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Current Search:
'regulation' in all fields;
3876 items found
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Displaying Results 51 - 75 of 3876 on page 3 of 156
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A meta-risk regulation approach to financial and corporate governance failure: lessons from Anglo Irish Bank’s Minsky moment
(2014)
O'Sullivan, Kenneth
A meta-risk regulation approach to financial and corporate governance failure: lessons from Anglo Irish Bank’s Minsky moment
(2014)
O'Sullivan, Kenneth
Abstract:
This thesis examines the roots of regulation in modern policymaking, with particular attention given to the evolution of financial regulation and corporate governance in Ireland. Through case study evidence of Anglo Irish Bank’s failure, it shows that when banks are systemic in nature, inadequate internal risk controls within a Minsky credit cycle can lead to destabilising macroeconomic conditions, which may prolong the effects of a credit-induced downturn. The thesis proposes the adoption of a supervisory approach based on meta-risk regulation (MRR), which is designed to strengthen the risk management practices of regulators and banks. It also shows that well governed firms operating in weak country-level governance structures receive an ‘investability’ premium. This may provide an incentive for firms in emerging markets, or ones operating in lax regulatory environments, to buffer their internal risk management practices in line with MRR.
http://hdl.handle.net/10344/4250
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Corruption, Institutions and Regulation
(2015)
Breen, Michael; Gillanders, Robert
Corruption, Institutions and Regulation
(2015)
Breen, Michael; Gillanders, Robert
Abstract:
We analyze the effects of corruption and institutional quality on the quality of business regulation. Our key findings indicate that corruption negatively aspects the quality of regulation and that general institutional quality is insignificant once corruption is controlled for. These findings hold over a number of specifications which include additional exogenous historical and geographic controls. The findings imply that policy-makers should focus on curbing corruption to improve regulation, over wider institutional reform.
http://hdl.handle.net/10197/6381
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Private Regulation of the Public Sector: A Neglected Facet of Contemporary Governance
(2015)
Scott, Colin
Private Regulation of the Public Sector: A Neglected Facet of Contemporary Governance
(2015)
Scott, Colin
Abstract:
The centrality of regulation among the tools deployed by governments is well established in the social science literature. Regulation of public sector bodies by non-state organizations is an important but neglected aspect of contemporary governance arrangements. Some private regulators derive both authority and power from a legal mandate for their activities. Statutory powers are exercised by private regulators where they are delegated or contracted out. Contractual powers take collective (for example, self-regulatory) and individuated forms. But a further important group of private regulators, operating both nationally and internationally, lack a legal mandate and yet have the capacity to exercise considerable power in constraining governments and public agencies. In a number of cases private regulators operate more complete regulatory regimes (in the sense of controlling standard setting, monitoring, and enforcement elements) than is true of public regulators. While private regula...
http://hdl.handle.net/10197/6737
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The Regulation of Stem Cell Research in Ireland
(2013)
Staunton, Ciara
The Regulation of Stem Cell Research in Ireland
(2013)
Staunton, Ciara
Abstract:
This thesis explores the regulation of stem cell research internationally with a view to providing a suitable regulatory framework for Ireland. It examines the ethical, legal and economic issues which can is raised by stem cell research. Due to the uncertain status of embryos in vitro, this study focuses almost exclusively on embryonic stem cell research (ESCR). However, this study offers recommendations that apply equally to all forms of stem cell research. The impact that the ethical discourse on the status of the embryo should have on public policy is also explored. While this thesis does not seek to defend a particular ethical viewpoint on the moral status of the embryo, it does provide recommendations on how public policy may be formulated in light of this debate. It then assesses the differing approaches to regulation, including traditional 'command-and-control' methods such as legislation and independent regulatory authorities, and reliance on economic instruments s...
http://hdl.handle.net/10379/3716
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Balancing regulation and support in child protection: using theories of power to develop reflective tools for practice
(2016)
McGregor, Caroline
Balancing regulation and support in child protection: using theories of power to develop reflective tools for practice
(2016)
McGregor, Caroline
Abstract:
The aim of this paper is to explore the theme of Regulation and Support in Child Protection with a view to considering how selective use of abstract theory (in this instance, related to power) can be used to enhance existing practice guidance and tools for supervision. By way of illustration, I use the example of understanding the balance between support and regulation in Child Protection to show how theories of power can inform practice. The focus is specifically on the skill of mediating between care and control/support and regulation in child protection and welfare. A number of frameworks for reflection in supervision are proposed. The paper concludes with the argument that we need to think of power along a continuum from No power to All power, accepting that it is rarely the case that we find ourselves, our organisations or our service users with totally no power or absolute power.
http://hdl.handle.net/10147/617865
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Overview of the regulation of medical devices and drugs in the European Union and the United States
(2016)
Masterson, Fiona; Corcoran, Kathryn
Overview of the regulation of medical devices and drugs in the European Union and the United States
(2016)
Masterson, Fiona; Corcoran, Kathryn
Abstract:
This article provides an overview of the regulation of medical devices and drugs in the European Union and the US. It is important for all stakeholders involved in bringing a medical device or drugs to market to have an understanding of the regulatory requirements involved in this process. This article demonstrates that the regulation of these products is an extremely complex process.
This work was funded by a Fellowship in the College of Engineering and Informatics, National University of Ireland, Galway, Ireland.
http://hdl.handle.net/10379/6175
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Transcriptional regulation by the ubiquitin system in model plant Arabidopsis thaliana
(2014)
Hanczaryk, Katarzyna
Transcriptional regulation by the ubiquitin system in model plant Arabidopsis thaliana
(2014)
Hanczaryk, Katarzyna
Abstract:
THESIS 10355
In eukaryotes, the ubiquitin (Ub) system controls protein stability and regulates many developmental and physiological processes, in part through the regulation of transcription. Recent data show that some components of the Ub system act as bona fide transcriptional co-activators by removing from the promoter of target genes ?spent? transcription factors that have become inactive after promoting transcription. After degradation of the ?spent? transcription factor, a ?fresh? and active one binds to the promoter of target genes to maintain transcription. More cases of such regulation by components of the Ub system have been emerged recently, including the first one in plants. Indeed, it has been shown that the protein UNUSUAL FLORAL ORGANS (UFO) in the model plant Arabidopsis thaliana acts as a transcriptional co-activator of the transcription factor LEAFY (LEY) in the regulation of flower development. UFO is an F-box protein, which is part of so-called SCF complexes....
http://hdl.handle.net/2262/79012
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Public issues in media: regulation, accountability and the freedom of the press
(2012)
Horgan, John
Public issues in media: regulation, accountability and the freedom of the press
(2012)
Horgan, John
http://doras.dcu.ie/21792/
Marked
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Self-regulation in entrepreneurs: integrating action, cognition, motivation and emotions
(2017)
O'Shea, Deirdre; Buckley, Finian; Halbesleben, Jonathon R. B
Self-regulation in entrepreneurs: integrating action, cognition, motivation and emotions
(2017)
O'Shea, Deirdre; Buckley, Finian; Halbesleben, Jonathon R. B
Abstract:
Psychological processes (e.g. cognition, motivation, emotions) have emerged as key to understanding entrepreneurial actions and success. Currently, we do not know enough about specific entrepreneurial psychological processes and particularly lack knowledge about their cumulative or interactive effects. Self-regulation offers some promise in understanding these issues. However, self-regulation in entrepreneurship has not been fully explored, which limits our understanding. We address this by introducing an integrated model of episodic self-regulation (the A-CEM-A model) to map the reciprocal regulatory effects of action, cognition, emotion, and motivation in entrepreneurship research and isolate a series of propositions stemming from the model. We further explore the resource implications of the A-CEM-A model for entrepreneurs managing several self-regulatory processes simultaneously. The A-CEM-A model offers a novel and unique insight on entrepreneurial action and psychological proc...
http://hdl.handle.net/10344/5880
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Self-Regulation: Learning Across Disciplines
(2019)
Booth, Ailbhe; Hennessy, Eilis; Doyle, Orla
Self-Regulation: Learning Across Disciplines
(2019)
Booth, Ailbhe; Hennessy, Eilis; Doyle, Orla
Abstract:
The capacity to self-regulate is a key developmental ability that has become a focal point for research across multiple disciplines. Yet interdisciplinary collaboration on self-regulation is rare and the term is often applied in different ways across studies. Drawing on literature from psychology, medical sciences, sociology, and economics, this article provides a synthesis of disciplinary approaches to research on self-regulation. A review of search returns from one prominent database per discipline is used to investigate overlap and divergence on the topic. This review argues that interdisciplinary collaboration has the potential to integrate perspectives on self-regulation into a more coherent body of work, resulting in advances that could not be achieved through any one discipline alone. The review also identifies and discusses three current impediments to collaboration: terminology, measurement, and disciplinary conventions.
Irish Research Council
http://hdl.handle.net/10197/9908
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The Democratic Challenges of Effective Private Regulation and Enforcement
(2019)
Scott, Colin
The Democratic Challenges of Effective Private Regulation and Enforcement
(2019)
Scott, Colin
Abstract:
Effective private regulation and enforcement presents a challenge to a view of democratic states and governance that the state, by virtue of electoral politics, should have a monopoly over coercive power. However, there is nothing new in the observation of the importance of private power to regulate others. Private regulation clearly belongs in the catalogue of significant regulatory power and in this chapter I suggest how practices of private regulation and enforcement might be accommodated within democratic theory and practice. I suggest in this chapter that if we take the idea of decentring seriously and recognise the emergence of a decentralised nodal governance over many economic and social activities, then we can see the role of governance nodes away from central government not simply as monitoring or scrutinising, but also as originating and performing in respect of key governance activities. This observation transforms the democratic challenge. Instead of trying to pull dece...
http://hdl.handle.net/10197/10806
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Investigating regulation of gene transcription by the Tup1-Ssn6 co-repressor complex in Saccharomyces cerevisiae
(2015)
Church, Michael
Investigating regulation of gene transcription by the Tup1-Ssn6 co-repressor complex in Saccharomyces cerevisiae
(2015)
Church, Michael
Abstract:
THESIS 11034
Transcriptional repression is an important part of gene regulation. In the budding yeast Saccharomyces cerevisiae the Tup1-Ssn6 corepressof complex is recruited to gene promoters to repress transcription in response to nutrient depiction, DNA damage and numerous other signals. One gene under transcriptional control of Tup1-Ssn6 is FL01, which encodes a lectin-like cell wall protein known as a flocculin. FL01 Is a model for gene regulation in the context of chromatin. The current model for Tup1-Ssn6-mediated repression dictates that Tup1p promotes repression, while Ssn6p acts as an adaptor between Tup1 and the target gene. The aim of this project is to (i) elucidate the contribution of the Tup1p and Ssn6p subunits of the complex to gene repression, and (ii). Investigate Tupl-SsnS activity In the context of FLO1 gene regulation. The results will help elucidate the precise mechanism of action of gene repression by the evolutionary conserved Tup1p-Ssn6p corepressor comp...
http://hdl.handle.net/2262/90037
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p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis.
(2019)
Budanov, Andrei
p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis.
(2019)
Budanov, Andrei
Abstract:
SESTRINs (SESN1-3) are proteins encoded by an evolutionarily conserved gene family that plays an important role in the regulation of cell viability and metabolism in response to stress. Many of the effects of SESTRINs are mediated by negative and positive regulation of mechanistic target of rapamycin kinase complexes 1 and 2 (mTORC1 and mTORC2), respectively, that are often deregulated in human cancers where they support cell growth, proliferation, and cell viability. Besides their effects on regulation of mTORC1/2, SESTRINs also control the accumulation of reactive oxygen species, cell death, and mitophagy. SESN1 and SESN2 are transcriptional targets of tumor suppressor protein p53 and may mediate tumor suppressor activities of p53. Therefore, we conducted studies based on a mouse lung cancer model and human lung adenocarcinoma A549 cells to evaluate the potential impact of SESN1 and SESN2 on lung carcinogenesis. While we observed that expression of SESN1 and SESN2 is often decreas...
http://hdl.handle.net/2262/91605
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Evaluating social value in social clauses: Tensions in public procurement regulation and horizontal considerations
(2020)
Halloran, Deirdre
Evaluating social value in social clauses: Tensions in public procurement regulation and horizontal considerations
(2020)
Halloran, Deirdre
Abstract:
EVALUATING SOCIAL VALUE IN SOCIAL CLAUSES: TENSIONS IN PUBLIC PROCUREMENT REGULATION AND HORIZONTAL CONSIDERATIONS Public procurement and how it is regulated is an area of great economic interest. In the European Union, total public expenditure on goods, works and services amounted to over € 2,015 billion in 2015. The primary objective of EU public procurement regulation is market access and the abolition of barriers and obstacles to trade. This thesis focuses on another objective, the harnessing of public procurement’s economic power to promote social objectives and create social value. This objective is situated at the nexus of a number of politically divisive topics within the EU: the role of the state vis-à-vis the market; the concepts of competition, efficiency and value for money within regulation and policy; the position of social considerations within Europe's internal market and the limits on the discretion of Member States in implementing social policy. The thesis exa...
http://hdl.handle.net/10379/16223
Marked
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Party regulation and democratisation: challenges for further research
(2008)
McMenamin, Iain
Party regulation and democratisation: challenges for further research
(2008)
McMenamin, Iain
http://doras.dcu.ie/2194/
Marked
Mark
Next Door they have Regulation, but not here …: Assessing the Opinions of Actors in the Opaque World of Unregulated Lobbying
(2008)
Hogan, John
Next Door they have Regulation, but not here …: Assessing the Opinions of Actors in the Opaque World of Unregulated Lobbying
(2008)
Hogan, John
Abstract:
The lobbying of government by various interests is regarded as central to the democratic process. Deliberative democratic theorists tell us that the regulation of lobbying has a positive effect on political systems, and the behaviour of those within them. Yet, only a small number of democracies have implemented legislation regulating lobbyists’ activities. Even within these countries, certain jurisdictions still have not enacted lobbying regulations. Here we examine the attitudes of actors in these unregulated provinces, states and institutions towards the idea of lobbying legislation. This ensures that in the broader context the actors we deal with have knowledge of lobbying regulations, and what these regulations entail, as well as the consequences of the absence of such regulations for their jurisdictions. Our objective is to discover if these actors see benefits in the introduction of lobbying legislation, as is suggested by deliberative democratic theory, or, are they perfectly...
https://arrow.dit.ie/buschmarart/15
Marked
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Promoting Children’s Interests on the Internet: Regulation and the Emerging Evidence Base of Risk and Harm
(2010)
O'Neill, Brian; Livingstone, Sonia
Promoting Children’s Interests on the Internet: Regulation and the Emerging Evidence Base of Risk and Harm
(2010)
O'Neill, Brian; Livingstone, Sonia
Abstract:
Advocacy for child protection online has tended to flow against the tide of a dominant liberal discourse concerning the internet which posits that either the internet should not be regulated or that it can’t actually be regulated at all. Regulatory trends in Great Britain, in Europe and in the wider international arena have promoted models of co- or self-regulation whereby industries themselves with varying degrees of partnership or oversight by relevant state agencies practice ‘light-touch’ regulation based on codes established within industry fora with minimalist prescriptions on content and with ultimate responsibility for risk exposure shifted to the end user. The dominant discourse of this regulatory approach is framed both within an economic logic which argues that impediments placed in the way of an emerging new media ecology will have negative consequences for competitiveness and economic development as well as within a libertarian framework that gives primacy to adult right...
https://arrow.dit.ie/aaschmedcon/17
Marked
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The regulation of cellular CD23 gene expression by Epstein-Barr virus latent proteins in immortalised cells
(1996)
Power, Carol Mary
The regulation of cellular CD23 gene expression by Epstein-Barr virus latent proteins in immortalised cells
(1996)
Power, Carol Mary
Abstract:
Only EBV-infected B lymphocytes which express the B cell activation marker CD23 are capable of establishing immortalised cell lines. Epstein-Barr virus determined nuclear antigen 2 (EBNA-2) is essential for EBV-induced growth transformation (Cohen, et al, 1989) and can specifically upregulate CD23 gene expression (Wang, et al, 1987). The regulation of CD23 gene expression is likely to be an important factor in EBV-induced B cell growth transformation. The cellular CD23 promoter and EBV TP-1 promoter have previously been shown to be transactivated by EBNA-2 (Wang, et al, 1991, Le Roux, et al, 1993). Studies have also shown that while EBNA-3A itself has no effect on the TP-1 promoter, it can repress EBNA-2-mediated transactivation in a B cell background (Le Roux, et al, 1994). Homologies have been shown between sequences present in the EBV TP-1 EBNA-2 responsive element and other functionally similar sequences which are found in the CD23 promoter region. The purpose of this study was ...
http://doras.dcu.ie/19277/
Marked
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Regulation of CD3 expression in a protein kinase C isozyme-deficient T-cell line
(1993)
KELLEHER, DERMOT P; LONG, AIDEEN
Regulation of CD3 expression in a protein kinase C isozyme-deficient T-cell line
(1993)
KELLEHER, DERMOT P; LONG, AIDEEN
Abstract:
peer-reviewed
Using the T-cell lymphoma line HuT 78, and a clone derived from HuT 78, designated K-4, the role of protein kinase C (PKC) isozymes in the expression of a variety of T-cell surface antigens was investigated. HuT 78 expresses PKC isozymes alpha and beta while K-4 expresses only PKC alpha. Flow cytometric analysis revealed that incubation of HuT 78 cells with phorbol 12-myristate 13-acetate (PMA) results in significant down-regulation of surface expression of CD3. While K-4 cells expressed reduced amounts of CD3, a similar reduction in CD3 expression was not observed when these cells were stimulated with PMA. The regulation of expression of CD11a (LFA-1), CD44, CD45RA and CD45RO and of the class II molecules DR and DP in response to PMA, was similar in both cell lines.
http://hdl.handle.net/2262/34391
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Study of shear force as a distance regulation mechanism for scanning near-field optical microscopy
(1996)
SHVETS, IGOR
Study of shear force as a distance regulation mechanism for scanning near-field optical microscopy
(1996)
SHVETS, IGOR
Abstract:
Results of the investigation into the suitability of the shear?force distance regulation mechanism for scanning near?field optical microscopy (SNOM) are presented. It is shown that there is a range of relative sizes of surface features to tip size that gives rise to malfunctions of the shear?force distance regulation mechanism. If the size of the tip is comparable to the size of any depressions on the sample, the corresponding shear?force image may show contrast reversal. It is also shown that the resolution obtained when imaging a surface with the shear?force scanning microscope may differ for the two perpendicular lateral directions. The resolution along the oscillation axis is usually lower than the one perpendicular to it. This has implications for SNOM images. Therefore, the interpretation of shear force, and hence SNOM images, may become complex when imaging any sample with significant surface roughness.
http://hdl.handle.net/2262/40478
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Mechano-regulation of mesenchymal stem cell differentiation and collagen organisation during skeletal tissue repair
(2009)
KELLY, DANIEL; NAGEL, THOMAS
Mechano-regulation of mesenchymal stem cell differentiation and collagen organisation during skeletal tissue repair
(2009)
KELLY, DANIEL; NAGEL, THOMAS
Abstract:
A number of mechano-regulation theories have been proposed that relate the differentiation pathway of mesenchymal stem cells (MSCs) to their local biomechanical environment. During spontaneous repair processes in skeletal tissues, the organisation of the extracellular matrix is a key determinant of its mechanical fitness. In this paper, we extend the mechano-regulation theory proposed by Prendergast et al. (J Biomech 30(6):539?548, 1997) to include the role of the mechanical environment on the collagen architecture in regenerating soft tissues. A large strain anisotropic poroelastic material model is used in a simulation of tissue differentiation in a fracture subject to cyclic bending (Cullinane et al. in J Orthop Res 20(3):579?586, 2002). The model predicts non-union with cartilage and fibrous tissue formation in the defect. Predicted collagen fibre angles, as determined by the principal decomposition of strain- and stress-type tensors, are similar to the architecture seen in nati...
http://hdl.handle.net/2262/41228
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New insights into the regulation of TLR signaling
(2006)
O'NEILL, LUKE ANTHONY JOHN
New insights into the regulation of TLR signaling
(2006)
O'NEILL, LUKE ANTHONY JOHN
Abstract:
peer-reviewed
Toll-like receptor (TLR) activation is dictated by a number of factors including the ligand itself and the localization of the receptor, in terms of expression profile and subcellular localization and the signal transduction pathway that has been activated. Recent work into TLR signal transduction has revealed complex regulation at a number of different levels including regulation by phosphorylation, targeted degradation, and sequestration of signaling molecules. Here, we describe recent advances that have been made in our understanding of how TLR signaling is regulated at the biochemical level.
http://hdl.handle.net/2262/33443
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Estrogen regulation of the Potassium Channel KCNQ1:KCNE3 in Colonic Epithelium
(2013)
Rapetti-Mauss, Raphael
Estrogen regulation of the Potassium Channel KCNQ1:KCNE3 in Colonic Epithelium
(2013)
Rapetti-Mauss, Raphael
Abstract:
<p><strong>Background:</strong> The KCNQ1:KCNE3 K+ channel is an essential component of the Cl" secretion machinery in the distal colon. This channel provides the driving force for apical Cl’ secretion by basolateral recycling of K+. The steroid hormone estrogen (17|3-estradiol, E2) has previously been reported to exert a female specific antisecretory response in colonic crypts through the inhibition of the KCNQ1:KCNE3 channel. The purpose of this study was to uncover and describe molecular mechanisms of estrogen regulation of KCNQ1 channel function and its consequences for intestinal Cl' secretion, colonocyte proliferation and migration. The thesis reveals a novel estrogen regulation of KCNQ1:KCNE3 activity by channel endocytosis and complex dissociation.</p> <p><strong>Methods:</strong> Isolated rat colonic crypts as well as the colonic cell line HT29cll9A (HT29) were used to investigate estrogen effects on Cl' secretion and...
https://epubs.rcsi.ie/phdtheses/116
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Mark
The Conceptual and Constitutional Challenge of Transnational Private Regulation
(2015)
Scott, Colin; Cafaggi, Fabrizio; Senden, Linda
The Conceptual and Constitutional Challenge of Transnational Private Regulation
(2015)
Scott, Colin; Cafaggi, Fabrizio; Senden, Linda
Abstract:
Transnational private regulation (TPR) is a key aspect of contemporary governance. At first glance TPR regimes raise significant problems of legitimacy because of a degree of detachment from traditional government mechanisms. A variety of models have emerged engaging businesses, associations of firms, and NGOs, sometimes in hybrid form and often including governmental actors. Whilst the linkage to electoral politics is a central mechanism of legitimating governance activity, we note there are also other mechanisms including proceduralization and potentially also judicial accountability. But these public law forms do not exhaust the set of such mechanisms, and we consider also the contribution of private law forms and social and competitive structures which may support forms of legitimation. The central challenge identified concerns the possibility of reconceptualizing the global public sphere so as better to embrace TPR regimes in their myriad forms, so that they are recognized as h...
http://hdl.handle.net/10197/6765
Marked
Mark
A comparison of the effects of decommissioning, catch quotas and mesh regulation in restoring a depleted fishery.
(2011)
Hillis, J. Paul; Wiium, Vilhjalmur
A comparison of the effects of decommissioning, catch quotas and mesh regulation in restoring a depleted fishery.
(2011)
Hillis, J. Paul; Wiium, Vilhjalmur
Abstract:
Possible means of rehabilitating the manY depleted fisheries in European waters now form a topic of great interest and relevance. This paper uses bioeconomic analysis to predict returns for the Irish Sea Nephrops fishery from rationalisation through three types of management regulations. These regulation measures are (a) decommissioning. i.e., reducing fleet size, (b) catch quotas while maintaining fleet size, and (c) mesh size regulation. The analysis clearly demonstrates the gains to be obtained from rationalising the Nephrops fishery. In addition. socio-economic implications of performance of the fisheries compared to potential profitability is extremely poor. Substantially improved returns would result frmn strong management control. However, trying to preserve social equity, while theoretically possible, would necessitate complicated cunstraints to the operation of the management system.
http://hdl.handle.net/10379/1666
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