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Displaying Results 151 - 175 of 3816 on page 7 of 153

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Investigation of the regulation of Bcl-2 family members in apoptosis and cancer (2010)

Sheridan, Clare

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Collective organisation and external regulation of professional rugby league in the United Kingdom (2010)

O'Leary, Leanne

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Under a new light: Regulation of light-dependent pathways by non-coding RNAs (2018)

Sánchez-Retuerta, Camila; Suaréz-López, Paula; Henriques, Rossana

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Performance enhancement of wind turbine power regulation by switched linear control (1996)

Leith, Douglas J.; Leithead, W.E.

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Optimal metabolic regulation by temporal variation of enzyme activities: a control theoretic approach (2007)

Oyarzun, Diego; Ingalls, Brian; Kalamatianos, Dimitrios

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Sliding Doors Cost Measurement: The Net Economic Cost of Lax Regulation of the Irish Banking Sector (2012)

Connor, Gregory; O'Kelly, Brian

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Regulation of Surfactant Protein B Gene Expression in Bone Marrow-Derived Cells (2009)

Field-Corbett, Ciara; English, Karen; O'Dea, Shirley

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Substrate-Promoted Formation of a Catalytically Competent Binuclear Center and Regulation of Reactivity in a Glycerophosphodiesterase from Enterobacter aerogenes (2008)

Hadler, Kieran S.; Tanifum, Eric A.; Hsu-Chen Yip, Sylvia; Mitic, Natasa; Guddat, Luke ...

Substrate-Promoted Formation of a Catalytically Competent Binuclear Center and Regulation of Reactivity in a Glycerophosphodiesterase from Enterobacter aerogenes (2008)

Hadler, Kieran S.; Tanifum, Eric A.; Hsu-Chen Yip, Sylvia; Mitic, Natasa; Guddat, Luke W.; Jackson, Colin J.; Gahan, Lawrence R.; Nguyen, Kelly; Carr, Paul D.; Ollis, David L.; Hengge, Alvan C.; Larrabee, James A.; Schenk, Gerhard

Abstract:

The glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes is a promiscuous binuclear metallohydrolase that catalyzes the hydrolysis of mono-, di-, and triester substrates, including some organophosphate pesticides and products of the degradation of nerve agents. GpdQ has attracted recent attention as a promising enzymatic bioremediator. Here, we have investigated the catalytic mechanism of this versatile enzyme using a range of techniques. An improved crystal structure (1.9 Å resolution) illustrates the presence of (i) an extended hydrogen bond network in the active site, and (ii) two possible nucleophiles, i.e., water/hydroxide ligands, coordinated to one or both metal ions. While it is at present not possible to unambiguously distinguish between these two possibilities, a reaction mechanism is proposed whereby the terminally bound H2O/OH- acts as the nucleophile, activated via hydrogen bonding by the bridging water molecule. Furthermore, the presence of substrate promotes th...

http://mural.maynoothuniversity.ie/3701/

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The chemokine receptor CCR9 is required for the T cellmediated regulation of chronic ileitis in mice (2011)

Wermers, Joshua D.; McNamee, Eóin N.; Wurbel, Marc-André; Jedlicka, Paul; Rivera-Nieves...

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Keep Calm and Carry On: Children’s Self-Regulation in Early Years Settings (2015)

McNally, S.; Maguire, Rebecca

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HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity (2015)

Saeedi, Bejan J.; Kao, Daniel J.; Kitzenberg, D.A.; Dobrinskikh, Evgenia; Schwisow, Kay...

HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity (2015)

Saeedi, Bejan J.; Kao, Daniel J.; Kitzenberg, D.A.; Dobrinskikh, Evgenia; Schwisow, Kayla D.; Masterson, Joanne C.; Kendrick, Agnieszka A.; Kelly, Caleb J.; Bayless, A.; Kominsky, Douglas J.; Campbell, Eric L.; Kuhn, Kristine A.; Furuta, Glenn T.; Colgan, S.P.; Glover, Louise

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Intestinal epithelial cells (IECs) are exposed to profound fluctuations in oxygen tension and have evolved adaptive transcriptional responses to a low-oxygen environment. These adaptations are mediated primarily through the hypoxia-inducible factor (HIF) complex. Given the central role of the IEC in barrier function, we sought to determine whether HIF influenced epithelial tight junction (TJ) structure and function. Initial studies revealed that short hairpin RNA–mediated depletion of the HIF1β in T84 cells resulted in profound defects in barrier and nonuniform, undulating TJ morphology. Global HIF1α chromatin immunoprecipitation (ChIP) analysis identified claudin-1 (CLDN1) as a prominent HIF target gene. Analysis of HIF1β-deficient IEC revealed significantly reduced levels of CLDN1. Overexpression of CLDN1 in HIF1β-deficient cells resulted in resolution of morphological abnormalities and restoration of barrier function. ChIP and site-directed mutagenesis revealed prominent hypoxia ...

http://mural.maynoothuniversity.ie/12486/

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Tissue Specific Regulation of Glucocorticoids in Severe Obesity and the Response to Significant Weight Loss Following Bariatric Surgery (BARICORT) (2015)

Woods, Conor; Corrigan, Michelle; Gathercole, L.; Taylor, A.; Hughes, B.; Gaoatswe, Gad...

Tissue Specific Regulation of Glucocorticoids in Severe Obesity and the Response to Significant Weight Loss Following Bariatric Surgery (BARICORT) (2015)

Woods, Conor; Corrigan, Michelle; Gathercole, L.; Taylor, A.; Hughes, B.; Gaoatswe, Gadintshware; Manolopoulos, K.; Hogan, Andrew; O'Connell, Jean; Stewart, P.M.; Tomlinson, J.W.; O'Shea, Donal; Sherlock, M.

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Context: Tissue cortisol exposure is under the control of the isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD). 11β-HSD1 in vivo, acts as an oxoreductase converting inactive cortisone to active cortisol. We hypothesized that 11β-HSD1 activity is dysregulated in obesity and alters following bariatric surgery induced weight loss in different tissues. Methods: We recruited 21 patients prior to undergoing bariatric surgery and performed cortisol generation profiles (following oral cortisone administration), urinary corticosteroid metabolite analysis, adipose tissue microdialysis, and tissue gene expression before and after weight loss, following bariatric surgery. Archived tissue samples from 20 previous bariatric surgery patients were also used for tissue gene expression studies. Results: Gene expression showed a positive correlation with 11β-HSD1 and BMI in omental adipose tissue (OM) (r = +0.52, P = .0001) but not sc adipose tissue (r = +0.28, P = .17). 11β-HSD1 expression i...

http://mural.maynoothuniversity.ie/12419/