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Displaying Results 6101 - 6125 of 6252 on page 245 of 251
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Increased response/recovery lifetimes and reinforcement of Polyaniline Nanofiber Films using Carbon Nanotubes
(2012)
COLEMAN, JONATHAN NESBIT; BLIGHE, FIONA
Increased response/recovery lifetimes and reinforcement of Polyaniline Nanofiber Films using Carbon Nanotubes
(2012)
COLEMAN, JONATHAN NESBIT; BLIGHE, FIONA
Abstract:
We have prepared high surface area, conductive, mechanically robust, responsive polyaniline-carbon nanotune composite films. These were produced by filtration from dilute dispersions of polyaniline nanofibers and single-walled carbon nanotubes. Unlike polyaniline alone, these composites are mechanically stable, maintain large intractable surfaces and exhibit greatly enhanced response/recovery behavior to changes in their local environment. This is illustrated by exposing the films to ammonia.
http://hdl.handle.net/2262/62418
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Dynamic response of ammonia sensors constructed from polyaniline nanofibre films with varying morphology
(2012)
COEY, JOHN MICHAEL DAVID; STAMENOV, PLAMEN
Dynamic response of ammonia sensors constructed from polyaniline nanofibre films with varying morphology
(2012)
COEY, JOHN MICHAEL DAVID; STAMENOV, PLAMEN
Abstract:
Polyaniline is acid-doped with HCl, HNO3, HClO4, HBr or H2SO4 to yield thin films that are nanofibrous or dense. The nanofibrous films show a faster response to ammonia gas, and the response is greater when the films are in the moderately-conducting green state than when they are in the highly-conducting yellow state. The film resistance and optical absorption spectrum are monitored at 20 ms and 500 ms intervals, respectively during and after exposure to ammonia. Three absorption processes with characteristic times of order 10 s, 100 s, and 1000 s are observed in the resistive response. The optical spectrum is fitted with three Gaussians or derived Gaussians centred in the blue, orange and infra-red which exhibit similar response times of order 100 s and 1000 s, corresponding to the longer times in the resistive response. The data are interpreted in terms of three processes, physisorption, chemisorption and structural rearrangement of the polymer chains. Gas selectivity is demonstra...
http://hdl.handle.net/2262/62422
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Stabilizing effect of a magnetic field on a gas bubble produced at a microelectrode
(2012)
MOEBIUS, MATTHIAS; COEY, JOHN MICHAEL DAVID; MEAGHER, AARON; FERNANDEZ, DAMARIS
Stabilizing effect of a magnetic field on a gas bubble produced at a microelectrode
(2012)
MOEBIUS, MATTHIAS; COEY, JOHN MICHAEL DAVID; MEAGHER, AARON; FERNANDEZ, DAMARIS
Abstract:
The effect on the growth of a single hydrogen bubble of a magnetic field oriented normal to the surface of a microelectrode is investigated. Overpotential oscillations due to periodic growth and detachment of bubbles are correlated with high-speed camera images and particle tracking was used to follow the flow pattern. The bubbles on both horizontal and vertical microelectrodes grow bigger in the field, doubling in diameter before they break away in 5 tesla. The effect is related to the influence of the magnetic field on the breakoff mechanism rather than to Ekman pumping driven by the Lorentz force.
http://hdl.handle.net/2262/62431
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Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor
(2012)
CONNOR, THOMAS JOSEPH
Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor
(2012)
CONNOR, THOMAS JOSEPH
Abstract:
The endocannabinoid system is an important regulator of the nervous, neuroendocrine and immune systems, thus representing a novel therapeutic target for stress-related neuroinflammatory and psychiatric disorders. However, there is a paucity of data relating to the effects of endocannabinoids on neuroinflammatory mediators following an immune stress/challenge in vivo. This study investigated the effects of URB597, a selective inhibitor of fatty acid amine hydrolyase (FAAH), the enzyme that preferentially metabolises anandamide, on lipopolysaccharide (LPS)-induced increases in the expression of immune mediators in the hypothalamus. Systemic administration of URB597 increased the levels of anandamide and the related N -acylethanolamines, N -palmitoyl ethanolamide and N-oleoyl ethanolamide, but not 2-arachidonoyl glycerol, in the hypothalamus and spleen. URB597 attenuated the LPS-induced increase in interleukin (IL)-1β expression while concurrently augmenting the LPS-induced increase in...
http://hdl.handle.net/2262/62415
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Determinants of Food Choice in Irish Adolescents
(2012)
SHARE, MICHELLE
Determinants of Food Choice in Irish Adolescents
(2012)
SHARE, MICHELLE
Abstract:
This study aimed to determine food choice motivations amongst adolescents using a revised Food Choice Questionnaire (FCQ). The revised FCQ was administeredtoa sample of 14-17 year olds in the Republic of Ireland and Northern Ireland (n = 397). Socio-demographic measures of gender and age were also collected. Five food choice motivation factors were discerned: health; mood; price/convenience; religion; and animal rights.The study reveals important differences between adults and adolescents in how factors such as health and convenience are construed. To understand adolescent food choice, notions of health should be expanded to include constructs of body weight control and the natural content of food. The convergence of price and convenience items suggests that for adolescents such issues are strongly associated. Sensory items such as taste, texture and smell were shown to be less salient for adolescents than has previously been identified for adult populations. The findings suggest...
http://hdl.handle.net/2262/62430
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The Evaluation of Adaptive and User-Adaptive Systems: A Review
(2011)
WADE, VINCENT PATRICK; SHARP, MARY; LAWLESS, SEAMUS; MULWA, CATHERINE
The Evaluation of Adaptive and User-Adaptive Systems: A Review
(2011)
WADE, VINCENT PATRICK; SHARP, MARY; LAWLESS, SEAMUS; MULWA, CATHERINE
Abstract:
A current problem with the research of adaptive systems is the inconsistency of evaluation applied to the adaptive systems. However, evaluating an adaptive system is a difficult task due to the complexity of such systems. Evaluators need to ensure correct evaluation methods and measurement metrics are used. This paper reviews a variety of evaluation techniques applied in adaptive and user-adaptive systems. More specifically, it focuses on the user-centred evaluation of adaptive systems such as personalised recommender systems and adaptive information retrieval systems. The review tackles the question of ‘How have user-centred evaluations of adaptive and user-adaptive systems been conducted and how can these evaluation practices be improved?’ Based on the analysed results of the: (a) evaluation approaches, (b) user-centred evaluation techniques, and (c) evaluation metrics, we propose an evaluation framework for end-user experience in evaluating adaptive systems (EFEx).
http://hdl.handle.net/2262/62458
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An Evaluation Framework for End-User Experience in Adaptive Systems
(2011)
SHARP, MARY; WADE, VINCENT PATRICK; LAWLESS, SEAMUS; MULWA, CATHERINE
An Evaluation Framework for End-User Experience in Adaptive Systems
(2011)
SHARP, MARY; WADE, VINCENT PATRICK; LAWLESS, SEAMUS; MULWA, CATHERINE
Abstract:
The evaluation of adaptive and personalised systems is a difficult, complicated and very demanding endeavour due to the complex nature of these systems and the usability issues encountered. This demonstration introduces a web-based framework to support the evaluation of end-user experience in adaptive and personalised systems. This framework has been developed based upon advice from domain experts and a review of evaluation approaches, methodologies and techniques adopted by existing adaptive systems. The benefits of the framework include: i) the provision of an interactive reference and recommendation tool to encourage the evaluation of adaptive systems; ii) the collaborative nature of the framework facilitates the sharing of evaluation information among researchers from diverse communities; iii) the identification of pitfalls in the planning process as well as in data analysis; and iv) the translation of presented information into users language of choice.
http://hdl.handle.net/2262/62479
Marked
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User-centred Evaluations of Adaptive Systems
(2010)
SHARP, MARY; WADE, VINCENT PATRICK; LAWLESS, SEAMUS; MULWA, CATHERINE
User-centred Evaluations of Adaptive Systems
(2010)
SHARP, MARY; WADE, VINCENT PATRICK; LAWLESS, SEAMUS; MULWA, CATHERINE
Abstract:
Adaptive Hypermedia (AH) research is concerned with the dynamic composition and personalisation of hypermedia documents in order to provide more context sensitive retrieval and reuse of digital content. The evaluation of Adaptive Hypermedia Systems (AHS) is difficult due to the complexity of such systems [1]. Several Problems and pitfalls are encountered when evaluating these systems [2-6]. Very little research has been carried out to address this problem. This PhD work proposes a user-centred approach to the evaluation of the adaptive mechanism of AHS. The proposed approach will be validated using personalised systems developed by the Centre for Next Generation Localisation (CNGL). The framework developed by this research will help to standardise current approaches, offer hints regarding the identification of failures and misconceptions of the adaptive mechanism. It will be applicable to all adaptive systems with no limitations of domain or inference mechanism. A review of approach...
http://hdl.handle.net/2262/62478
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An Evaluation Framework for End-User Experience in Adaptive Systems
(2011)
SHARP, MARY; MULWA, CATHERINE; WADE, VINCENT PATRICK; LAWLESS, SEAMUS
An Evaluation Framework for End-User Experience in Adaptive Systems
(2011)
SHARP, MARY; MULWA, CATHERINE; WADE, VINCENT PATRICK; LAWLESS, SEAMUS
Abstract:
The evaluation of adaptive and personalised systems is a difficult, complicated and very demanding endeavour due to the complex nature of these systems and the usability issues encountered. This demonstration introduces a web-based framework to support the evaluation of end-user experience in adaptive and personalised systems. This framework has been developed based upon advice from domain experts and a review of evaluation approaches, methodologies and techniques adopted by existing adaptive systems. The benefits of the framework include: i) the provision of an interactive reference and recommendation tool to encourage the evaluation of adaptive systems; ii) the collaborative nature of the framework facilitates the sharing of evaluation information among researchers from diverse communities; iii) the identification of pitfalls in the planning process as well as in data analysis; and iv) the translation of presented information into users language of choice.
http://hdl.handle.net/2262/62480
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Further reading [ a selective bibliography of Irish Crime Writing 1829-2010 ]
(2011)
MAWE, SHANE
Further reading [ a selective bibliography of Irish Crime Writing 1829-2010 ]
(2011)
MAWE, SHANE
Abstract:
The following list does not pretend to determine the ‘best of’’ Irish crime writing. Instead, it offers a conspectus of Irish authors of crime fiction, writing in English and Irish, from the mid-nineteenth century to the present day, each represented by a single title. Although most titles are adult fiction, a sampling of crime writing for children and young adults is also included. As with other popular genres, crime fiction moves, sometimes mysteriously, in and out of print. Here, the publication details refer to the first edition but most of the following have been reprinted (often many times and under different imprints) and many are currently in print. For hard-to-find earlier works, we have given the URL for freely available online titles.
http://hdl.handle.net/2262/62477
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A wavelet-based Bayesian framework for 3D object segmentation in microscopy
(2012)
KOKARAM, ANIL CHRISTOPHER; PAN, KANGYU; RAMASWAMI, MANI; CORRIGAN, DAVID
A wavelet-based Bayesian framework for 3D object segmentation in microscopy
(2012)
KOKARAM, ANIL CHRISTOPHER; PAN, KANGYU; RAMASWAMI, MANI; CORRIGAN, DAVID
Abstract:
In confocal microscopy, target objects are labeled with fluorescent markers in the living specimen, and usually appear with irregular brightness in the observed images. Also, due to the existence of out-of-focus objects in the image, the segmentation of 3-D objects in the stack of image slices captured at different depth levels of the specimen is still heavily relied on manual analysis. In this paper, a novel Bayesian model is proposed for segmenting 3-D synaptic objects from given image stack. In order to solve the irregular brightness and out-offocus problems, the segmentation model employs a likelihood using the luminance-invariant 'wavelet features' of image objects in the dual-tree complex wavelet domain as well as a likelihood based on the vertical intensity profile of the image stack in 3-D. Furthermore, a smoothness 'frame' prior based on the a priori knowledge of the connections of the synapses is introduced to the model for enhancing the connectivity of...
http://hdl.handle.net/2262/62460
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Multilingual Adaptive Search for Digital Libraries
(2011)
WADE, VINCENT PATRICK; O'CONNOR, ALEXANDER; ZHOU, DONG; LAWLESS, SEAMUS; GHORAB, M...
Multilingual Adaptive Search for Digital Libraries
(2011)
WADE, VINCENT PATRICK; O'CONNOR, ALEXANDER; ZHOU, DONG; LAWLESS, SEAMUS; GHORAB, MOHAMMED RAMI ELHUSSEIN
Abstract:
We describe a framework for Adaptive Multilingual Information Retrieval (AMIR) which allows multilingual resource discovery and delivery using on-the-fly machine translation of documents and queries. Result documents are presented to the user in a contextualised manner. Challenges and affordances of both adaptive and multilingual IR, with a particular focus on digital libraries, are detailed. The framework components are motivated by a series of results from experiments on query logs and documents from The European Library. We conclude that factoring adaptivity and multilinguality aspects into the search process can enhance the user’s experience with online digital libraries.
http://hdl.handle.net/2262/62481
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A Proposal for the Evaluation of Adaptive Content Retrieval, Modification and Delivery
(2011)
WADE, VINCENT PATRICK; LAWLESS, SEAMUS; LEVACHER, KILLIAN
A Proposal for the Evaluation of Adaptive Content Retrieval, Modification and Delivery
(2011)
WADE, VINCENT PATRICK; LAWLESS, SEAMUS; LEVACHER, KILLIAN
Abstract:
A key advantage of Adaptive Hypermedia Systems (AHS) is their ability to re-sequence and reintegrate content to satisfy a particular user’s need, context or requirements. However, this requires large volumes of content, with appropriate granularities and suitable meta-data descriptions, representing a major impediment to the mainstream adoption of Adaptive Hypermedia. Open- corpus content is now widely available on the web, however, traditional information retrieval (IR) approaches are an inadequate means of incorporating these external content resources within AHS. This is due to the “one size fits all” content delivery paradigm offered by traditional IR. Slicing technology addresses these limitations by providing adaptive retrieval of open corpus resources, tailored to suit AHS specific content requirements. This is achieved through the on demand provision of tailored content called slices. This paper introduces slicing systems and details the objectives and challenges involved in...
http://hdl.handle.net/2262/62482
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The CULTURA Project: CULTivating Understanding and Research through Adaptivity
(2011)
LAWLESS, SEAMUS
The CULTURA Project: CULTivating Understanding and Research through Adaptivity
(2011)
LAWLESS, SEAMUS
Abstract:
CULTURA will deliver personalisation and community-aware adaptivity for Digital Humanities communities through an innovative environment which is tailored to the investigation, comprehension and enrichment of digital humanities collections. CULTURA seeks to stim- ulate and support the communities of interest which form around such collections.
http://hdl.handle.net/2262/62483
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A Web-based Framework for the Evaluation of End-User Experience in Adaptive and Personalised eLearning Systems
(2011)
SHARP, MARY; LAWLESS, SEAMUS; MULWA, CATHERINE; WADE, VINCENT PATRICK
A Web-based Framework for the Evaluation of End-User Experience in Adaptive and Personalised eLearning Systems
(2011)
SHARP, MARY; LAWLESS, SEAMUS; MULWA, CATHERINE; WADE, VINCENT PATRICK
Abstract:
The evaluation of interactive adaptive and personalised systems has long been acknowledged as a difficult, complicated and very demanding endeavour due to the complex nature of these systems. This paper describes a web-based framework for the evaluation of end-user experience in adaptive and personalised e-Learning systems. The benefits of the framework include: i) the provision of an interactive reference and recommendation tool to encourage the evaluation of systems that fulfil certain methodological requirements; ii) the collaborative nature of the framework facilitates the sharing of information among researchers from the information technology, adaptive hypermedia, information retrieval and e-Learning communities; iii) the identification of pitfalls in the evaluation planning process as well as in data analysis; and iv) the translation of presented information into users language of choice. This paper also presents a review of User-Centred Evaluation approaches, methodologies a...
http://hdl.handle.net/2262/62484
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Enhancing Access to Open Corpus Educational Content: Learning in the Wild
(2008)
HEDERMAN, LUCY MARY; WADE, VINCENT PATRICK; LAWLESS, SEAMUS
Enhancing Access to Open Corpus Educational Content: Learning in the Wild
(2008)
HEDERMAN, LUCY MARY; WADE, VINCENT PATRICK; LAWLESS, SEAMUS
Abstract:
The World Wide Web (WWW) provides access to a vast array of interconnected educational content on almost every subject imaginable. A great deal of this content is ideal for incorporation into personalised eLearning experiences. However the discovery, harvesting and incorporation of appropriate educational material have proven to be complex and arduous tasks. Traditional educational hypertext systems are based upon the generation of links and anchors between content objects [1]. However the dynamic incorporation of open corpus educational content in eLearning requires the generation of a relationship between educational concepts and the hypertext documents. One approach to create this overlay between concept and content is to use a Mindmap interface to allow learners to explore and associate hypertext content with knowledge maps of their own creation. This paper presents the Open Corpus Content Service (OCCS), a framework that uses the hypertext structure of the WWW to provide method...
http://hdl.handle.net/2262/62486
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A Framework for the Evaluation of Adaptive IR Systems through Implicit Recommendation
(2011)
SHARP, MARY; LAWLESS, SEAMUS; MULWA, CATHERINE; WADE, VINCENT PATRICK; GHORAB, MOHAMMED...
A Framework for the Evaluation of Adaptive IR Systems through Implicit Recommendation
(2011)
SHARP, MARY; LAWLESS, SEAMUS; MULWA, CATHERINE; WADE, VINCENT PATRICK; GHORAB, MOHAMMED RAMI ELHUSSEIN; O'DONNELL, EILEEN
Abstract:
Personalised Information Retrieval (PIR) has gained considerable attention in recent literature. In PIR different stages of the retrieval process are adapted to the user, such as adapting the user’s query or the results. Personalised recommender frameworks are endowed with intelligent mechanisms to search for products, goods and services that users are interested in. The objective of such tools is to evaluate and filter the huge amount of information available within a specific scope to assist users in their information access processes. This paper presents a web-based adaptive framework for evaluating personalised information retrieval systems. The framework uses implicit recommendation to guide users in deciding which evaluation techniques, metrics and criteria to use. A task-based experiment was conducted to test the functionality and performance of the framework. A Review of evaluation techniques for personalised IR systems was conducted and the results of the analysed survey ar...
http://hdl.handle.net/2262/62487
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Linking localisation and language resources
(2012)
LEWIS, DAVID; JONES, DOMINIC; LAWLESS, SEAMUS
Linking localisation and language resources
(2012)
LEWIS, DAVID; JONES, DOMINIC; LAWLESS, SEAMUS
Abstract:
Industrial localisation is changing from the periodic translation of large bodies of content to a long-tail of small, heterogeneous translations processed in an agile and demand-driven manner. Software localisation and crowd-source translation already practice continuous fine-grained distribution of translation work. This requires close integration and round-trip interoperabil- ity between content creation and localisation processes, while at the same time recording the provenance of translated content to maximise it reuse in future translation tasks, and, increasingly, in training Statistical Machine Translation (SMT) engines. This work adopts a Linked Data approach to integrating the content translation roundtrip process with the logging of process quality assur- ance provenance. This integration supports a pull-based interoperability model that supports continuous synchronising of content and process meta-data be- tween the generating organisation and any number of language servi...
http://hdl.handle.net/2262/62488
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Quantification of Subsurface Damage in a Brittle Insulating Ceramic by Three-Dimensional Focused Ion Beam Tomography
(2011)
O'KELLY, KEVIN
Quantification of Subsurface Damage in a Brittle Insulating Ceramic by Three-Dimensional Focused Ion Beam Tomography
(2011)
O'KELLY, KEVIN
Abstract:
In this study, we present a fully automated method to investigate and reconstruct the three-dimensional crack structure beneath an indent in a highly insulating material. This work concentrates on issues arising from a long automatic acquisition process, the insulating nature of the specimen, and the introduction of minimal damage to the original cracks resulting from indentation.
http://hdl.handle.net/2262/62459
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Self-assembled broadband plasmonic nanoparticle arrays for sensing applications
(2012)
SHVETS, IGOR; FLEISCHER, KARSTEN
Self-assembled broadband plasmonic nanoparticle arrays for sensing applications
(2012)
SHVETS, IGOR; FLEISCHER, KARSTEN
Abstract:
Highly ordered noble metal nanoparticle (NP) arrays are produced using a glancing angle deposition on stepped substrates. The versatility of the technique is demonstrated by depositing different metals, resulting in shifts of the resonance positions. The behaviour of the NP arrays grown is predicted by a dipolar model, and it is measured using reflectance anisotropy spectroscopy (RAS). Fine tuning of the resonances can be finally realised by selecting the deposition parameters. The combined application of both RAS and deposition at glancing angles provides a unique tool to grow NP arrays with the tunable plasmonic resonances in the entire visible range.
http://hdl.handle.net/2262/62535
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Using support vector machines with multiple indices of diffusion for automated classification of mild cognitive impairment.
(2012)
COLLINS, DANIEL RONAN; COUGHLAN, TARA LEAH; BOKDE, ARUN LAWRENCE WARREN; O'NEILL, ...
Using support vector machines with multiple indices of diffusion for automated classification of mild cognitive impairment.
(2012)
COLLINS, DANIEL RONAN; COUGHLAN, TARA LEAH; BOKDE, ARUN LAWRENCE WARREN; O'NEILL, DESMOND; BARTLEY, MAIREAD MARY
Abstract:
Few studies have looked at the potential of using diffusion tensor imaging (DTI) in conjunction with machine learning algorithms in order to automate the classification of healthy older subjects and subjects with mild cognitive impairment (MCI). Here we apply DTI to 40 healthy older subjects and 33 MCI subjects in order to derive values for multiple indices of diffusion within the white matter voxels of each subject. DTI measures were then used together with support vector machines (SVMs) to classify control and MCI subjects. Greater than 90% sensitivity and specificity was achieved using this method, demonstrating the potential of a joint DTI and SVM pipeline for fast, objective classification of healthy older and MCI subjects. Such tools may be useful for large scale drug trials in Alzheimer's disease where the early identification of subjects with MCI is critical.
http://hdl.handle.net/2262/62538
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Recent developments of functional magnetic resonance imaging research for drug development in Alzheimer's disease
(2011)
HAMPEL, HARALD; BOKDE, ARUN LAWRENCE WARREN
Recent developments of functional magnetic resonance imaging research for drug development in Alzheimer's disease
(2011)
HAMPEL, HARALD; BOKDE, ARUN LAWRENCE WARREN
Abstract:
The objective of this review is to evaluate recent advances in functional magnetic resonance imaging (fMRI) research in Alzheimer's disease for the development of therapeutic agents. The basic building block underpinning cognition is a brain network. The measured brain activity serves as an integrator of the various components, from genes to structural integrity, that impact the function of networks underpinning cognition. Specific networks can be interrogated using cognitive paradigms such as a learning task or a working memory task. In addition, recent advances in our understanding of neural networks allow one to investigate the function of a brain network by investigating the inherent coherency of the brain networks that can be measured during resting state. The coherent resting state networks allow testing in cognitively impaired patients that may not be possible with the use of cognitive paradigms. In particular the default mode network (DMN) includes the medial temporal l...
http://hdl.handle.net/2262/62537
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Acid Treatment effects on the stable isotopic signature of fossils
(2012)
NICHOLAS, CHRISTOPHER JOHN
Acid Treatment effects on the stable isotopic signature of fossils
(2012)
NICHOLAS, CHRISTOPHER JOHN
Abstract:
Prior to geochemical analyses, fossil bones and teeth are often extracted from any surrounding lithified sediments using chemical techniques such as immersion in acid. As stable isotope analysis becomes more commonplace in palaeoecological investigations, it is important to consider what effects these chemical preparation techniques may have on any subsequent isotopic data and to constrain these effects as quantitatively as possible. This study aims to elucidate these effects, as it is vital that variability in a data set should not be introduced as a result of protocols used during sample preparation; in addition, it defines the most effective and viable method of carbonate removal for processing bulk fossil samples without causing alteration of their stable isotopic signatures. Various strengths of two weak acids commonly used during palaeontological preparation were tested to evaluate their effects on the δ15N and δ13Corg isotopic signatures of the vertebrae of a large Eocene fos...
http://hdl.handle.net/2262/62534
Marked
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Mechanisms of aggregation inhibition by aspirin and nitrate-aspirin prodrugs in human platelets
(2012)
SANTOS-MARTINEZ, MARIA JOSE; RADOMSKI, MAREK
Mechanisms of aggregation inhibition by aspirin and nitrate-aspirin prodrugs in human platelets
(2012)
SANTOS-MARTINEZ, MARIA JOSE; RADOMSKI, MAREK
Abstract:
OBJECTIVES: Aspirin is the mainstay of anti-platelet therapy in the secondary prevention of cardiovascular disease. However, problems with aspirin safety and resistance demand clinical strategies based on multiple pharmacological approaches. Prodrugs of aspirin may offer beneficial effects in terms of gastro-intestinal safety and multiple pharmacological approaches. However, the pharmacological profile of aspirin prodrugs in human platelets has not been completed yet. We aimed to compare the effects of aspirin and prodrugs of aspirin (1-5) on human platelet aggregation stimulated by ADP and collagen and associated receptor expression (GPIIb/IIIa and P-selectin) in platelet-rich plasma (PRP) and washed platelets (WP). METHODS: As aspirin is released from prodrugs following esterase hydrolysis we studied the expression and activity of butyrylcholineterase (BuChE) and carboxyesterase (CE) in plasma and platelets. The mechanism of prodrug-induced platelet aggregation inhibition was expl...
http://hdl.handle.net/2262/62536
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Functional magnetic resonance imaging as a dynamic candidate biomarker for Alzheimer's disease.
(2011)
BOKDE, ARUN LAWRENCE WARREN; HAMPEL, HARALD
Functional magnetic resonance imaging as a dynamic candidate biomarker for Alzheimer's disease.
(2011)
BOKDE, ARUN LAWRENCE WARREN; HAMPEL, HARALD
Abstract:
During the last two decades, imaging of neural activation has become an invaluable tool for assessing the functional organization of the human brain in vivo. Due to its widespread application in neuroscience, functional neuroimaging has raised the interest of clinical researchers in its possible use as a diagnostic biomarker. A hallmark feature of many neurodegenerative diseases is their chronic non-linear dynamic and highly complex preclinical course. Neurodegenerative diseases unfold over years to decades through clinically silent and asymptomatic stages of early adaptive, compensatory to pathophysiological (i.e. actively neurodegenerative) and decompensatory mechanisms in the brain – phases that are increasingly being considered as critical for primary and secondary preventive and therapeutic measures. Emerging evidence supports the concept of a potentially fully reversible functional phase that may precede the onset of micro- and macrostructural and cognitive decline, a potenti...
http://hdl.handle.net/2262/62539
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