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'regulation' in all fields;
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Displaying Results 76 - 100 of 3876 on page 4 of 156
Marked
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Report on the regulation of practitioners of complementary and alternative medicine in Ireland.
(2002)
O'Sullivan, Tim
Report on the regulation of practitioners of complementary and alternative medicine in Ireland.
(2002)
O'Sullivan, Tim
Abstract:
This is a period of growing interest in issues related to Complementary and Alternative Medicine (CAM) and its regulation. This report has been written in the context of this interest and in response to a request from the Department of Health and Children. It follows a Forum on regulatory issues that was held at the IPA in June 200I and attended by many CAM practitioners. The Minister for Health and Children asked the Institute to build on the discussions at the Forum by preparing a report on possible options in the regulation of CAM practitioners in Ireland. The focus of the report is on regulatory and policy issues in general. It is not within the Institute's competence or brief to comment on more specific clinical or technical issues. CAM therapies are extremely varied and complex and are practised by a very wide range of practitioners so it would be very difficult to find a totally satisfactory, all-encompassing definition. Paragraph 1.2 sets out various current definitions.
http://hdl.handle.net/10147/575424
Marked
Mark
Report on the regulation of complementary and alternative practitioners in Ireland.
(2002)
O'Sullivan, Tim
Report on the regulation of complementary and alternative practitioners in Ireland.
(2002)
O'Sullivan, Tim
Abstract:
This is a period of growing interest in issues related to Complementary and Alternative Medicine (CAM) and its regulation. This report has been written in the context of this interest and in response to a request from the Department of Health and Children. It follows a Forum on regulatory issues that was held at the IPA in June 2001 and attended by many CAM practitioners. The Minister for Health and Children asked the Institute to build on the discussions at the Forum by preparing a report on possible options in the regulation of CAM practitioners in Ireland. The focus of the report is on regulatory and policy issues in general. It is not within the Institute's competence or brief to comment on more specific clinical or technical issues.
http://hdl.handle.net/10147/575446
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Regulation of the immunomodulatory cytokine IL-10 by Twist2
(2014)
Van den Bosch, Mirjam W. M.
Regulation of the immunomodulatory cytokine IL-10 by Twist2
(2014)
Van den Bosch, Mirjam W. M.
Abstract:
THESIS 10518
Dysregulation of cytokines can lead to infectious and inflammatory diseases. The anti-inflammatory cytokine IL-10 is known to control pro-inflammatory cytokines such as TNF-a, IL-6 and IL-12. The regulation of IL-10 is complex and it has been shown previously that the human tumour suppressor PDCD4 is a negative regulator of IL-10 production. Following LPS stimulation, PDCD4 acts as a molecular switch whereby its degradation results in increased IL-10 production. In this study, I have examined in detail the regulation of PDCD4 in LPS- treated macrophages. I have shown that the mTOR pathway and proteosomal degradation are involved in LPS- induced PDCD4 degradation using rapamycin, an mTOR inhibitor, or the proteosomal inhibitors MG132, both of which block this response. Inhibition of PDCD4 degradation by rapamycin also decreased IL-10 and c-Maf expression, a transcription factor critical for IL-10 induction. I have alson found evidence through immunoprecipitation, of ...
http://hdl.handle.net/2262/80533
Marked
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Regulation of bovine beta-defensin expression
(2017)
Barry-Reidy, Anne
Regulation of bovine beta-defensin expression
(2017)
Barry-Reidy, Anne
Abstract:
Beta-defensins are a class of host defence peptides with antibacterial, antiviral and immunomodulatory roles. The bovine genome contains up to 57 putative beta-defensin genes in four syntenic clusters on different chromosomes. The regulation of expression of these pleiotropic molecules is still poorly explored. As beta-defensins are involved in bovine fertility, the overall aim of this project was to investigate the regulation of expression of beta-defensins in this context. We have bioinformatically analysed the proximal promoter regions of chromosome 13 beta-defensin genes from the bovine and other mammals to identify potential regulators of gene transcription for further investigation. Transcription factor binding site over-representation analysis of a beta-defensin cluster which is highly expressed in the male reproductive tract indicates enrichment of DNA binding sites for transcription factors important in regulating gene expression at this site. These include androgen recept...
http://hdl.handle.net/2262/81726
Marked
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Policing the press: the institutionalisation of independent press regulation in a liberal/north Atlantic media system
(2017)
Dunne, Stephen
Policing the press: the institutionalisation of independent press regulation in a liberal/north Atlantic media system
(2017)
Dunne, Stephen
Abstract:
In each of the media systems identified by Hallin and Mancini (2004), autonomy, professional norms and a public service ethic are central indicators of journalism professionalisation, with codes of ethics and accountability solutions, such as press councils, germane. In the Liberal North Atlantic system, where Ireland is placed by Hallin and Mancini, autonomy and professional norms are well established pillars in academia’s understanding of journalism. Indeed, the theoretical work on press and media systems (Siebert, Peterson and Schramm 1956; Merrill 1974; Altschull 1984; Habermas 1989; McQuail 2010) recognises these characteristics. The idea of a public service orientation via a system of media accountability opens up a potentially valuable avenue for examining the journalistic professionalisation process. In Liberal North Atlantic countries, non-institutionalised or informal self-regulation of the press is common, Hallin and Mancini argued. The literature, however, suggests this ...
http://doras.dcu.ie/21957/
Marked
Mark
A role for microRNA-21 in the regulation of gastrointestinal health and disease
(2017)
Johnston, Daniel
A role for microRNA-21 in the regulation of gastrointestinal health and disease
(2017)
Johnston, Daniel
Abstract:
THESIS 11478
The gastrointestinal (GI) tract is a crucial site of innate and adaptive immune regulation, balancing tolerance of beneficial commensal microorganisms and reaction to invading pathgens. Pattern recognition receptors (PRRs), including Toll-like receptors (TLRs), are vital sensors in the orchestration of these immune responses to maintain intestinal homeostasis. Furthermore, these responses must be tightly regulated to ensure an appropriate level of response. There are multiple classes of regulators including non-coding RNA microRNAs which regulate mRNA expression. In this project, we sought to explore the role of microRNA-21 (miR-21) in intestinal health and disease. miR-21 is considered to be an anti-inflammatory regulator in various contexts in immunity, with the negative regulation of TLR4 signalling being of particular interest. However, it has also been shown to be deleterious in cancer and its expression is elevated in patients with several inflammatory disease...
http://hdl.handle.net/2262/85223
Marked
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Transcriptional Regulation and Epigenetics in Cardiovascular Cells: Role of the Mineralocorticoid Receptor
(2019)
Deng, Lisa; Hein, Lutz; Lother, Achim
Transcriptional Regulation and Epigenetics in Cardiovascular Cells: Role of the Mineralocorticoid Receptor
(2019)
Deng, Lisa; Hein, Lutz; Lother, Achim
Abstract:
<p>The original book chapter is available at https://www.intechopen.com/</p>
<p>The mineralocorticoid receptor (MR), a ligand-activated transcription factor, plays an important role in the pathophysiology of cardiovascular disease. Epigenetic mechanisms such as DNA methylation or histone modifications in addition to the DNA sequence are decisive regulators of cell type-specific transcriptional activity and gene expression by controlling chromatin accessibility. In this review, we summarise the current knowledge about the impact of MR on gene expression in cardiovascular cells. We discuss studies investigating the interaction of MR with epigenetic mechanisms or other transcription factors and their implications for the cardiovascular system. Finally, we compare mechanisms of transcriptional regulation by MR and other nuclear transcription factors. In conclusion, MR is an important regulator of gene expression in cardiovascular cells. Potential mechanisms of cell...
https://epubs.rcsi.ie/molmedart/55
Marked
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Individual Blade Pitch Control of Floating Offshore Wind Turbines for Load Mitigation and Power Regulation
(2020)
Fitzgerald, Breiffni; Basu, Biswajit; Sarkar, Saptarshi
Individual Blade Pitch Control of Floating Offshore Wind Turbines for Load Mitigation and Power Regulation
(2020)
Fitzgerald, Breiffni; Basu, Biswajit; Sarkar, Saptarshi
Abstract:
This paper proposes a new strategy for individual blade pitch control to regulate power production while simultaneously alleviating structural loads on spar-type floating offshore wind turbines. Individual blade pitch control types of algorithms for offshore wind turbines are sparse in the literature though there are expected benefits from experience on such types of controllers for onshore wind turbines. Wind turbine blade pitch actuators are primarily used to maintain rated power production at above-rated wind speeds and therefore, control algorithms are usually developed only to regulate power production. The scope of reducing structural loads using individual pitch control has been proved to be very promising over the last decade and numerous individual pitch control algorithms have been proposed by researchers. However, reduction in structural loads often results in a degradation in power production and regulation. Furthermore, improving power regulation often has a detrimental...
http://hdl.handle.net/2262/91667
Marked
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The New General Block Exemption Regulation and the Rights of Persons with Disabilities: Smoke without Fire?
(2015)
Ferri, Delia
The New General Block Exemption Regulation and the Rights of Persons with Disabilities: Smoke without Fire?
(2015)
Ferri, Delia
Abstract:
This article examines Commission Regulation (EU) N°651/2014 declaring certain categories of aid compatible with the internal market in application of Articles 107 and 1o8 of the Treaty, better known as 2014 General Block Exemption Regulation (GBER) vis-a-vis the United Nations Convention on the Rights of Persons with Disabilities (UNCRPD). In particular, it frames the GBER within the context of the European disability policy and discusses whether the new GBER complies with the international obligations that the EU has undertaken by concluding the UNCRPD. This article focuses on the GBER provisions concerning aid to employment and training of workers with disabilities and aid compensating for the additional costs of employing workers with disabilities, comparing and contrasting them with those included in the former 2oo8 GBER. It also comments on the GBER sections related to training aid and to aid for culture and heritage conservation. Both sections contain explicit references to pe...
http://mural.maynoothuniversity.ie/11713/
Marked
Mark
New insights into the regulation of TLR signaling
(2006)
Miggin, Sinead; O'Neill, Luke A.J.
New insights into the regulation of TLR signaling
(2006)
Miggin, Sinead; O'Neill, Luke A.J.
Abstract:
Toll-like receptor (TLR) activation is dictated by a number of factors including the ligand itself and the localization of the receptor, in terms of expression profile and subcellular localization and the signal transduction pathway that has been activated. Recent work into TLR signal transduction has revealed complex regulation at a number of different levels including regulation by phosphorylation, targeted degradation, and sequestration of signaling molecules. Here, we describe recent advances that have been made in our under- standing of how TLR signaling is regulated at the biochemical level.
http://mural.maynoothuniversity.ie/12629/
Marked
Mark
Regulating havens: the role of hard and soft governance of tax experts in conditions of secrecy and low regulation
(2020)
Killian, Sheila; O'Regan, Philip; Lynch, Ruth; Laheen, Martin; Karavidas, Dionysios
Regulating havens: the role of hard and soft governance of tax experts in conditions of secrecy and low regulation
(2020)
Killian, Sheila; O'Regan, Philip; Lynch, Ruth; Laheen, Martin; Karavidas, Dionysios
Abstract:
International tax governance is significant societally as it impacts both inequality and the capacity of governments to deliver on their social contracts. Tax experts forma key, under-researched, heterogeneous element of the tax ecosystem, subject to a range of hard and soft governance influences. While problematic tax regimes are appropriately identified by reference to lax regulation or financial opacity, few empirical studies explore how operating in these jurisdictions affects the governance of tax experts individually. Using international survey data, we find that the influence of soft governance on tax experts varies across conditions of secrecy or lax regulation. Soft governance, including that of the workplace and the profession, is most influential in challenging regimes. Beyond a tipping point of economic freedom, regulatory knowledge and the threat of sanction become less influential. Elements along the continuum between hard and soft governance interact in a non-homogeno...
http://hdl.handle.net/10344/9022
Marked
Mark
Discourse and religious doctrine: Professional social work and the moral regulation of the body in Roman Catholic Ireland
(2020)
Flynn, Susan
Discourse and religious doctrine: Professional social work and the moral regulation of the body in Roman Catholic Ireland
(2020)
Flynn, Susan
Abstract:
The moral and practical regulation of sexuality and associated risk has been traditionally bound by Catholic religious doctrine in the Republic of Ireland. Over the last century, however, the emergence of professional social work as a state risk management strategy around sexuality is evident. This tallies with the disrepute of the Church following high-profile abuse scandals and publicized tragedies tied to institutional segregation. This paper presents theoretically informed critical commentary, through uptake of the Foucauldian notion of discourse. It concludes that critique of the regulation of sexuality, should be qualified on three counts. Firstly, tensions between Catholicism and social work remain. Secondly, wariness toward the operation of power is requisite. Thirdly, both that which is said, and unsaid, enlightens present debates.
http://hdl.handle.net/2262/93732
Marked
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Evaluation of Phase Change Materials for Thermal Regulation Enhancement of Building Integrated Photovoltaics
(2010)
Hasan, A.; McCormack, Sarah; Huang, M.; Norton, Brian
Evaluation of Phase Change Materials for Thermal Regulation Enhancement of Building Integrated Photovoltaics
(2010)
Hasan, A.; McCormack, Sarah; Huang, M.; Norton, Brian
Abstract:
Regulating the temperature of building integrated photovoltaics (BIPV) using phase change materials (PCMs) reduces the loss of temperature dependent photovoltaic (PV) efficiency. Five PCMs were selected for evaluation all with melting temperatures 25 ± 4 C and heat of fusion between 140 and 213 kJ/kg. Experiments were conducted at three insolation intensities to evaluate the performance of each PCM in four different PV/PCM systems. The effect on thermal regulation of PV was determined by changing the (i) mass of PCM and (ii) thermal conductivities of the PCM and PV/PCM system. A maximum temperature reduction of 18 C was achieved for 30 min while 10 C temperature reduction was maintained for 5 h at 1000 W/m2 insolation.
https://arrow.dit.ie/dubenart/37
Marked
Mark
Female sexuality in Ireland 1920 to 1940: Construction and regulation
(1999)
Leane, Máire
Female sexuality in Ireland 1920 to 1940: Construction and regulation
(1999)
Leane, Máire
Abstract:
The central objective of this study is an examination of discourses of Irish female sexuality and of the apparatuses of control designed for its surveillance and regulation in the period nineteen-twenty to nineteen-forty. It is argued that during this period sexuality, and in particular female sexuality, became established as an icon of national identity. This thesis demonstrated that this identity was given symbolic embodiment in the discursive construction of an idealised, feminine subject, a subject who had purity and sexual morality as her defining characteristics. It is argued that female roles and in particular female sexuality, emerged as contested issues in post-colonial Ireland. This is not unusual given that women are frequently constructed in nationalist discourses as repositories of cultural heritage and symbols of national identity (Kandiyoti 1993). This thesis demonstrates that the Catholic Church played a central role in this process of establishing female sexuality a...
http://hdl.handle.net/10468/545
Marked
Mark
The impact of carbohydrate ingestion on the regulation of fat oxidation following exercise
(2007)
Sarsfield, Fiona
The impact of carbohydrate ingestion on the regulation of fat oxidation following exercise
(2007)
Sarsfield, Fiona
Abstract:
Purpose: To determine the impact of carbohydrate (CHO)ingestion on the regulation of fat oxidation following glycogen lowering exercise. Methods: Six males (age 23.4 2 1.7y, vo2peak 58.0 2 2.1 ml.kg-'.min-') participated in the study. Subjects performed an incremental maximal cycle ergometer test and a verification trial to determine the workload corresponding to 75%V02peak. On separate days, subjects exercised at 75% vO2peak for 90 min. Following exercise, subjects consumed either a CHO drink or a flavoured placebo (PLA). Substrate oxidation was measured for I h after exercise using indirect calorimetry. Before, immediately after, and A h after exercise, subjects had a muscle biopsy taken from the vastus lateralis. Results: Subjects exercised at a similar %VO2peak during both the CHO (71.5 2 I -8% v02peak) and the PLA (72.5 2 1.8%VO2peak) trials. Energy expended during and following exercise was similar between trials. The contribution of fat towards energy expenditure ...
http://doras.dcu.ie/16966/
Marked
Mark
Institutional change and conflict regulation : the Anglo-Irish Agreement (1985) and the mechanisms of change in Northern Ireland
(2010)
Todd, Jennifer
Institutional change and conflict regulation : the Anglo-Irish Agreement (1985) and the mechanisms of change in Northern Ireland
(2010)
Todd, Jennifer
Abstract:
The mechanisms of institutional change identified in comparative studies of industrial policy and welfare state development are also to be found in processes of intergovernmental ethnic conflict regulation. This article shows how the 1985 Anglo-Irish Agreement set in place a very thin layer of intergovernmental institutions which started an institutional momentum, opening new political opportunities, changing political expectations, and thus paving the way for the much more radical political and institutional changes that were to follow. It uses new data to show how the elites who initiated the process conceived of it and to identify the mechanisms producing change.
Not applicable
Irish Research Council for the Social Sciences
ti, ke, ab, sp - AL 27/07/2010
http://hdl.handle.net/10197/2372
Marked
Mark
Hemodynamic regulation of occludin and ZO-1: effect on barrier function
(2006)
Collins, Nora
Hemodynamic regulation of occludin and ZO-1: effect on barrier function
(2006)
Collins, Nora
Abstract:
The vascular endothelium constitutes a highly effective fluid and solute barrier through the regulated apposition of tight junction protein complexes between adjacent endothelial cells. As endothelial cell-mediated functions and pathology are sensitive to hemodynamic forces (cyclic strain and shear stress), we hypothesised a dynamic regulatory link between endothelial tight junction assembly/function and hemodynamic stimuli. We have investigated this hypothesis via examination of the precise effects of cyclic strain on the expression, modification, and function o f occludin and ZO-1, pivotal components o f the tight junction complex. Moreover, the mechanotransduction pathway by which tight junction regulation occurs was also investigated. For these studies, cultured bovine aortic endothelial cells (BAECs) were subjected to physiological levels o f equibiaxial cyclic strain (0 or 5% strain, 60 cycles/min, 24 h). In response to strain, protein expression o f both occludin and ZO-1 i...
http://doras.dcu.ie/17374/
Marked
Mark
Hemodynamic regulation of metalloendopeptidases EC3.4; 24.15 and EC3.4; 24.16: expression and function in the vascular endothelium
(2005)
Cotter, Eoin J.
Hemodynamic regulation of metalloendopeptidases EC3.4; 24.15 and EC3.4; 24.16: expression and function in the vascular endothelium
(2005)
Cotter, Eoin J.
Abstract:
Hemodynamic forces, namely shear stress and cyclic strain, have been well characterised as modulators of vascular endothelial function, and have been assigned an important role in the maintainence of vascular tone, haemostasis, and regulation of vascular growth and health. They exert their influence in part by effecting changes in the production and release of vasoactive compounds by the endothelium, and by effecting changes in the levels and activity of various enzymes. Thimet oligopeptidase (EC3.4.24.15, EP24.15) and neurolysin (EC3.4.24.16, EP24.15) are closely related zinc metalloendopeptidases that have been shown to be expressed and active in the vascular endothelium. Their substrates include the vasoactive peptides bradykinin and angiotensin I, which have been identified as important regulators of both blood pressure and angiogenic processes. Other related peptidases, namely endothelin converting enzyme (ECE) and angiotensin converting enzyme (ACE), have been shown to be regu...
http://doras.dcu.ie/17283/
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Goals, adaptive self-regulation, and psychosocial adjustment to lower limb amputation: A longitudinal study
(2012)
Coffey, Laura
Goals, adaptive self-regulation, and psychosocial adjustment to lower limb amputation: A longitudinal study
(2012)
Coffey, Laura
Abstract:
Lower limb amputation is a life-changing event that can cause significant disruptions in many important areas of existence. Although a substantial minority of individuals suffer from emotional difficulties following this procedure, most adapt successfully to the losses and limitations incurred, with some achieving positive change and growth as a result. According to self-regulation theory, the physical, social and psychological upheaval caused by amputation is likely to disturb progress towards goal attainment, which may leave individuals vulnerable to negative psychosocial outcomes if they do not regulate their goals in response to these challenges. The aim of the present study was to examine the relationships between goal disturbance, tenacious goal pursuit (TGP), flexible goal adjustment (FGA), and various positive and negative psychosocial outcomes (participation, positive and negative affect, quality of life, psychosocial adjustment to amputation, depressive symptomatology) in...
http://doras.dcu.ie/17443/
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Social regulation, medicalisation and the nurse's role: insights from an analysis of nursing documentation
(2013)
Hyde, Abbey; Treacy, Margaret P.; Scott, Anne P.; MacNeela, Padraig; Butler, Michelle; ...
Social regulation, medicalisation and the nurse's role: insights from an analysis of nursing documentation
(2013)
Hyde, Abbey; Treacy, Margaret P.; Scott, Anne P.; MacNeela, Padraig; Butler, Michelle; Drennan, Jonathan; Irving, Kate; Byrne, Anne
Abstract:
Background: Medicine is recognised as a dominant source of governmentality and social regulation, and although nursing has been implicated in the same process, analytical work in this area has been sparse. Objectives: The article aims to present an analysis of nursing records in order to understand the structural and social processes that mediate the texts. Methods: 45 sets of nursing records drawn from four clinical sites in Ireland were subjected to a discourse analysis. Results: This article focuses on two main themes that were derived from data: (i) the manner in which nurses controlled, regulated and invigilated patients' activities of daily living and (ii) the way in which activities of daily living were mediated by a biomedical worldview in the clinical settings. Through the organising framework of Activities of Daily Living (ADLs), normative social practices relating to hygiene, eating and drinking, sleeping and so forth were surveyed and monitored within clinical setti...
http://hdl.handle.net/10197/4190
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Quantification and regulation of pellet morphology in streptomyces hygroscopicus var; geldanus cultures
(2005)
Ó Cléirigh, Cormac
Quantification and regulation of pellet morphology in streptomyces hygroscopicus var; geldanus cultures
(2005)
Ó Cléirigh, Cormac
Abstract:
Streptomyces hygroscopicus var. geldanus, an actinomycete, produces a range of antibiotic compounds, one of which, Geldanamycin, is currently under investigation for its potential anticancer properties. Filamentous microbes, both bacterial and fungal, possess the ability to grow in a range of morphological forms in submerged fermentations. Secondary metabolite production by filamentous microorganisms is often dependent on the morphology of biomass aggregates within the culture and therefore morphological regulation in such fermentations is desirable in order to produce specific compounds of interest. Morphological assessment of pellet formation and growth necessitated the development of an image analysis technique to allow high throughput morphological characterisation of microbial fermentation broths. An assessment of environmental and nutritional conditions for culturing S. hygroscopicus , concentrating specifically on the impact of nutrient broth composition, spore loading densi...
http://doras.dcu.ie/18112/
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Genetic regulation of iron responsive genes in sinorhizobium meliloti
(2005)
Viguier, Caroline
Genetic regulation of iron responsive genes in sinorhizobium meliloti
(2005)
Viguier, Caroline
Abstract:
Iron is an essential nutrient for most bacteria. It is a crucial metal of many metalloenzymes and functions m important biological systems mamly as the cofactor of redox enzymes Bacteria must acquire iron from the environment where the metal is mainly found in the fem e iron state, which is very insoluble. In addition, they must maintain iron homeostasis. One mechanism used by bacteria for the acquisition of iron is the production of siderophores, which are low molecular weight chelators with affinity and specificity for ferroc iron and which are formed and secreted under iron deplete conditions. The regulation of iron was studied in Sinorhizobium mehloti, which is a free-living Gram-negative bacteria found in soil and also as an endosymbiont o f Medicago sativa (alfalfa). A homologue of the ferric uptake protein (Fur), which regulates the uptake of iron in most Gram-negative bacteria, was identified and characterised However, the results suggest that in S mehloti, Fur does not fun...
http://doras.dcu.ie/18258/
Marked
Mark
Hemodynamic regulation of MMP-2 and MMP-9: roles in angiogenesis and migration
(2004)
Von Offenberg Sweeney, Nicholas
Hemodynamic regulation of MMP-2 and MMP-9: roles in angiogenesis and migration
(2004)
Von Offenberg Sweeney, Nicholas
Abstract:
Hemodynamic forces generated by the flow of blood are crucial in maintaining homeostasis within the blood vessel wall. These forces, namely cyclic strain and shear stress are intricately involved in vascular remodeling, a process which underlies the pathogenesis of cardiovascular diseases such as atherosclerosis and restenosis. Since degradation of the extracellular matrix scaffold enables reshaping of tissue, the role matrix metalloproteinases (MMPs) has become the object of intense recent interest in relation to physiological and pathological vascular remodeling. The culminating data indicates that hemodynamic forces are important regulators of MMP expression and activity. A more complete understanding of the hemodynamic regulation of MMPs may advance the understanding of pathological vascular remodeling. We have investigated the effect of cyclic strain on the endothelial cell migration and angiogenic activity and the role of gelatinases in mediating these responses We have shown...
http://doras.dcu.ie/18261/
Marked
Mark
Effect of surgery and endotoxin on metastatic tumor growth and regulation of VEGF expression and angiogenesis by endotoxin
(2001)
Pidgeon, Graham
Effect of surgery and endotoxin on metastatic tumor growth and regulation of VEGF expression and angiogenesis by endotoxin
(2001)
Pidgeon, Graham
Abstract:
The surgical removal of primary tumours has been associated with the subsequent growth of previously dormant metastases. This accelerated growth has previously been ascribed to the removal of the primary tumour and the anti-angiogenic factors they produce, such as angiostatin and endostatin. Endotoxin or lipopolysaccharide (LPS) is a cell wall constituent of gram negative bacteria, ubiquitously present in air and endogenous gut bacteria, that may be introduced during surgery. LPS has been shown to be angiogenic and vascular endothelial growth factor (VEGF) is the most potent angiogenic cytokine identified to date. The role of endotoxin in surgically induced metastatic tumour growth, the therapeutic use of anti-endotoxin agents in the perioperative period, the regulation of VEGF expression by endotoxin and the effect of VEGF and endotoxin on tumour cell survival was examined. A murine model of experimental metastasis was established where no primary tumour was present. This allowed ...
http://doras.dcu.ie/19273/
Marked
Mark
Investigation of lantibiotic regulation, immunity and synergy
(2014)
Draper, Lorraine A.
Investigation of lantibiotic regulation, immunity and synergy
(2014)
Draper, Lorraine A.
Abstract:
Due to the increasing incidence of antibiotic resistant strains, the use of novel antimicrobials, such as bacteriocins, has become an ever more likely prospect. Lacticin 3147 (of which there are two components, Ltnα and Ltnβ) and nisin belong to the subgroup of bacteriocins called the lantibiotics, which has attracted much attention in recent years. The lantibiotics are antimicrobial peptides that contain unusual amino acids resulting from a series of enzyme-mediated post translational modifications. Given that there have been relatively few examples of lantibiotic-specific resistance; these antimicrobials appear to represent valid alternatives to classical antibiotics. However, the fact that lantibiotics are naturally only produced in small amounts often hinders their commercialisation. In order to overcome this bottleneck, several approaches can be employed. For example, we can create a situation that reduces the quantity of a lantibiotic required to inhibit a target by combining ...
http://hdl.handle.net/10468/1543
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