rian.ie - Results

A A A

Current Search:	'regulation' in all fields;

Displaying Results 76 - 100 of 3498 on page 4 of 140

Mark

Hemodynamic regulation of MMP-2 and MMP-9: roles in angiogenesis and migration (2004)

Von Offenberg Sweeney, Nicholas

Mark

Effect of surgery and endotoxin on metastatic tumor growth and regulation of VEGF expression and angiogenesis by endotoxin (2001)

Pidgeon, Graham

Mark

Investigation of lantibiotic regulation, immunity and synergy (2014)

Draper, Lorraine A.

Mark

The regulation of Krox-20 expression reveals important steps in the control of peripheral glial cell development. (1996)

MURPHY, PAULA

Mark

Epigenetics Underpinning the Regulation of the CXC (ELR+) Chemokines in Non-Small Cell Lung Cancer (2011)

O'BYRNE, KEN; BAIRD, ANNE-MARIE; GRAY, STEVEN

Mark

A Mechano-Regulation Model of Fracture Repair in Vertebral Bodies (2010)

KELLY, DANIEL

Mark

Mechano-regulation of stem cell differentiation and tissue regeneration in osteochondral defects (2005)

KELLY, DANIEL; PRENDERGAST, PATRICK JOHN

Mark

The tenement homes of Dublin: their condition and regulation (1899)

Eason, Charles

Mark

The Alert Programme for Self Regulation - an evaluation of a group based intervention for children attending a child and adolescent mental health clinic (2011)

CREMIN, KATIE

Mark

Experimental validation of CFD modelling for thermal regulation o photovoltaic panels using phase change material (2011)

Sarwar, SARAH; MC CORMACK; Huang; Norton

Mark

Differential filamentation of Candida albicans and C. dubliniensis is governed by nutrient regulation of UME6 expression (2010)

SULLIVAN, DEREK; MORAN, GARY

Mark

Counter-regulation in the IKK family. (2011)

O'NEILL, LUKE

Mark

Substrate-Promoted Formation of a Catalytically Competent Binuclear Center and Regulation of Reactivity in a Glycerophosphodiesterase from Enterobacter aerogenes (2008)

Hadler, Kieran S.; Tanifum, Eric A.; Hsu-Chen Yip, Sylvia; Mitic, Natasa; Guddat, Luke ...

Substrate-Promoted Formation of a Catalytically Competent Binuclear Center and Regulation of Reactivity in a Glycerophosphodiesterase from Enterobacter aerogenes (2008)

Hadler, Kieran S.; Tanifum, Eric A.; Hsu-Chen Yip, Sylvia; Mitic, Natasa; Guddat, Luke W.; Jackson, Colin J.; Gahan, Lawrence R.; Nguyen, Kelly; Carr, Paul D.; Ollis, David L.; Hengge, Alvan C.; Larrabee, James A.; Schenk, Gerhard

Abstract:

The glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes is a promiscuous binuclear metallohydrolase that catalyzes the hydrolysis of mono-, di-, and triester substrates, including some organophosphate pesticides and products of the degradation of nerve agents. GpdQ has attracted recent attention as a promising enzymatic bioremediator. Here, we have investigated the catalytic mechanism of this versatile enzyme using a range of techniques. An improved crystal structure (1.9 Å resolution) illustrates the presence of (i) an extended hydrogen bond network in the active site, and (ii) two possible nucleophiles, i.e., water/hydroxide ligands, coordinated to one or both metal ions. While it is at present not possible to unambiguously distinguish between these two possibilities, a reaction mechanism is proposed whereby the terminally bound H2O/OH- acts as the nucleophile, activated via hydrogen bonding by the bridging water molecule. Furthermore, the presence of substrate promotes th...