissues. Oxygen-sensing hydroxylases control transcriptional adaptation to hypoxia through the regulation of hypoxia-inducible factor (HIF) and nuclear factor ?B (NF-?B), both of which can regulate the inflammatory response. Furthermore, pharmacologic hydroxylase inhibitors reduce inflammation in multiple animal models. However, the underlying mechanism(s) linking hydroxylase activity to inflammatory signaling remains unclear. IL-1?, a major proinflammatory cytokine that regulates NF-?B, is associated with multiple inflammatory pathologies. We demonstrate that a combination of prolyl hydroxylase 1 and factor inhibiting HIF hydroxylase isoforms regulates IL-1?-induced NF-?B at the level of (or downstream of) the tumor necrosis factor receptor-associated factor 6 complex. Multiple proteins of the distal IL-1?-signaling pathway are subject to hydroxylation and form complexes with either prolyl hydroxylase 1 or factor inhibiting HIF...
http://hdl.handle.net/2262/72443
Marked
Mark
Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.
(2013)
FALLON, PADRAIC
Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.
(2013)
FALLON, PADRAIC
Abstract:
Hypoxia is a prominent feature of chronically inflamed tissues. Oxygen-sensing hydroxylases control transcriptional adaptation to hypoxia through the regulation of hypoxia-inducible factor (HIF) and nuclear factor ?B (NF-?B), both of which can regulate the inflammatory response. Furthermore, pharmacologic hydroxylase inhibitors reduce inflammation in multiple animal models. However, the underlying mechanism(s) linking hydroxylase activity to inflammatory signaling remains unclear. IL-1?, a major proinflammatory cytokine that regulates NF-?B, is associated with multiple inflammatory pathologies. We demonstrate that a combination of prolyl hydroxylase 1 and factor inhibiting HIF hydroxylase isoforms regulates IL-1?-induced NF-?B at the level of (or downstream of) the tumor necrosis factor receptor-associated factor 6 complex. Multiple proteins of the distal IL-1?-signaling pathway are subject to hydroxylation and form complexes with either prolyl hydroxylase 1 or factor inhibiting HIF...
http://hdl.handle.net/2262/73002
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Co-operative roles for DNA supercoiling and nucleoid-associated proteins in the regulation of bacterial transcription
(2013)
DORMAN, CHARLES
Co-operative roles for DNA supercoiling and nucleoid-associated proteins in the regulation of bacterial transcription
(2013)
DORMAN, CHARLES
Abstract:
DNA supercoiling and NAPs (nucleoid-associated proteins) contribute to the regulation of transcription of many bacterial genes. The horizontally acquired SPI (Salmonella pathogenicity island) genes respond positively to DNA relaxation, they are activated and repressed by the Fis (factor for inversion stimulation) and H-NS (histone-like nucleoid-structuring) NAPs respectively, and are positively controlled by the OmpR global regulatory protein. The ompR gene is autoregulated and responds positively to DNA relaxation. Binding of the Fis and OmpR proteins to their targets in DNA is differentially sensitive to its topological state, whereas H-NS binds regardless of the topological state of the DNA. These data illustrate the overlapping and complex nature of NAP and DNA topological contributions to transcription control in bacteria.
http://hdl.handle.net/2262/73031
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Mark
Charge profile analysis reveals that activation of pro-apoptotic regulators Bax and Bak relies on charge transfer mediated allosteric regulation.
(2012)
Ionescu, Crina-Maria; Svobodová Vařeková, Radka; Prehn, Jochen HM; Huber, Heinrich J; K...
Charge profile analysis reveals that activation of pro-apoptotic regulators Bax and Bak relies on charge transfer mediated allosteric regulation.
(2012)
Ionescu, Crina-Maria; Svobodová Vařeková, Radka; Prehn, Jochen HM; Huber, Heinrich J; Koča, Jaroslav
Abstract:
<p>This article is also available at <a href="http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1002565">http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1002565</a></p>
<p>The pro-apoptotic proteins Bax and Bak are essential for executing programmed cell death (apoptosis), yet the mechanism of their activation is not properly understood at the structural level. For the first time in cell death research, we calculated intra-protein charge transfer in order to study the structural alterations and their functional consequences during Bax activation. Using an electronegativity equalization model, we investigated the changes in the Bax charge profile upon activation by a functional peptide of its natural activator protein, Bim. We found that charge reorganizations upon activator binding mediate the exposure of the functional sites of Bax, rendering Bax active. The affinity of the Bax C-domain for it...
https://epubs.rcsi.ie/physiolart/32
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Mark
Investigation into the role of La/SS-B in Interferon regulation and its relevance in health and human disease
(2014)
Mahony, Rebecca G
Investigation into the role of La/SS-B in Interferon regulation and its relevance in health and human disease
(2014)
Mahony, Rebecca G
Abstract:
<p>The La/SS-B protein is well documented as an autoantigen for autoimmune conditions such as systemic lupus erythematosus (SLE). Recently, a link between La and viruses has been reported, an interesting observation given the fact that viral infection is a significant risk factor in SLE. However, the direct mechanism by which La functions in the innate immune response to viral challenge remains elusive. As such, we sought to investigate whether La directly regulates the induction of the anti-viral cytokines, type I Interferons, (IFNs) by direct modulation of innate immune toll-like receptor (TLR) or RIG-I-like receptor (RLR) signalling pathways.</p> <p>Our findings have highlighted a dual and complex role for La in the regulation of IFN production. Initial studies demonstrated a role for La in the specific attenuation of IFN promoter transcriptional activity downstream of RLR activation. In confirmation of this, elevated IFN levels were observed following La knockd...
https://epubs.rcsi.ie/phdtheses/119
Marked
Mark
Regulating Everything: From Mega- to Meta-regulation
(2015)
Scott, Colin
Regulating Everything: From Mega- to Meta-regulation
(2015)
Scott, Colin
Abstract:
Such is the extent of contemporary regulatory governance that it is possible to characterise the ambition of governments as ‘regulating everything’. This article contrasts the highly visible growth in numbers and scope of regulatory agencies in Ireland, with the more hidden but highly significant diffusion of regulatory capacity which is evident within regulatory regimes. I argue that the concept of the ‘regulatory regime’ is helpful for resisting the tendency to overstate the power and significance of regulatory agencies and to draw in other kinds of actors and other forms of control into our view of governance. I argue that the fragmentation in terms of organisations and forms of control within regulatory regimes creates a problem involving regulatory agencies not of too much power and too little accountability, but rather the converse – too little power and too much accountability. The reconceptualization of regulation which I offer in this article is centrally concerned with que...
http://hdl.handle.net/10197/7011
Marked
Mark
Licensing as a Tool of Regulation and Governance
(2015)
Scott, Colin
Licensing as a Tool of Regulation and Governance
(2015)
Scott, Colin
Abstract:
Licensing originates from more general practices of those with property rights carving out part of their interest to give limited rights to others in respect of their property, for example having rights to visit or stay on land, or to use copyrighted mater ial by performing a play or a song. In the armoury of tools and techniques for regulation licensing has a central place as the exercise of state control seeking to secure particular social and economic outcomes. The state’s capacity to license is special, as it is linked to the state monopoly over legitimate coercive power
http://hdl.handle.net/10197/7018
Marked
Mark
An investigation into why companies delist from the main market on the Irish stock market to the Irish enterprise exchange and the impact of regulation
(2009)
Harkin, Sarah
An investigation into why companies delist from the main market on the Irish stock market to the Irish enterprise exchange and the impact of regulation
(2009)
Harkin, Sarah
Abstract:
The Irish Stock Exchange (ISE) established a new market in 2005, the Irish Enterprise Exchange (IEX). The main difference between these markets is that less regulations are required under the IEX. One of the objectives of the IEX market was to act as a “stepping stone” where companies would eventually list on the Main Market (MM). Instead it has seen companies delisting from the MM and re-listing on the IEX. Thus, in this study the researcher examined the reasons for this and if regulation had an impact on this. In conducing the study the researcher used both primary and secondary research. The researcher used semi-structured interviews with a sample of companies that had delisted and two regulatory bodies, the Office Director of Corporate Enforcement (ODCE) and the ISE. This allowed the researcher to attempt to examine why companies delisted between the two markets. The findings suggest that the size of a company was a key reason to delist from the MM to the IEX and the cost of bee...
http://hdl.handle.net/10759/322818
Marked
Mark
Financial Industry Ontologies for Risk and Regulation Data (FIORD): a position paper
(2014)
Koumpis, Adamantios
Financial Industry Ontologies for Risk and Regulation Data (FIORD): a position paper
(2014)
Koumpis, Adamantios
Abstract:
Conference paper
This paper presents a proposed approach to address risk andregulation management within the highly active and volatile financial domainby employing semantic based technologies within a collaborative networksenvironment. Firstly the problems and motivation are introduced, with accenton big data and high frequency trading issues that are creating major problemsto the current software systems. Secondly the state of the art on Big Data,Regulation and Risk Management are presented. Next the FIORD platformarchitecture is detailed and the envisioned approach explained. Finallyconclusions are presented where benefits for real time monitoring areemphasized so high frequency trading irregularities are detected in real time forthe benefit of involved financial institutions.
http://hdl.handle.net/10379/4104
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