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Displaying Results 51 - 75 of 3199 on page 3 of 128

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Evaluation of Phase Change Materials for Thermal Regulation Enhancement of Building Integrated Photovoltaics (2010)

Hasan, A.; McCormack, Sarah; Huang, M.; Norton, Brian

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Female sexuality in Ireland 1920 to 1940: Construction and regulation (1999)

Leane, Máire

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Institutional change and conflict regulation : the Anglo-Irish Agreement (1985) and the mechanisms of change in Northern Ireland (2010)

Todd, Jennifer

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Social regulation, medicalisation and the nurse's role: insights from an analysis of nursing documentation (2013)

Hyde, Abbey; Treacy, Margaret P.; Scott, Anne P.; MacNeela, Padraig; Butler, Michelle; ...

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Investigation of lantibiotic regulation, immunity and synergy (2014)

Draper, Lorraine A.

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The regulation of Krox-20 expression reveals important steps in the control of peripheral glial cell development. (1996)

MURPHY, PAULA

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Epigenetics Underpinning the Regulation of the CXC (ELR+) Chemokines in Non-Small Cell Lung Cancer (2011)

O'BYRNE, KEN; BAIRD, ANNE-MARIE; GRAY, STEVEN

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A Mechano-Regulation Model of Fracture Repair in Vertebral Bodies (2010)

KELLY, DANIEL

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Mechano-regulation of stem cell differentiation and tissue regeneration in osteochondral defects (2005)

KELLY, DANIEL; PRENDERGAST, PATRICK JOHN

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The tenement homes of Dublin: their condition and regulation (1899)

Eason, Charles

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The Alert Programme for Self Regulation - an evaluation of a group based intervention for children attending a child and adolescent mental health clinic (2011)

CREMIN, KATIE

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Experimental validation of CFD modelling for thermal regulation o photovoltaic panels using phase change material (2011)

Sarwar, SARAH; MC CORMACK; Huang; Norton

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Differential filamentation of Candida albicans and C. dubliniensis is governed by nutrient regulation of UME6 expression (2010)

SULLIVAN, DEREK; MORAN, GARY

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Counter-regulation in the IKK family. (2011)

O'NEILL, LUKE

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Substrate-Promoted Formation of a Catalytically Competent Binuclear Center and Regulation of Reactivity in a Glycerophosphodiesterase from Enterobacter aerogenes (2008)

Hadler, Kieran S.; Tanifum, Eric A.; Hsu-Chen Yip, Sylvia; Mitic, Natasa; Guddat, Luke ...

Substrate-Promoted Formation of a Catalytically Competent Binuclear Center and Regulation of Reactivity in a Glycerophosphodiesterase from Enterobacter aerogenes (2008)

Hadler, Kieran S.; Tanifum, Eric A.; Hsu-Chen Yip, Sylvia; Mitic, Natasa; Guddat, Luke W.; Jackson, Colin J.; Gahan, Lawrence R.; Nguyen, Kelly; Carr, Paul D.; Ollis, David L.; Hengge, Alvan C.; Larrabee, James A.; Schenk, Gerhard

Abstract:

The glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes is a promiscuous binuclear metallohydrolase that catalyzes the hydrolysis of mono-, di-, and triester substrates, including some organophosphate pesticides and products of the degradation of nerve agents. GpdQ has attracted recent attention as a promising enzymatic bioremediator. Here, we have investigated the catalytic mechanism of this versatile enzyme using a range of techniques. An improved crystal structure (1.9 Å resolution) illustrates the presence of (i) an extended hydrogen bond network in the active site, and (ii) two possible nucleophiles, i.e., water/hydroxide ligands, coordinated to one or both metal ions. While it is at present not possible to unambiguously distinguish between these two possibilities, a reaction mechanism is proposed whereby the terminally bound H2O/OH- acts as the nucleophile, activated via hydrogen bonding by the bridging water molecule. Furthermore, the presence of substrate promotes th...